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Potassium in PDB 4i9w: Human Two Pore Domain K+ Channel Traak (K2P4.1) - Fab Complex Structure

Protein crystallography data

The structure of Human Two Pore Domain K+ Channel Traak (K2P4.1) - Fab Complex Structure, PDB code: 4i9w was solved by S.G.Brohawn, R.Mackinnon, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 48.60 / 2.75
Space group P 1 21 1
Cell size a, b, c (Å), α, β, γ (°) 80.887, 138.905, 97.461, 90.00, 94.87, 90.00
R / Rfree (%) 20.1 / 23.6

Other elements in 4i9w:

The structure of Human Two Pore Domain K+ Channel Traak (K2P4.1) - Fab Complex Structure also contains other interesting chemical elements:

Calcium (Ca) 2 atoms

Potassium Binding Sites:

The binding sites of Potassium atom in the Human Two Pore Domain K+ Channel Traak (K2P4.1) - Fab Complex Structure (pdb code 4i9w). This binding sites where shown within 5.0 Angstroms radius around Potassium atom.
In total 5 binding sites of Potassium where determined in the Human Two Pore Domain K+ Channel Traak (K2P4.1) - Fab Complex Structure, PDB code: 4i9w:
Jump to Potassium binding site number: 1; 2; 3; 4; 5;

Potassium binding site 1 out of 5 in 4i9w

Go back to Potassium Binding Sites List in 4i9w
Potassium binding site 1 out of 5 in the Human Two Pore Domain K+ Channel Traak (K2P4.1) - Fab Complex Structure


Mono view


Stereo pair view

A full contact list of Potassium with other atoms in the K binding site number 1 of Human Two Pore Domain K+ Channel Traak (K2P4.1) - Fab Complex Structure within 5.0Å range:
probe atom residue distance (Å) B Occ
A:K401

b:87.3
occ:1.00
 O B:THR238 2.7 84.0 1.0
O B:ILE130 2.7 85.1 1.0
O A:THR238 2.7 91.5 1.0
O A:THR129 2.8 87.2 1.0
O A:ILE130 2.8 86.6 1.0
O B:THR129 2.8 91.3 1.0
O B:VAL239 2.9 90.1 1.0
O A:VAL239 3.0 94.4 1.0
K B:K403 3.1 83.5 1.0
C B:ILE130 3.5 85.2 1.0
C A:ILE130 3.5 88.3 1.0
C B:VAL239 3.5 91.5 1.0
C A:VAL239 3.6 91.6 1.0
K A:K402 3.7 96.9 1.0
C B:THR238 3.8 85.0 1.0
C A:THR238 3.9 93.0 1.0
C A:THR129 3.9 85.5 1.0
C B:THR129 4.0 91.9 1.0
CA B:ILE130 4.0 89.4 1.0
CA B:VAL239 4.0 89.2 1.0
CA A:ILE130 4.0 87.2 1.0
CA A:VAL239 4.1 97.8 1.0
N B:GLY240 4.4 94.7 1.0
N B:VAL239 4.4 86.7 1.0
N A:GLY131 4.4 85.3 1.0
N A:ILE130 4.5 85.1 1.0
N B:GLY131 4.5 84.1 1.0
N A:VAL239 4.5 92.2 1.0
N A:GLY240 4.5 88.7 1.0
N B:ILE130 4.5 92.2 1.0
CA B:GLY240 4.7 93.9 1.0
CA A:GLY131 4.7 86.8 1.0
CA B:GLY131 4.8 84.2 1.0
CA A:GLY240 4.8 86.2 1.0
OG1 A:THR238 4.8 97.9 1.0
OG1 B:THR238 4.8 85.1 1.0
O B:GLY240 4.9 91.4 1.0
CA B:THR238 5.0 85.7 1.0
O A:GLY240 5.0 77.9 1.0

