Potassium in PDB 3vhv: Mineralocorticoid Receptor Ligand-Binding Domain with Non-Steroidal Antagonist

The structure of Mineralocorticoid Receptor Ligand-Binding Domain with Non-Steroidal Antagonist, PDB code: 3vhv was solved by S.Sogabe, N.Habuka, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	40.00 / 1.35
Space group	P 32
Cell size a, b, c (Å), α, β, γ (°)	62.612, 62.612, 75.504, 90.00, 90.00, 120.00
R / Rfree (%)	14.1 / 16.7

The binding sites of Potassium atom in the Mineralocorticoid Receptor Ligand-Binding Domain with Non-Steroidal Antagonist (pdb code 3vhv). This binding sites where shown within 5.0 Angstroms radius around Potassium atom.
In total only one binding site of Potassium was determined in the Mineralocorticoid Receptor Ligand-Binding Domain with Non-Steroidal Antagonist, PDB code: 3vhv:

Potassium binding site 1 out of 1 in the Mineralocorticoid Receptor Ligand-Binding Domain with Non-Steroidal Antagonist


Mono view


Stereo pair view

A full contact list of Potassium with other atoms in the K binding site number 1 of Mineralocorticoid Receptor Ligand-Binding Domain with Non-Steroidal Antagonist within 5.0Å range: probe atom residue distance (Å) B Occ A:K3 b:18.7 occ:1.00 O A:TYR980 2.7 13.9 1.0 O A:ARG983 2.7 17.9 1.0 O A:HOH52 2.8 26.9 1.0 OXT A:LYS984 3.0 30.6 1.0 C A:LYS984 3.6 28.2 1.0 C A:TYR980 3.8 11.5 1.0 C A:ARG983 3.9 17.4 1.0 O A:LYS984 4.0 28.5 1.0 CA A:LYS984 4.3 26.2 1.0 N A:TYR980 4.3 11.4 1.0 CB A:TYR980 4.4 11.8 1.0 CA A:TYR980 4.4 10.4 1.0 N A:LYS984 4.6 21.5 1.0 O A:PHE981 4.6 13.2 1.0 O A:HOH77 4.7 27.8 1.0 N A:PHE981 4.7 10.9 1.0 C A:PHE981 4.8 11.1 1.0 N A:ARG983 4.8 13.4 1.0 CA A:PHE981 4.9 10.8 1.0

T.Hasui, N.Matsunaga, T.Ora, N.Ohyabu, N.Nishigaki, Y.Imura, Y.Igata, H.Matsui, T.Motoyaji, T.Tanaka, N.Habuka, S.Sogabe, M.Ono, C.S.Siedem, T.P.Tang, C.Gauthier, L.A.De Meese, S.A.Boyd, S.Fukumoto. Identification of Benzoxazin-3-One Derivatives As Novel, Potent, and Selective Nonsteroidal Mineralocorticoid Receptor Antagonists J.Med.Chem. V. 54 8616 2011.
ISSN: ISSN 0022-2623
PubMed: 22074142
DOI: 10.1021/JM2011645