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Potassium in PDB 3ukm: Crystal Structure of the Human Two Pore Domain Potassium Ion Channel K2P1 (Twik-1)

Protein crystallography data

The structure of Crystal Structure of the Human Two Pore Domain Potassium Ion Channel K2P1 (Twik-1), PDB code: 3ukm was solved by S.B.Long, A.N.Miller, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 19.91 / 3.40
Space group P 1 21 1
Cell size a, b, c (Å), α, β, γ (°) 82.080, 123.171, 119.305, 90.00, 94.91, 90.00
R / Rfree (%) 27.3 / 27.9

Potassium Binding Sites:

The binding sites of Potassium atom in the Crystal Structure of the Human Two Pore Domain Potassium Ion Channel K2P1 (Twik-1) (pdb code 3ukm). This binding sites where shown within 5.0 Angstroms radius around Potassium atom.
In total 10 binding sites of Potassium where determined in the Crystal Structure of the Human Two Pore Domain Potassium Ion Channel K2P1 (Twik-1), PDB code: 3ukm:
Jump to Potassium binding site number: 1; 2; 3; 4; 5; 6; 7; 8; 9; 10;

Potassium binding site 1 out of 10 in 3ukm

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Potassium binding site 1 out of 10 in the Crystal Structure of the Human Two Pore Domain Potassium Ion Channel K2P1 (Twik-1)


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Stereo pair view

A full contact list of Potassium with other atoms in the K binding site number 1 of Crystal Structure of the Human Two Pore Domain Potassium Ion Channel K2P1 (Twik-1) within 5.0Å range:
probe atom residue distance (Å) B Occ
A:K1

b:0.8
occ:1.00
 O A:TYR120 2.6 0.0 1.0
O B:TYR120 2.6 0.5 1.0
O A:GLY119 3.0 0.2 1.0
O B:LEU228 3.0 0.5 1.0
O A:LEU228 3.0 0.9 1.0
O B:GLY119 3.0 0.2 1.0
O B:GLY227 3.2 0.8 1.0
O A:GLY227 3.2 0.5 1.0
C A:TYR120 3.4 1.0 1.0
C B:TYR120 3.4 0.6 1.0
K A:K2 3.5 0.8 1.0
C B:LEU228 3.7 0.3 1.0
C A:LEU228 3.7 0.9 1.0
CA A:TYR120 4.0 0.0 1.0
CA B:TYR120 4.0 0.9 1.0
C A:GLY119 4.1 0.4 1.0
C B:GLY119 4.2 0.2 1.0
N A:GLY121 4.2 1.0 1.0
N B:GLY121 4.2 0.3 1.0
CA B:LEU228 4.3 0.9 1.0
CA A:LEU228 4.3 0.2 1.0
C B:GLY227 4.3 0.2 1.0
C A:GLY227 4.3 0.5 1.0
CA A:GLY121 4.5 0.4 1.0
CA B:GLY121 4.5 0.2 1.0
N B:GLY229 4.5 0.5 1.0
N A:GLY229 4.5 0.5 1.0
N A:TYR120 4.6 0.1 1.0
N B:TYR120 4.6 0.1 1.0
CA B:GLY229 4.7 0.6 1.0
K A:K5 4.7 0.9 1.0
CA A:GLY229 4.8 0.9 1.0
N B:LEU228 4.8 0.0 1.0
N A:LEU228 4.8 0.8 1.0

Potassium binding site 2 out of 10 in 3ukm

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Potassium binding site 2 out of 10 in the Crystal Structure of the Human Two Pore Domain Potassium Ion Channel K2P1 (Twik-1)