Potassium binding site 2 out of 5 in 4i9w

Go back to Potassium Binding Sites List in 4i9w
Potassium binding site 2 out of 5 in the Human Two Pore Domain K+ Channel Traak (K2P4.1) - Fab Complex Structure


Mono view


Stereo pair view

A full contact list of Potassium with other atoms in the K binding site number 2 of Human Two Pore Domain K+ Channel Traak (K2P4.1) - Fab Complex Structure within 5.0Å range:
probe atom residue distance (Å) B Occ
A:K402

b:96.9
occ:1.00
 OG1 A:THR238 2.4 97.9 1.0
OG1 B:THR238 2.5 85.1 1.0
OG1 A:THR129 2.6 84.2 1.0
OG1 B:THR129 2.8 89.2 1.0
O A:THR238 3.1 91.5 1.0
O A:THR129 3.1 87.2 1.0
O B:THR238 3.2 84.0 1.0
O B:THR129 3.2 91.3 1.0
CB A:THR238 3.4 98.0 1.0
CB A:THR129 3.5 86.4 1.0
CB B:THR238 3.5 86.7 1.0
CB B:THR129 3.6 90.5 1.0
K A:K401 3.7 87.3 1.0
C A:THR129 3.9 85.5 1.0
C A:THR238 3.9 93.0 1.0
C B:THR238 4.0 85.0 1.0
C B:THR129 4.0 91.9 1.0
CA A:THR238 4.4 94.1 1.0
CA A:THR129 4.4 84.8 1.0
CA B:THR238 4.4 85.7 1.0
CA B:THR129 4.5 92.2 1.0
CG2 A:THR238 4.5 99.4 1.0
CG2 B:THR238 4.6 89.5 1.0
CG2 A:THR129 4.6 85.4 1.0
O A:THR237 4.8 0.1 1.0
CG2 B:THR129 4.8 91.1 1.0
N A:ILE130 4.9 85.1 1.0
O B:THR237 4.9 91.8 1.0
O A:THR128 4.9 86.1 1.0
N B:ILE130 5.0 92.2 1.0
N A:VAL239 5.0 92.2 1.0

Potassium binding site 3 out of 5 in 4i9w

Go back to Potassium Binding Sites List in 4i9w
Potassium binding site 3 out of 5 in the Human Two Pore Domain K+ Channel Traak (K2P4.1) - Fab Complex Structure


Mono view


Stereo pair view

A full contact list of Potassium with other atoms in the K binding site number 3 of Human Two Pore Domain K+ Channel Traak (K2P4.1) - Fab Complex Structure within 5.0Å range:
probe atom residue distance (Å) B Occ
B:K401

b:0.8
occ:1.00
 O B:GLY96 4.5 87.1 1.0

Potassium binding site 4 out of 5 in 4i9w

Go back to Potassium Binding Sites List in 4i9w
Potassium binding site 4 out of 5 in the Human Two Pore Domain K+ Channel Traak (K2P4.1) - Fab Complex Structure


Mono view


Stereo pair view

A full contact list of Potassium with other atoms in the K binding site number 4 of Human Two Pore Domain K+ Channel Traak (K2P4.1) - Fab Complex Structure within 5.0Å range:
probe atom residue distance (Å) B Occ
B:K402

