Potassium in PDB 4den: Structural Insightsinto Potent, Specific Anti-Hiv Property of Actinohivin; Crystal Structure of Actinohivin in Complex with Alpha(1-2) Mannobiose Moiety of High-Mannose Type Glycan of GP120

The structure of Structural Insightsinto Potent, Specific Anti-Hiv Property of Actinohivin; Crystal Structure of Actinohivin in Complex with Alpha(1-2) Mannobiose Moiety of High-Mannose Type Glycan of GP120, PDB code: 4den was solved by M.M.Hoque, K.Suzuki, M.Tsunoda, J.Jiang, F.Zhang, A.Takahashi, O.Naomi, X.Zhang, T.Sekiguchi, H.Tanaka, S.Omura, A.Takenaka, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	39.75 / 1.60
Space group	P 21 3
Cell size a, b, c (Å), α, β, γ (°)	56.217, 56.217, 56.217, 90.00, 90.00, 90.00
R / Rfree (%)	14.5 / 20.2

The binding sites of Potassium atom in the Structural Insightsinto Potent, Specific Anti-Hiv Property of Actinohivin; Crystal Structure of Actinohivin in Complex with Alpha(1-2) Mannobiose Moiety of High-Mannose Type Glycan of GP120 (pdb code 4den). This binding sites where shown within 5.0 Angstroms radius around Potassium atom.
In total 3 binding sites of Potassium where determined in the Structural Insightsinto Potent, Specific Anti-Hiv Property of Actinohivin; Crystal Structure of Actinohivin in Complex with Alpha(1-2) Mannobiose Moiety of High-Mannose Type Glycan of GP120, PDB code: 4den:
Jump to Potassium binding site number: 1; 2; 3;

Potassium binding site 1 out of 3 in the Structural Insightsinto Potent, Specific Anti-Hiv Property of Actinohivin; Crystal Structure of Actinohivin in Complex with Alpha(1-2) Mannobiose Moiety of High-Mannose Type Glycan of GP120


Mono view


Stereo pair view

A full contact list of Potassium with other atoms in the K binding site number 1 of Structural Insightsinto Potent, Specific Anti-Hiv Property of Actinohivin; Crystal Structure of Actinohivin in Complex with Alpha(1-2) Mannobiose Moiety of High-Mannose Type Glycan of GP120 within 5.0Å range: probe atom residue distance (Å) B Occ A:K204 b:14.0 occ:0.33 O A:ASN150 2.6 11.4 0.3 O9 A:2M4203 2.8 9.3 0.3 C A:ASN150 3.8 11.2 0.3 C10 A:2M4203 4.0 9.7 0.3 CB A:ASN150 4.3 11.8 0.3 CA A:ASN150 4.6 12.1 0.3 N A:GLY152 4.7 9.5 0.3 OD1 A:ASN150 4.7 12.6 0.3 N A:GLY151 4.8 11.9 0.3 CG A:ASN150 4.8 13.8 0.3 CA A:GLY151 4.8 10.3 0.3 C A:GLY151 4.8 9.1 0.3 O8 A:2M4203 4.8 12.2 0.3 C5 A:2M4203 4.9 7.0 0.3

Potassium binding site 2 out of 3 in the Structural Insightsinto Potent, Specific Anti-Hiv Property of Actinohivin; Crystal Structure of Actinohivin in Complex with Alpha(1-2) Mannobiose Moiety of High-Mannose Type Glycan of GP120


Mono view


Stereo pair view

A full contact list of Potassium with other atoms in the K binding site number 2 of Structural Insightsinto Potent, Specific Anti-Hiv Property of Actinohivin; Crystal Structure of Actinohivin in Complex with Alpha(1-2) Mannobiose Moiety of High-Mannose Type Glycan of GP120 within 5.0Å range: probe atom residue distance (Å) B Occ A:K205 b:20.1 occ:0.33 O7 A:2M4203 2.9 8.1 0.3 C8 A:2M4203 3.7 6.1 0.3 O8 A:2M4203 4.3 12.2 0.3 C9 A:2M4203 4.7 10.7 0.3 C7 A:2M4203 4.8 11.0 0.3 C6 A:2M4203 4.8 8.6 0.3 O6 A:2M4203 4.9 13.1 0.3

Potassium binding site 3 out of 3 in the Structural Insightsinto Potent, Specific Anti-Hiv Property of Actinohivin; Crystal Structure of Actinohivin in Complex with Alpha(1-2) Mannobiose Moiety of High-Mannose Type Glycan of GP120


Mono view


Stereo pair view

A full contact list of Potassium with other atoms in the K binding site number 3 of Structural Insightsinto Potent, Specific Anti-Hiv Property of Actinohivin; Crystal Structure of Actinohivin in Complex with Alpha(1-2) Mannobiose Moiety of High-Mannose Type Glycan of GP120 within 5.0Å range: probe atom residue distance (Å) B Occ A:K206 b:21.9 occ:1.00 O1 A:2M4202 2.9 9.4 0.3 N A:TYR64 3.4 12.8 0.3 CB A:ASN63 3.5 13.0 0.3 C1 A:2M4202 3.6 8.2 0.3 CD2 A:TYR64 3.8 12.1 0.3 OH A:TYR78 3.9 19.0 0.3 CE1 A:TYR78 3.9 10.3 0.3 CB A:TYR64 4.1 14.0 0.3 CA A:ASN63 4.1 12.7 0.3 CZ A:TYR78 4.2 13.6 0.3 C A:ASN63 4.3 12.9 0.3 CG A:ASN63 4.3 13.0 0.3 CA A:TYR64 4.3 13.6 0.3 CG A:TYR64 4.4 12.7 0.3 ND2 A:ASN63 4.7 16.4 0.3 CE2 A:TYR64 4.8 12.4 0.3 CD1 A:TYR78 4.9 9.1 0.3

M.M.Hoque, K.Suzuki, M.Tsunoda, J.Jiang, F.Zhang, A.Takahashi, N.Ohbayashi, X.Zhang, H.Tanaka, S.Omura, A.Takenaka. Structural Insights Into the Specific Anti-Hiv Property of Actinohivin: Structure of Its Complex with the Alpha(1–2)Mannobiose Moiety of GP120 Acta Crystallogr.,Sect.D V. 68 1671 2012.
ISSN: ISSN 0907-4449
PubMed: 23151632
DOI: 10.1107/S0907444912040498