Potassium in PDB 4h37: Crystal Structure of A Voltage-Gated K+ Channel Pore Domain in A Closed State in Lipid Membranes

The structure of Crystal Structure of A Voltage-Gated K+ Channel Pore Domain in A Closed State in Lipid Membranes, PDB code: 4h37 was solved by J.S.Santos, G.A.Asmar-Rovira, G.W.Han, W.Liu, R.Syeda, V.Cherezov, K.A.Baker, R.C.Stevens, M.Montal, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	32.60 / 3.35
Space group	P 21 21 2
Cell size a, b, c (Å), α, β, γ (°)	56.100, 80.670, 55.522, 90.00, 90.00, 90.00
R / Rfree (%)	31.4 / 34.1

The binding sites of Potassium atom in the Crystal Structure of A Voltage-Gated K+ Channel Pore Domain in A Closed State in Lipid Membranes (pdb code 4h37). This binding sites where shown within 5.0 Angstroms radius around Potassium atom.
In total 4 binding sites of Potassium where determined in the Crystal Structure of A Voltage-Gated K+ Channel Pore Domain in A Closed State in Lipid Membranes, PDB code: 4h37:
Jump to Potassium binding site number: 1; 2; 3; 4;

Potassium binding site 1 out of 4 in the Crystal Structure of A Voltage-Gated K+ Channel Pore Domain in A Closed State in Lipid Membranes


Mono view


Stereo pair view

A full contact list of Potassium with other atoms in the K binding site number 1 of Crystal Structure of A Voltage-Gated K+ Channel Pore Domain in A Closed State in Lipid Membranes within 5.0Å range: probe atom residue distance (Å) B Occ A:K201 b:0.4 occ:0.50 O A:GLY59 2.5 1.0 1.0 O B:GLY59 2.5 0.3 1.0 K A:K202 3.1 0.6 0.5 O A:TYR60 3.1 0.3 1.0 O B:TYR60 3.3 0.8 1.0 C A:TYR60 3.5 0.4 1.0 C A:GLY59 3.6 0.1 1.0 C B:GLY59 3.6 0.5 1.0 C B:TYR60 3.7 0.0 1.0 CA A:TYR60 3.8 0.8 1.0 CA B:TYR60 3.9 0.6 1.0 N A:TYR60 4.2 0.2 1.0 N B:TYR60 4.2 0.3 1.0 N A:GLY61 4.4 1.0 1.0 N B:GLY61 4.5 0.7 1.0 O B:VAL58 4.8 0.6 1.0 CA A:GLY59 4.8 0.7 1.0 CA B:GLY59 4.8 0.7 1.0 O A:VAL58 4.8 0.3 1.0 CA A:GLY61 4.9 0.9 1.0

Potassium binding site 2 out of 4 in the Crystal Structure of A Voltage-Gated K+ Channel Pore Domain in A Closed State in Lipid Membranes


Mono view


Stereo pair view

A full contact list of Potassium with other atoms in the K binding site number 2 of Crystal Structure of A Voltage-Gated K+ Channel Pore Domain in A Closed State in Lipid Membranes within 5.0Å range: probe atom residue distance (Å) B Occ A:K202 b:0.6 occ:0.50 O B:VAL58 2.4 0.6 1.0 O A:VAL58 2.5 0.3 1.0 O A:GLY59 2.6 1.0 1.0 O B:GLY59 2.7 0.3 1.0 K A:K203 3.0 0.1 0.5 K A:K201 3.1 0.4 0.5 C A:GLY59 3.6 0.1 1.0 C B:VAL58 3.6 0.7 1.0 C A:VAL58 3.6 0.5 1.0 C B:GLY59 3.7 0.5 1.0 CA A:GLY59 4.0 0.7 1.0 CA B:GLY59 4.0 0.7 1.0 N A:GLY59 4.2 0.6 1.0 N B:GLY59 4.2 0.7 1.0 N A:TYR60 4.7 0.2 1.0 CA B:VAL58 4.8 0.1 1.0 N B:TYR60 4.8 0.3 1.0 CA A:VAL58 4.8 0.9 1.0

Potassium binding site 3 out of 4 in the Crystal Structure of A Voltage-Gated K+ Channel Pore Domain in A Closed State in Lipid Membranes


Mono view


Stereo pair view

A full contact list of Potassium with other atoms in the K binding site number 3 of Crystal Structure of A Voltage-Gated K+ Channel Pore Domain in A Closed State in Lipid Membranes within 5.0Å range: probe atom residue distance (Å) B Occ A:K203 b:0.1 occ:0.50 O A:VAL58 2.8 0.3 1.0 O B:VAL58 2.8 0.6 1.0 O B:THR57 2.9 0.4 1.0 K A:K202 3.0 0.6 0.5 O A:THR57 3.0 0.6 1.0 C A:VAL58 3.6 0.5 1.0 C B:VAL58 3.6 0.7 1.0 C B:THR57 3.9 0.0 1.0 C A:THR57 3.9 0.9 1.0 CA B:VAL58 3.9 0.1 1.0 CA A:VAL58 4.0 0.9 1.0 K A:K204 4.3 0.2 0.5 N B:VAL58 4.3 0.0 1.0 N A:VAL58 4.4 0.6 1.0 N A:GLY59 4.6 0.6 1.0 N B:GLY59 4.7 0.7 1.0

Potassium binding site 4 out of 4 in the Crystal Structure of A Voltage-Gated K+ Channel Pore Domain in A Closed State in Lipid Membranes


Mono view


Stereo pair view

A full contact list of Potassium with other atoms in the K binding site number 4 of Crystal Structure of A Voltage-Gated K+ Channel Pore Domain in A Closed State in Lipid Membranes within 5.0Å range: probe atom residue distance (Å) B Occ A:K204 b:0.2 occ:0.50 OG1 B:THR57 3.3 0.8 1.0 OG1 A:THR57 3.3 0.7 1.0 O A:THR57 3.4 0.6 1.0 O B:THR57 3.4 0.4 1.0 CB A:THR57 4.0 0.6 1.0 CB B:THR57 4.0 0.8 1.0 K A:K203 4.3 0.1 0.5 C A:THR57 4.4 0.9 1.0 C B:THR57 4.5 0.0 1.0 CA A:THR57 4.9 0.4 1.0 CA B:THR57 4.9 0.2 1.0

J.S.Santos, G.A.Asmar-Rovira, G.W.Han, W.Liu, R.Syeda, V.Cherezov, K.A.Baker, R.C.Stevens, M.Montal. Crystal Structure of A Voltage-Gated K+ Channel Pore Module in A Closed State in Lipid Membranes. J.Biol.Chem. V. 287 43063 2012.
ISSN: ISSN 0021-9258
PubMed: 23095758
DOI: 10.1074/JBC.M112.415091