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Potassium in PDB 4ihl: Human 14-3-3 Isoform Zeta in Complex with A Diphoyphorylated C-Raf Peptide and Cotylenin A

Enzymatic activity of Human 14-3-3 Isoform Zeta in Complex with A Diphoyphorylated C-Raf Peptide and Cotylenin A

All present enzymatic activity of Human 14-3-3 Isoform Zeta in Complex with A Diphoyphorylated C-Raf Peptide and Cotylenin A:
2.7.11.1;

Protein crystallography data

The structure of Human 14-3-3 Isoform Zeta in Complex with A Diphoyphorylated C-Raf Peptide and Cotylenin A, PDB code: 4ihl was solved by M.Molzan, C.Ottmann, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 49.40 / 2.20
Space group P 21 21 21
Cell size a, b, c (Å), α, β, γ (°) 72.280, 103.400, 112.580, 90.00, 90.00, 90.00
R / Rfree (%) 20 / 24.3

Potassium Binding Sites:

The binding sites of Potassium atom in the Human 14-3-3 Isoform Zeta in Complex with A Diphoyphorylated C-Raf Peptide and Cotylenin A (pdb code 4ihl). This binding sites where shown within 5.0 Angstroms radius around Potassium atom.
In total 2 binding sites of Potassium where determined in the Human 14-3-3 Isoform Zeta in Complex with A Diphoyphorylated C-Raf Peptide and Cotylenin A, PDB code: 4ihl:
Jump to Potassium binding site number: 1; 2;

Potassium binding site 1 out of 2 in 4ihl

Go back to Potassium Binding Sites List in 4ihl
Potassium binding site 1 out of 2 in the Human 14-3-3 Isoform Zeta in Complex with A Diphoyphorylated C-Raf Peptide and Cotylenin A


Mono view


Stereo pair view

A full contact list of Potassium with other atoms in the K binding site number 1 of Human 14-3-3 Isoform Zeta in Complex with A Diphoyphorylated C-Raf Peptide and Cotylenin A within 5.0Å range:
probe atom residue distance (Å) B Occ
A:K301

b:76.2
occ:1.00
O P:HOH311 2.5 54.0 1.0
OD2 A:ASP124 3.2 36.1 1.0
CG A:ASP124 4.0 32.6 1.0
NZ A:LYS120 4.1 29.6 1.0
CB A:ASP124 4.2 32.2 1.0
CE2 A:TYR125 4.2 33.0 1.0
O A:HOH513 4.2 39.7 1.0
OH A:TYR128 4.3 30.5 1.0
CD A:LYS49 4.4 47.3 1.0
O P:HOH310 4.4 40.3 1.0
O A:HOH443 4.5 42.8 1.0
OAJ A:1F5302 4.6 42.6 1.0
CG A:MET121 4.6 46.0 1.0
CB A:LYS49 4.7 30.4 1.0
CG A:LYS49 4.7 34.5 1.0
OG A:SER45 4.7 36.6 1.0
CAK A:1F5302 4.7 32.3 1.0
OH A:TYR125 4.7 34.2 1.0
CZ A:TYR125 4.9 38.3 1.0
CE2 A:TYR128 5.0 28.2 1.0
CD2 A:TYR125 5.0 33.0 1.0

Potassium binding site 2 out of 2 in 4ihl

Go back to Potassium Binding Sites List in 4ihl
Potassium binding site 2 out of 2 in the Human 14-3-3 Isoform Zeta in Complex with A Diphoyphorylated C-Raf Peptide and Cotylenin A


Mono view


Stereo pair view

A full contact list of Potassium with other atoms in the K binding site number 2 of Human 14-3-3 Isoform Zeta in Complex with A Diphoyphorylated C-Raf Peptide and Cotylenin A within 5.0Å range:
probe atom residue distance (Å) B Occ
B:K301

b:70.0
occ:1.00
O P:HOH313 2.5 47.5 1.0
OD2 B:ASP124 3.1 41.5 1.0
CG B:ASP124 3.9 42.5 1.0
CB B:ASP124 4.1 35.5 1.0
OH B:TYR128 4.2 35.4 1.0
NZ B:LYS120 4.2 35.3 1.0
O P:HOH302 4.2 41.7 1.0
O B:HOH417 4.3 43.3 1.0
CE2 B:TYR125 4.3 38.8 1.0
CD B:LYS49 4.3 58.0 1.0
O B:HOH490 4.5 42.3 1.0
CAK B:1F5302 4.5 28.3 1.0
OG B:SER45 4.6 40.5 1.0
CB B:LYS49 4.7 35.8 1.0
CG B:LYS49 4.7 43.0 1.0
OG1 P:THR234 4.8 32.2 0.5
ND2 B:ASN173 4.8 29.6 1.0
OAJ B:1F5302 4.8 39.8 1.0
OH B:TYR125 4.9 39.3 1.0
CG B:MET121 4.9 51.3 1.0
OD1 B:ASP124 5.0 38.5 1.0
NZ B:LYS49 5.0 61.7 1.0

Reference:

M.Molzan, S.Kasper, L.Roglin, M.Skwarczynska, T.Sassa, T.Inoue, F.Breitenbuecher, J.Ohkanda, N.Kato, M.Schuler, C.Ottmann. Stabilization of Physical Raf/14-3-3 Interaction By Cotylenin A As Treatment Strategy For Ras Mutant Cancers. Acs Chem.Biol. V. 8 1869 2013.
ISSN: ISSN 1554-8929
PubMed: 23808890
DOI: 10.1021/CB4003464
Page generated: Sun Dec 13 23:31:30 2020

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