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Stereo pair view

A full contact list of Potassium with other atoms in the K binding site number 2 of Crystal Structure of the Human Two Pore Domain Potassium Ion Channel K2P1 (Twik-1) within 5.0Å range:
probe atom residue distance (Å) B Occ
A:K2

b:0.8
occ:1.00
 O A:THR118 2.6 0.4 1.0
O B:THR118 2.7 0.0 1.0
O B:GLY119 2.8 0.2 1.0
O A:GLY119 2.8 0.2 1.0
O A:GLY227 2.8 0.5 1.0
O B:GLY227 2.9 0.8 1.0
O A:ILE226 2.9 0.8 1.0
O B:ILE226 2.9 0.7 1.0
K A:K3 3.3 0.7 1.0
C A:GLY227 3.5 0.5 1.0
K A:K1 3.5 0.8 1.0
C B:GLY227 3.5 0.2 1.0
C A:GLY119 3.6 0.4 1.0
C B:GLY119 3.6 0.2 1.0
C A:THR118 3.8 0.1 1.0
C B:THR118 3.8 0.4 1.0
CA A:GLY227 3.9 1.0 1.0
C A:ILE226 4.0 0.8 1.0
CA B:GLY227 4.0 0.8 1.0
CA A:GLY119 4.0 0.8 1.0
CA B:GLY119 4.0 0.8 1.0
C B:ILE226 4.0 0.3 1.0
N A:GLY119 4.3 0.8 1.0
N B:GLY119 4.4 0.5 1.0
N A:GLY227 4.4 1.0 1.0
N A:LEU228 4.4 0.8 1.0
N B:LEU228 4.5 0.0 1.0
N B:GLY227 4.5 0.2 1.0
N A:TYR120 4.5 0.1 1.0
N B:TYR120 4.5 0.1 1.0
CA A:TYR120 4.8 0.0 1.0
CA A:LEU228 4.9 0.2 1.0
CA B:TYR120 4.9 0.9 1.0
CA B:LEU228 4.9 0.9 1.0
CA A:THR118 5.0 0.6 1.0

Potassium binding site 3 out of 10 in 3ukm

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Potassium binding site 3 out of 10 in the Crystal Structure of the Human Two Pore Domain Potassium Ion Channel K2P1 (Twik-1)


Mono view


Stereo pair view

A full contact list of Potassium with other atoms in the K binding site number 3 of Crystal Structure of the Human Two Pore Domain Potassium Ion Channel K2P1 (Twik-1) within 5.0Å range:
probe atom residue distance (Å) B Occ
A:K3

b:0.7
occ:1.00
 O A:THR225 2.6 0.9 1.0
O B:THR225 2.7 0.9 1.0
O A:THR118 2.8 0.4 1.0
O B:THR118 2.8 0.0 1.0
O A:THR117 2.8 0.1 1.0
O B:THR117 2.8 0.2 1.0
O B:ILE226 2.9 0.7 1.0
O A:ILE226 2.9 0.8 1.0
K A:K2 3.3 0.8 1.0
C A:THR118 3.5 0.1 1.0
C B:THR118 3.5 0.4 1.0
C A:ILE226 3.6 0.8 1.0
C B:ILE226 3.6 0.3 1.0
K A:K4 3.6 0.7 1.0
C A:THR225 3.7 0.9 1.0
CA A:THR118 3.8 0.6 1.0
C B:THR225 3.8 0.7 1.0
CA B:THR118 3.8 0.1 1.0
C A:THR117 3.9 0.8 1.0
C B:THR117 3.9 0.5 1.0
CA A:ILE226 4.0 0.5 1.0
CA B:ILE226 4.0 0.7 1.0
N A:THR118 4.3 0.9 1.0
N A:ILE226 4.4 0.1 1.0
N B:THR118 4.4 0.2 1.0
N B:ILE226 4.4 0.1 1.0
N A:GLY227 4.5 1.0 1.0
N B:GLY227 4.5 0.2 1.0
N A:GLY119 4.6 0.8 1.0
N B:GLY119 4.6 0.5 1.0
CA A:THR225 4.9 0.6 1.0
CA A:GLY227 4.9 1.0 1.0
CA B:GLY227 4.9 0.8 1.0
CA B:THR225 4.9 0.1 1.0
CB A:THR225 4.9 0.2 1.0
CB B:THR225 5.0 0.5 1.0