b:81.2
occ:1.00
 O A:PHE241 2.5 85.3 1.0
O B:PHE241 2.5 93.4 1.0
O B:TYR132 2.5 79.8 1.0
O A:TYR132 2.7 84.5 1.0
O A:GLY240 3.0 77.9 1.0
O A:GLY131 3.0 90.3 1.0
O B:GLY131 3.1 76.2 1.0
O B:GLY240 3.1 91.4 1.0
K B:K403 3.4 83.5 1.0
C A:PHE241 3.4 86.4 1.0
C B:TYR132 3.4 86.0 1.0
C B:PHE241 3.5 94.3 1.0
C A:TYR132 3.5 85.0 1.0
CA A:PHE241 4.0 85.1 1.0
C A:GLY240 4.1 82.2 1.0
CA B:PHE241 4.1 90.1 1.0
CA B:TYR132 4.1 86.1 1.0
C A:GLY131 4.2 88.2 1.0
C B:GLY131 4.2 81.7 1.0
CA A:TYR132 4.2 84.8 1.0
C B:GLY240 4.2 90.8 1.0
N B:GLY133 4.3 91.2 1.0
N A:GLY133 4.4 85.2 1.0
N A:GLY242 4.4 86.8 1.0
N B:GLY242 4.5 98.0 1.0
CA B:GLY133 4.5 91.8 1.0
CA A:GLY133 4.5 83.5 1.0
N A:PHE241 4.6 81.3 1.0
N B:TYR132 4.6 84.5 1.0
N A:TYR132 4.7 85.4 1.0
N B:PHE241 4.7 89.3 1.0
CA B:GLY242 4.7 98.2 1.0
CA A:GLY242 4.8 88.4 1.0

Potassium binding site 5 out of 5 in 4i9w

Go back to Potassium Binding Sites List in 4i9w
Potassium binding site 5 out of 5 in the Human Two Pore Domain K+ Channel Traak (K2P4.1) - Fab Complex Structure


Mono view


Stereo pair view

A full contact list of Potassium with other atoms in the K binding site number 5 of Human Two Pore Domain K+ Channel Traak (K2P4.1) - Fab Complex Structure within 5.0Å range:
probe atom residue distance (Å) B Occ
B:K403

b:83.5
occ:1.00
 O B:GLY240 2.6 91.4 1.0
O A:GLY240 2.7 77.9 1.0
O B:GLY131 2.7 76.2 1.0
O A:VAL239 2.8 94.4 1.0
O A:GLY131 2.8 90.3 1.0
O B:ILE130 2.9 85.1 1.0
O B:VAL239 2.9 90.1 1.0
O A:ILE130 3.0 86.6 1.0
K A:K401 3.1 87.3 1.0
K B:K402 3.4 81.2 1.0
C B:GLY131 3.4 81.7 1.0
C B:GLY240 3.4 90.8 1.0
C A:GLY240 3.5 82.2 1.0
C A:GLY131 3.6 88.2 1.0
CA B:GLY131 3.9 84.2 1.0
C A:VAL239 3.9 91.6 1.0
CA B:GLY240 3.9 93.9 1.0
C B:ILE130 3.9 85.2 1.0
C B:VAL239 4.0 91.5 1.0
CA A:GLY240 4.0 86.2 1.0
CA A:GLY131 4.0 86.8 1.0
C A:ILE130 4.1 88.3 1.0
N B:TYR132 4.3 84.5 1.0
N B:GLY131 4.4 84.1 1.0
N A:GLY240 4.4 88.7 1.0
N B:GLY240 4.4 94.7 1.0
N B:PHE241 4.5 89.3 1.0
N A:PHE241 4.5 81.3 1.0
N A:GLY131 4.5 85.3 1.0
N A:TYR132 4.5 85.4 1.0
CA B:TYR132 4.7 86.1 1.0
O B:PHE241 4.8 93.4 1.0
CA B:PHE241 4.8 90.1 1.0
CA A:PHE241 4.8 85.1 1.0
O B:TYR132 4.8 79.8 1.0
CA A:TYR132 4.9 84.8 1.0
O A:PHE241 5.0 85.3 1.0
C B:TYR132 5.0 86.0 1.0

Reference:

S.G.Brohawn, E.B.Campbell, R.Mackinnon. Domain-Swapped Chain Connectivity and Gated Membrane Access in A Fab-Mediated Crystal of the Human Traak K+ Channel. Proc.Natl.Acad.Sci.Usa V. 110 2129 2013.
ISSN: ISSN 0027-8424
PubMed: 23341632
DOI: 10.1073/PNAS.1218950110
Page generated: Sun Dec 13 23:31:23 2020

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