Potassium in PDB 4fo4: Inosine 5'-Monophosphate Dehydrogenase From Vibrio Cholerae, Deletion Mutant, Complexed with Imp and Mycophenolic Acid

All present enzymatic activity of Inosine 5'-Monophosphate Dehydrogenase From Vibrio Cholerae, Deletion Mutant, Complexed with Imp and Mycophenolic Acid:
1.1.1.205;

The structure of Inosine 5'-Monophosphate Dehydrogenase From Vibrio Cholerae, Deletion Mutant, Complexed with Imp and Mycophenolic Acid, PDB code: 4fo4 was solved by J.Osipiuk, N.Maltseva, M.Makowska-Grzyska, M.Gu, W.F.Anderson, A.Joachimiak, Center For Structural Genomics Of Infectious Diseases(Csgid), with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	35.60 / 2.03
Space group	P 4 21 2
Cell size a, b, c (Å), α, β, γ (°)	120.909, 120.909, 94.871, 90.00, 90.00, 90.00
R / Rfree (%)	16.5 / 21.3

The binding sites of Potassium atom in the Inosine 5'-Monophosphate Dehydrogenase From Vibrio Cholerae, Deletion Mutant, Complexed with Imp and Mycophenolic Acid (pdb code 4fo4). This binding sites where shown within 5.0 Angstroms radius around Potassium atom.
In total 2 binding sites of Potassium where determined in the Inosine 5'-Monophosphate Dehydrogenase From Vibrio Cholerae, Deletion Mutant, Complexed with Imp and Mycophenolic Acid, PDB code: 4fo4:
Jump to Potassium binding site number: 1; 2;

Potassium binding site 1 out of 2 in the Inosine 5'-Monophosphate Dehydrogenase From Vibrio Cholerae, Deletion Mutant, Complexed with Imp and Mycophenolic Acid


Mono view


Stereo pair view

A full contact list of Potassium with other atoms in the K binding site number 1 of Inosine 5'-Monophosphate Dehydrogenase From Vibrio Cholerae, Deletion Mutant, Complexed with Imp and Mycophenolic Acid within 5.0Å range: probe atom residue distance (Å) B Occ A:K503 b:41.0 occ:0.50 O A:GLY304 2.8 22.5 1.0 O A:CYS307 2.9 26.9 1.0 O A:GLY302 2.9 25.4 1.0 O A:HOH660 3.2 27.4 1.0 C A:CYS307 3.8 22.7 1.0 CB A:CYS307 3.8 27.9 1.0 C A:GLY304 3.9 24.4 1.0 C A:PRO303 3.9 23.4 1.0 O A:PRO303 4.0 22.1 1.0 C A:GLY302 4.0 24.7 1.0 N A:GLY304 4.1 23.9 1.0 CA A:CYS307 4.1 26.1 1.0 N A:CYS307 4.3 26.1 1.0 CA A:PRO303 4.3 22.5 1.0 SG A:CYS307 4.4 34.8 1.0 CA A:GLY304 4.5 24.4 1.0 N A:PRO303 4.7 23.6 1.0 O A:SER305 4.7 23.3 1.0 N A:THR308 4.9 23.3 1.0 N A:SER305 4.9 23.4 1.0 C A:SER305 5.0 25.3 1.0

Potassium binding site 2 out of 2 in the Inosine 5'-Monophosphate Dehydrogenase From Vibrio Cholerae, Deletion Mutant, Complexed with Imp and Mycophenolic Acid


Mono view


Stereo pair view

A full contact list of Potassium with other atoms in the K binding site number 2 of Inosine 5'-Monophosphate Dehydrogenase From Vibrio Cholerae, Deletion Mutant, Complexed with Imp and Mycophenolic Acid within 5.0Å range: probe atom residue distance (Å) B Occ B:K503 b:61.8 occ:1.00 O B:CYS307 2.9 26.0 1.0 O B:GLY304 2.9 28.3 1.0 O B:GLY302 2.9 29.8 1.0 O B:HOH642 3.0 31.6 1.0 C B:CYS307 3.8 27.5 1.0 CB B:CYS307 3.8 32.9 1.0 C B:PRO303 3.9 27.1 1.0 C B:GLY304 3.9 28.7 1.0 C B:GLY302 4.0 28.4 1.0 N B:GLY304 4.0 27.5 1.0 O B:PRO303 4.1 27.5 1.0 SG B:CYS307 4.2 40.0 1.0 CA B:CYS307 4.2 30.9 1.0 N B:CYS307 4.3 29.3 1.0 CA B:PRO303 4.3 26.5 1.0 CA B:GLY304 4.5 28.7 1.0 N B:PRO303 4.7 25.6 1.0 N B:THR308 4.8 26.6 1.0 CA B:GLY302 4.9 30.0 1.0 O B:SER305 4.9 28.1 1.0 N B:SER305 5.0 28.5 1.0

J.Osipiuk, N.Maltseva, M.Makowska-Grzyska, M.Gu, W.F.Anderson, A.Joachimiak. Inosine 5'-Monophosphate Dehydrogenase From Vibrio Cholerae, Deletion Mutant, Complexed with Imp and Mycophenolic Acid. To Be Published.