Potassium in PDB 4a49: Structure of PHOSPHOTYR371-C-Cbl-UBCH5B Complex

All present enzymatic activity of Structure of PHOSPHOTYR371-C-Cbl-UBCH5B Complex:
2.3.2.23; 2.3.2.24; 2.3.2.27;

The structure of Structure of PHOSPHOTYR371-C-Cbl-UBCH5B Complex, PDB code: 4a49 was solved by H.Dou, L.Buetow, A.Hock, G.J.Sibbet, K.H.Vousden, D.T.Huang, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	36.30 / 2.21
Space group	P 32 2 1
Cell size a, b, c (Å), α, β, γ (°)	115.877, 115.877, 52.572, 90.00, 90.00, 120.00
R / Rfree (%)	16.8 / 20.6

The structure of Structure of PHOSPHOTYR371-C-Cbl-UBCH5B Complex also contains other interesting chemical elements:

Zinc

(Zn)

2 atoms

The binding sites of Potassium atom in the Structure of PHOSPHOTYR371-C-Cbl-UBCH5B Complex (pdb code 4a49). This binding sites where shown within 5.0 Angstroms radius around Potassium atom.
In total only one binding site of Potassium was determined in the Structure of PHOSPHOTYR371-C-Cbl-UBCH5B Complex, PDB code: 4a49:

Potassium binding site 1 out of 1 in the Structure of PHOSPHOTYR371-C-Cbl-UBCH5B Complex


Mono view


Stereo pair view

A full contact list of Potassium with other atoms in the K binding site number 1 of Structure of PHOSPHOTYR371-C-Cbl-UBCH5B Complex within 5.0Å range: probe atom residue distance (Å) B Occ B:K1148 b:21.7 occ:0.50 ND1 B:HIS7 2.5 34.6 1.0 CG B:HIS7 3.4 39.5 1.0 CB B:HIS7 3.5 30.2 1.0 CE1 B:HIS7 3.5 28.6 1.0 CA B:HIS7 3.8 26.6 1.0 O B:HIS7 4.5 28.9 1.0 CE B:MET30 4.5 40.2 1.0 CD2 B:HIS7 4.6 36.5 1.0 NE2 B:HIS7 4.6 42.9 1.0 C B:HIS7 4.6 40.1 1.0 CD2 B:LEU10 4.9 33.8 1.0 N B:HIS7 5.0 36.3 1.0

H.Dou, L.Buetow, A.Hock, G.J.Sibbet, K.H.Vousden, D.T.Huang. Structural Basis For Autoinhibition and Phosphorylation-Dependent Activation of C-Cbl. Nat. Struct. Mol. Biol. V. 19 184 2012.
ISSN: ESSN 1545-9985
PubMed: 22266821
DOI: 10.1038/NSMB.2231