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Potassium in PDB 4evy: Crystal Structure of Aminoglycoside Antibiotic 6'-N-Acetyltransferase Aac(6')-Ig From Acinetobacter Haemolyticus in Complex with Tobramycin

Enzymatic activity of Crystal Structure of Aminoglycoside Antibiotic 6'-N-Acetyltransferase Aac(6')-Ig From Acinetobacter Haemolyticus in Complex with Tobramycin

All present enzymatic activity of Crystal Structure of Aminoglycoside Antibiotic 6'-N-Acetyltransferase Aac(6')-Ig From Acinetobacter Haemolyticus in Complex with Tobramycin:
2.3.1.82;

Protein crystallography data

The structure of Crystal Structure of Aminoglycoside Antibiotic 6'-N-Acetyltransferase Aac(6')-Ig From Acinetobacter Haemolyticus in Complex with Tobramycin, PDB code: 4evy was solved by P.J.Stogios, E.Evdokimova, G.Minasov, V.Yim, P.Courvalin, A.Savchenko, W.F.Anderson, Center For Structural Genomics Of Infectious Diseases(Csgid), with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 28.97 / 1.77
Space group P 1
Cell size a, b, c (Å), α, β, γ (°) 39.723, 43.789, 46.282, 83.65, 87.49, 68.41
R / Rfree (%) 16.7 / 21.3

Other elements in 4evy:

The structure of Crystal Structure of Aminoglycoside Antibiotic 6'-N-Acetyltransferase Aac(6')-Ig From Acinetobacter Haemolyticus in Complex with Tobramycin also contains other interesting chemical elements:

Chlorine (Cl) 3 atoms

Potassium Binding Sites:

The binding sites of Potassium atom in the Crystal Structure of Aminoglycoside Antibiotic 6'-N-Acetyltransferase Aac(6')-Ig From Acinetobacter Haemolyticus in Complex with Tobramycin (pdb code 4evy). This binding sites where shown within 5.0 Angstroms radius around Potassium atom.
In total 2 binding sites of Potassium where determined in the Crystal Structure of Aminoglycoside Antibiotic 6'-N-Acetyltransferase Aac(6')-Ig From Acinetobacter Haemolyticus in Complex with Tobramycin, PDB code: 4evy:
Jump to Potassium binding site number: 1; 2;

Potassium binding site 1 out of 2 in 4evy

Go back to Potassium Binding Sites List in 4evy
Potassium binding site 1 out of 2 in the Crystal Structure of Aminoglycoside Antibiotic 6'-N-Acetyltransferase Aac(6')-Ig From Acinetobacter Haemolyticus in Complex with Tobramycin


Mono view


Stereo pair view

A full contact list of Potassium with other atoms in the K binding site number 1 of Crystal Structure of Aminoglycoside Antibiotic 6'-N-Acetyltransferase Aac(6')-Ig From Acinetobacter Haemolyticus in Complex with Tobramycin within 5.0Å range:
probe atom residue distance (Å) B Occ
A:K202

b:29.0
occ:0.75
 O A:LEU36 2.7 21.0 1.0
OE1 A:GLN44 2.8 31.9 1.0
O A:GLU39 2.8 24.2 1.0
O A:ALA42 3.1 25.9 1.0
O A:LEU37 3.6 27.4 1.0
CD A:GLN44 3.7 27.7 1.0
C A:GLU39 3.8 25.8 1.0
C A:LEU36 3.9 24.1 1.0
C A:LEU37 3.9 22.6 1.0
C A:ALA42 3.9 20.7 1.0
NE2 A:GLN44 4.0 21.3 1.0
CA A:LEU37 4.0 21.8 1.0
N A:GLU39 4.1 23.1 1.0
CB A:ALA42 4.2 23.1 1.0
O A:HOH309 4.3 26.5 1.0
N A:LEU37 4.4 19.2 1.0
CA A:GLU39 4.5 22.0 1.0
O A:HOH326 4.5 26.6 1.0
CA A:ALA42 4.5 21.1 1.0
O A:HOH305 4.6 27.7 1.0
N A:ALA42 4.6 18.8 1.0
N A:ALA38 4.7 26.4 1.0
N A:LYS40 4.7 26.1 1.0
CA A:LYS40 4.8 28.8 1.0
N A:LEU43 4.8 20.4 1.0
CB A:GLU39 4.9 26.0 1.0
CA A:LEU43 5.0 20.4 1.0

Potassium binding site 2 out of 2 in 4evy

Go back to Potassium Binding Sites List in 4evy
Potassium binding site 2 out of 2 in the Crystal Structure of Aminoglycoside Antibiotic 6'-N-Acetyltransferase Aac(6')-Ig From Acinetobacter Haemolyticus in Complex with Tobramycin


Mono view


Stereo pair view

A full contact list of Potassium with other atoms in the K binding site number 2 of Crystal Structure of Aminoglycoside Antibiotic 6'-N-Acetyltransferase Aac(6')-Ig From Acinetobacter Haemolyticus in Complex with Tobramycin within 5.0Å range:
probe atom residue distance (Å) B Occ
B:K202

b:32.5
occ:1.00
 O B:ALA42 2.7 23.3 1.0
O B:GLU39 2.8 27.6 1.0
O B:HOH365 2.8 42.8 1.0
O B:LEU36 3.2 31.5 1.0
OE1 B:GLN44 3.5 47.1 1.0
O B:LEU37 3.5 47.8 1.0
C B:GLU39 3.8 27.1 1.0
C B:ALA42 3.9 21.6 1.0
O B:HOH344 4.0 30.5 1.0
C B:LEU37 4.0 32.8 1.0
O B:HOH338 4.0 35.3 1.0
CD B:GLN44 4.2 41.5 1.0
N B:GLU39 4.2 28.8 1.0
NE2 B:GLN44 4.3 29.9 1.0
CA B:LEU37 4.3 29.8 1.0
C B:LEU36 4.4 39.7 1.0
O B:HOH309 4.5 27.7 1.0
CB B:ALA42 4.6 24.5 1.0
CA B:GLU39 4.6 32.4 1.0
CA B:ALA42 4.6 20.1 1.0
N B:ALA42 4.7 23.2 1.0
N B:LYS40 4.7 33.1 1.0
CA B:LYS40 4.7 33.6 1.0
C B:ALA38 4.7 34.2 1.0
N B:ALA38 4.8 30.7 1.0
N B:LEU37 4.9 31.3 1.0
N B:LEU43 4.9 23.4 1.0
C B:LYS40 4.9 28.9 1.0
O B:LYS40 5.0 34.5 1.0

Reference:

P.J.Stogios, M.L.Kuhn, E.Evdokimova, M.Law, P.Courvalin, A.Savchenko. Structural and Biochemical Characterization of Acinetobacter Spp. Aminoglycoside Acetyltransferases Highlights Functional and Evolutionary Variation Among Antibiotic Resistance Enzymes. Acs Infect Dis. V. 3 132 2017.
ISSN: ESSN 2373-8227
PubMed: 27785912
DOI: 10.1021/ACSINFECDIS.6B00058
Page generated: Sat Aug 9 06:46:00 2025

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