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Potassium in PDB 4hxx: Pyridinylpyrimidines Selectively Inhibit Human Methionine Aminopeptidase-1

Enzymatic activity of Pyridinylpyrimidines Selectively Inhibit Human Methionine Aminopeptidase-1

All present enzymatic activity of Pyridinylpyrimidines Selectively Inhibit Human Methionine Aminopeptidase-1:
3.4.11.18;

Protein crystallography data

The structure of Pyridinylpyrimidines Selectively Inhibit Human Methionine Aminopeptidase-1, PDB code: 4hxx was solved by S.B.Gabelli, F.Zhang, J.Liu, L.M.Amzel, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 25.33 / 2.09
Space group P 1 21 1
Cell size a, b, c (Å), α, β, γ (°) 47.500, 77.403, 48.068, 90.00, 90.92, 90.00
R / Rfree (%) 19 / 25.8

Other elements in 4hxx:

The structure of Pyridinylpyrimidines Selectively Inhibit Human Methionine Aminopeptidase-1 also contains other interesting chemical elements:

Cobalt (Co) 3 atoms
Chlorine (Cl) 2 atoms

Potassium Binding Sites:

The binding sites of Potassium atom in the Pyridinylpyrimidines Selectively Inhibit Human Methionine Aminopeptidase-1 (pdb code 4hxx). This binding sites where shown within 5.0 Angstroms radius around Potassium atom.
In total only one binding site of Potassium was determined in the Pyridinylpyrimidines Selectively Inhibit Human Methionine Aminopeptidase-1, PDB code: 4hxx:

Potassium binding site 1 out of 1 in 4hxx

Go back to Potassium Binding Sites List in 4hxx
Potassium binding site 1 out of 1 in the Pyridinylpyrimidines Selectively Inhibit Human Methionine Aminopeptidase-1


Mono view


Stereo pair view

A full contact list of Potassium with other atoms in the K binding site number 1 of Pyridinylpyrimidines Selectively Inhibit Human Methionine Aminopeptidase-1 within 5.0Å range:
probe atom residue distance (Å) B Occ
A:K404

b:35.6
occ:1.00
 O A:VAL209 2.7 31.6 1.0
O A:SER363 2.7 34.3 1.0
O A:HOH508 2.8 30.5 1.0
O A:ASN207 2.9 33.8 1.0
O A:SER205 3.0 29.0 1.0
N A:ASN207 3.5 33.0 1.0
C A:SER205 3.6 28.5 1.0
C A:ASN207 3.7 32.7 1.0
C A:VAL206 3.7 31.6 1.0
C A:SER363 3.8 33.1 1.0
C A:VAL209 3.8 31.5 1.0
O A:VAL206 4.0 31.1 1.0
CA A:ASN207 4.0 33.0 1.0
N A:VAL206 4.1 30.2 1.0
CB A:SER205 4.2 27.4 1.0
CA A:VAL206 4.2 31.3 1.0
N A:VAL209 4.3 31.9 1.0
N A:SER363 4.4 34.9 1.0
CA A:SER363 4.4 33.4 1.0
CA A:VAL209 4.5 31.5 1.0
CB A:SER363 4.5 32.7 1.0
CA A:SER205 4.5 28.8 1.0
O A:HOH514 4.6 36.4 1.0
CG1 A:ILE225 4.6 33.0 1.0
N A:GLU208 4.7 32.6 1.0
CD1 A:ILE225 4.7 32.1 1.0
N A:ALA364 4.7 32.3 1.0
CA A:ALA364 4.8 31.4 1.0
CB A:VAL209 4.8 31.7 1.0
N A:ILE210 4.8 32.5 1.0
O A:ILE225 4.9 33.8 1.0
C A:GLU208 4.9 32.1 1.0
O A:HOH552 4.9 35.9 1.0

Reference:

P.Zhang, X.Yang, F.Zhang, S.B.Gabelli, R.Wang, Y.Zhang, S.Bhat, X.Chen, M.Furlani, L.M.Amzel, J.O.Liu, D.Ma. Pyridinylpyrimidines Selectively Inhibit Human Methionine Aminopeptidase-1. Bioorg.Med.Chem. V. 21 2600 2013.
ISSN: ISSN 0968-0896
PubMed: 23507151
DOI: 10.1016/J.BMC.2013.02.023
Page generated: Mon Aug 12 10:56:08 2024

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