Potassium binding site 4 out of 10 in 3ukm

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Potassium binding site 4 out of 10 in the Crystal Structure of the Human Two Pore Domain Potassium Ion Channel K2P1 (Twik-1)


Mono view


Stereo pair view

A full contact list of Potassium with other atoms in the K binding site number 4 of Crystal Structure of the Human Two Pore Domain Potassium Ion Channel K2P1 (Twik-1) within 5.0Å range:
probe atom residue distance (Å) B Occ
A:K4

b:0.7
occ:1.00
 OG1 B:THR225 2.9 0.9 1.0
OG1 A:THR225 2.9 0.6 1.0
OG1 A:THR117 3.0 0.6 1.0
OG1 B:THR117 3.1 96.4 1.0
O B:THR225 3.1 0.9 1.0
O A:THR225 3.1 0.9 1.0
O A:THR117 3.2 0.1 1.0
O B:THR117 3.2 0.2 1.0
CB A:THR225 3.5 0.2 1.0
CB B:THR225 3.5 0.5 1.0
K A:K3 3.6 0.7 1.0
CB A:THR117 3.8 0.8 1.0
CB B:THR117 3.9 0.4 1.0
C B:THR225 4.0 0.7 1.0
C A:THR225 4.0 0.9 1.0
C A:THR117 4.1 0.8 1.0
C B:THR117 4.2 0.5 1.0
CA B:THR225 4.4 0.1 1.0
CA A:THR225 4.4 0.6 1.0
CG2 A:THR225 4.6 0.7 1.0
CG2 B:THR225 4.6 0.8 1.0
CA A:THR117 4.6 0.4 1.0
CA B:THR117 4.7 0.4 1.0
O A:SER116 4.7 0.0 1.0
O B:SER116 4.7 0.6 1.0
O B:SER224 4.9 0.8 1.0
O A:SER224 4.9 0.2 1.0
CG2 A:THR117 5.0 0.6 1.0

Potassium binding site 5 out of 10 in 3ukm

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Potassium binding site 5 out of 10 in the Crystal Structure of the Human Two Pore Domain Potassium Ion Channel K2P1 (Twik-1)


Mono view


Stereo pair view

A full contact list of Potassium with other atoms in the K binding site number 5 of Crystal Structure of the Human Two Pore Domain Potassium Ion Channel K2P1 (Twik-1) within 5.0Å range:
probe atom residue distance (Å) B Occ
A:K5

b:0.9
occ:1.00
 O B:HOH1001 3.3 0.3 1.0
O A:HOH1001 3.3 1.0 1.0
O A:TYR120 4.3 0.0 1.0
O B:TYR120 4.4 0.5 1.0
O A:LEU228 4.6 0.9 1.0
K A:K1 4.7 0.8 1.0
O B:GLY121 4.8 0.3 1.0
O B:LEU228 4.8 0.5 1.0
C B:GLY121 4.9 0.3 1.0
O A:GLY121 4.9 0.3 1.0
C A:GLY121 5.0 0.7 1.0
CA B:GLY121 5.0 0.2 1.0

Potassium binding site 6 out of 10 in 3ukm

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Potassium binding site 6 out of 10 in the Crystal Structure of the Human Two Pore Domain Potassium Ion Channel K2P1 (Twik-1)


Mono view


Stereo pair view

A full contact list of Potassium with other atoms in the K binding site number 6 of Crystal Structure of the Human Two Pore Domain Potassium Ion Channel K2P1 (Twik-1) within 5.0Å range:
probe atom residue distance (Å) B Occ
C:K1

