Potassium in PDB 4a1o: Crystal Structure of Mycobacterium Tuberculosis Purh Complexed with Aicar and A Novel Nucleotide Cfair, at 2.48 A Resolution.

All present enzymatic activity of Crystal Structure of Mycobacterium Tuberculosis Purh Complexed with Aicar and A Novel Nucleotide Cfair, at 2.48 A Resolution.:
2.1.2.3; 3.5.4.10;

The structure of Crystal Structure of Mycobacterium Tuberculosis Purh Complexed with Aicar and A Novel Nucleotide Cfair, at 2.48 A Resolution., PDB code: 4a1o was solved by J.Le Nours, E.M.M.Bulloch, Z.Zhang, D.R.Greenwood, M.J.Middleditch, J.M.J.Dickson, E.N.Baker, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	43.84 / 2.48
Space group	P 21 21 21
Cell size a, b, c (Å), α, β, γ (°)	75.258, 107.883, 130.924, 90.00, 90.00, 90.00
R / Rfree (%)	18.2 / 22.71

The binding sites of Potassium atom in the Crystal Structure of Mycobacterium Tuberculosis Purh Complexed with Aicar and A Novel Nucleotide Cfair, at 2.48 A Resolution. (pdb code 4a1o). This binding sites where shown within 5.0 Angstroms radius around Potassium atom.
In total 2 binding sites of Potassium where determined in the Crystal Structure of Mycobacterium Tuberculosis Purh Complexed with Aicar and A Novel Nucleotide Cfair, at 2.48 A Resolution., PDB code: 4a1o:
Jump to Potassium binding site number: 1; 2;

Potassium binding site 1 out of 2 in the Crystal Structure of Mycobacterium Tuberculosis Purh Complexed with Aicar and A Novel Nucleotide Cfair, at 2.48 A Resolution.


Mono view


Stereo pair view

A full contact list of Potassium with other atoms in the K binding site number 1 of Crystal Structure of Mycobacterium Tuberculosis Purh Complexed with Aicar and A Novel Nucleotide Cfair, at 2.48 A Resolution. within 5.0Å range: probe atom residue distance (Å) B Occ A:K1524 b:39.0 occ:1.00 O A:VAL424 2.5 36.2 1.0 O A:HIS520 2.6 40.2 1.0 O A:CYS421 2.6 44.0 0.5 O A:CYS421 2.6 44.5 0.5 OD2 A:ASP470 2.7 40.0 1.0 O A:ARG422 2.8 44.5 1.0 C A:ARG422 3.5 43.3 1.0 CG A:ASP470 3.6 37.5 1.0 N A:ALA522 3.6 33.1 1.0 CB A:ASP470 3.7 34.8 1.0 C A:CYS421 3.7 44.7 0.5 C A:CYS421 3.7 44.2 0.5 C A:VAL424 3.7 36.7 1.0 C A:HIS520 3.8 40.0 1.0 CA A:ARG422 3.8 40.0 1.0 CB A:ALA522 3.8 33.3 1.0 C A:PHE521 3.8 38.1 1.0 OG A:SER426 3.9 34.7 1.0 CA A:PHE521 4.0 35.8 1.0 N A:VAL424 4.1 35.2 1.0 N A:ARG422 4.2 41.1 1.0 CB A:ALA428 4.2 35.4 1.0 CA A:ALA522 4.3 33.1 1.0 N A:PHE521 4.4 37.2 1.0 CA A:VAL424 4.4 34.0 1.0 O A:PHE521 4.5 38.9 1.0 N A:ALA423 4.5 38.2 1.0 N A:SER426 4.6 32.6 1.0 O A:ALA522 4.7 39.5 1.0 OD1 A:ASP470 4.7 37.2 1.0 C A:ALA423 4.7 40.5 1.0 N A:LYS425 4.8 32.8 1.0 C A:LYS425 4.8 36.8 1.0 CB A:VAL424 4.8 36.7 1.0 CA A:LYS425 4.9 32.6 1.0 CB A:HIS520 4.9 36.0 1.0 CA A:CYS421 5.0 40.4 0.5 CA A:CYS421 5.0 39.0 0.5 CA A:HIS520 5.0 35.8 1.0

Potassium binding site 2 out of 2 in the Crystal Structure of Mycobacterium Tuberculosis Purh Complexed with Aicar and A Novel Nucleotide Cfair, at 2.48 A Resolution.


Mono view


Stereo pair view

A full contact list of Potassium with other atoms in the K binding site number 2 of Crystal Structure of Mycobacterium Tuberculosis Purh Complexed with Aicar and A Novel Nucleotide Cfair, at 2.48 A Resolution. within 5.0Å range: probe atom residue distance (Å) B Occ B:K1524 b:34.7 occ:1.00 O B:VAL424 2.5 35.5 1.0 O B:HIS520 2.6 34.6 1.0 O B:CYS421 2.6 38.8 0.5 O B:CYS421 2.6 38.2 0.5 OD2 B:ASP470 2.7 39.8 1.0 O B:ARG422 2.8 37.5 1.0 C B:ARG422 3.5 37.7 1.0 CG B:ASP470 3.6 40.5 1.0 N B:ALA522 3.6 34.9 1.0 CB B:ASP470 3.6 34.0 1.0 C B:CYS421 3.7 39.4 0.5 C B:CYS421 3.7 38.8 0.5 C B:VAL424 3.7 35.8 1.0 C B:HIS520 3.8 35.8 1.0 CA B:ARG422 3.8 34.7 1.0 CB B:ALA522 3.8 34.4 1.0 OG B:SER426 3.8 29.2 1.0 C B:PHE521 3.9 36.5 1.0 CA B:PHE521 4.1 31.2 1.0 N B:VAL424 4.1 34.6 1.0 N B:ARG422 4.2 35.0 1.0 CB B:ALA428 4.2 32.5 1.0 CA B:ALA522 4.3 34.8 1.0 N B:PHE521 4.4 32.2 1.0 CA B:VAL424 4.4 33.6 1.0 O B:PHE521 4.5 37.0 1.0 N B:ALA423 4.5 33.7 1.0 N B:SER426 4.6 28.4 1.0 OD1 B:ASP470 4.7 40.9 1.0 C B:ALA423 4.7 38.6 1.0 O B:ALA522 4.7 41.6 1.0 N B:LYS425 4.8 31.7 1.0 C B:LYS425 4.8 34.2 1.0 CB B:VAL424 4.8 37.1 1.0 CA B:LYS425 4.9 31.5 1.0 CB B:HIS520 4.9 33.7 1.0 CA B:CYS421 5.0 35.6 0.5 CA B:CYS421 5.0 34.2 0.5 CA B:HIS520 5.0 33.6 1.0

J.Le Nours, E.M.M.Bulloch, Z.Zhang, D.R.Greenwood, M.J.Middleditch, J.M.J.Dickson, E.N.Baker. Structural Analyses of A Purine Biosynthetic Enzyme From Mycobacterium Tuberculosis Reveal A Novel Bound Nucleotide. J.Biol.Chem. V. 286 40706 2011.
ISSN: ISSN 0021-9258
PubMed: 21956117
DOI: 10.1074/JBC.M111.291138