b:0.8
occ:1.00
 O C:TYR120 2.6 0.5 1.0
O D:TYR120 2.6 1.0 1.0
O D:LEU228 3.0 0.5 1.0
O C:GLY119 3.0 0.4 1.0
O D:GLY119 3.0 0.5 1.0
O D:GLY227 3.1 0.8 1.0
O C:LEU228 3.1 0.2 1.0
O C:GLY227 3.2 0.6 1.0
C C:TYR120 3.4 0.7 1.0
C D:TYR120 3.4 0.9 1.0
K C:K2 3.5 0.6 1.0
C D:LEU228 3.6 0.6 1.0
C C:LEU228 3.8 0.9 1.0
CA D:TYR120 4.0 0.1 1.0
CA C:TYR120 4.0 1.0 1.0
C C:GLY119 4.1 0.7 1.0
C D:GLY119 4.1 0.6 1.0
CA D:LEU228 4.2 0.7 1.0
N C:GLY121 4.2 0.9 1.0
C D:GLY227 4.2 0.5 1.0
N D:GLY121 4.3 0.1 1.0
CA C:LEU228 4.3 0.0 1.0
C C:GLY227 4.3 0.6 1.0
N D:GLY229 4.4 0.5 1.0
CA C:GLY121 4.4 0.7 1.0
CA D:GLY121 4.5 0.8 1.0
N C:GLY229 4.6 0.4 1.0
N D:TYR120 4.6 0.2 1.0
N C:TYR120 4.6 0.4 1.0
CA D:GLY229 4.7 0.0 1.0
N D:LEU228 4.7 0.8 1.0
K C:K5 4.8 0.1 1.0
CA C:GLY229 4.8 0.8 1.0
N C:LEU228 4.9 0.2 1.0

Potassium binding site 7 out of 10 in 3ukm

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Potassium binding site 7 out of 10 in the Crystal Structure of the Human Two Pore Domain Potassium Ion Channel K2P1 (Twik-1)


Mono view


Stereo pair view

A full contact list of Potassium with other atoms in the K binding site number 7 of Crystal Structure of the Human Two Pore Domain Potassium Ion Channel K2P1 (Twik-1) within 5.0Å range:
probe atom residue distance (Å) B Occ
C:K2

b:0.6
occ:1.00
 O D:THR118 2.6 0.4 1.0
O C:THR118 2.6 0.3 1.0
O C:GLY119 2.8 0.4 1.0
O D:GLY119 2.8 0.5 1.0
O C:GLY227 2.8 0.6 1.0
O D:GLY227 2.9 0.8 1.0
O D:ILE226 2.9 0.2 1.0
O C:ILE226 2.9 0.7 1.0
K C:K3 3.4 0.2 1.0
K C:K1 3.5 0.8 1.0
C C:GLY227 3.5 0.6 1.0
C D:GLY227 3.5 0.5 1.0
C C:GLY119 3.5 0.7 1.0
C D:GLY119 3.5 0.6 1.0
C D:THR118 3.8 1.0 1.0
C C:THR118 3.8 0.2 1.0
CA C:GLY227 3.9 0.4 1.0
CA D:GLY227 3.9 0.1 1.0
C D:ILE226 4.0 0.4 1.0
CA D:GLY119 4.0 0.8 1.0
CA C:GLY119 4.0 0.4 1.0
C C:ILE226 4.0 0.6 1.0
N D:GLY119 4.3 0.2 1.0
N C:GLY119 4.3 0.7 1.0
N D:GLY227 4.5 0.3 1.0
N C:GLY227 4.5 0.1 1.0
N C:LEU228 4.5 0.2 1.0
N D:LEU228 4.5 0.8 1.0
N C:TYR120 4.5 0.4 1.0
N D:TYR120 4.5 0.2 1.0
CA C:TYR120 4.8 1.0 1.0
CA D:TYR120 4.9 0.1 1.0
CA C:LEU228 4.9 0.0 1.0
CA D:LEU228 4.9 0.7 1.0
CA D:THR118 5.0 0.7 1.0

Potassium binding site 8 out of 10 in 3ukm

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Potassium binding site 8 out of 10 in the Crystal Structure of the Human Two Pore Domain Potassium Ion Channel K2P1 (Twik-1)


Mono view


Stereo pair view

A full contact list of Potassium with other atoms in the K binding site number 8 of Crystal Structure of the Human Two Pore Domain Potassium Ion Channel K2P1 (Twik-1) within 5.0Å range:
probe atom residue distance (Å) B Occ
C:K3

b:0.2
occ:1.00
 O D:THR225 2.6 0.7 1.0
O C:THR225 2.6 0.4 1.0
O D:THR117 2.8 0.7 1.0
O C:THR118 2.8 0.3 1.0
O C:THR117 2.8 0.1 1.0
O D:THR118 2.8 0.4 1.0
O C:ILE226 3.0 0.7 1.0
O D:ILE226 3.0 0.2 1.0
K C:K2 3.4 0.6 1.0
C C:THR118 3.5 0.2 1.0
C D:THR118 3.5 1.0 1.0
C C:ILE226 3.6 0.6 1.0
K C:K4 3.6 0.3 1.0
C D:ILE226 3.6 0.4 1.0
C D:THR225 3.8 0.5 1.0
C C:THR225 3.8 0.1 1.0
CA C:THR118 3.8 0.7 1.0
CA D:THR118 3.8 0.7 1.0
C D:THR117 3.8 0.8 1.0
C C:THR117 3.8 0.8 1.0
CA C:ILE226 4.0 0.8 1.0
CA D:ILE226 4.0 0.5 1.0
N D:THR118 4.3 0.9 1.0
N C:THR118 4.3 0.6 1.0
N C:ILE226 4.4 0.4 1.0
N D:ILE226 4.4 0.9 1.0
N C:GLY227 4.5 0.1 1.0
N D:GLY227 4.6 0.3 1.0
N C:GLY119 4.6 0.7 1.0
N D:GLY119 4.6 0.2 1.0
CA D:THR225 4.9 0.9 1.0
CA C:THR225 4.9 0.9 1.0
CA C:GLY227 4.9 0.4 1.0
CB D:THR225 4.9 0.8 1.0
CB C:THR225 4.9 0.9 1.0
CA D:GLY227 5.0 0.1 1.0

Potassium binding site 9 out of 10 in 3ukm

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Potassium binding site 9 out of 10 in the Crystal Structure of the Human Two Pore Domain Potassium Ion Channel K2P1 (Twik-1)


Mono view


Stereo pair view

A full contact list of Potassium with other atoms in the K binding site number 9 of Crystal Structure of the Human Two Pore Domain Potassium Ion Channel K2P1 (Twik-1) within 5.0Å range:
probe atom residue distance (Å) B Occ
C:K4

b:0.3
occ:1.00
 OG1 C:THR225 2.8 0.7 1.0
OG1 D:THR225 2.9 0.3 1.0
OG1 D:THR117 2.9 0.1 1.0
OG1 C:THR117 3.0 0.9 1.0
O C:THR225 3.1 0.4 1.0
O D:THR117 3.1 0.7 1.0
O D:THR225 3.1 0.7 1.0
O C:THR117 3.2 0.1 1.0
CB C:THR225 3.5 0.9 1.0
CB D:THR225 3.5 0.8 1.0
K C:K3 3.6 0.2 1.0
CB D:THR117 3.7 0.9 1.0
CB C:THR117 3.8 0.2 1.0
C C:THR225 4.0 0.1 1.0
C D:THR225 4.0 0.5 1.0
C D:THR117 4.1 0.8 1.0
C C:THR117 4.1 0.8 1.0
CA C:THR225 4.4 0.9 1.0
CA D:THR225 4.4 0.9 1.0
CG2 D:THR225 4.6 1.0 1.0
CA D:THR117 4.6 0.8 1.0
CG2 C:THR225 4.6 0.7 1.0
O D:SER116 4.6 1.0 1.0
CA C:THR117 4.7 0.5 1.0
O C:SER116 4.7 0.2 1.0
CG2 D:THR117 4.9 0.9 1.0
O C:SER224 4.9 0.2 1.0
O D:SER224 5.0 0.3 1.0

Potassium binding site 10 out of 10 in 3ukm

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Potassium binding site 10 out of 10 in the Crystal Structure of the Human Two Pore Domain Potassium Ion Channel K2P1 (Twik-1)


Mono view


Stereo pair view

A full contact list of Potassium with other atoms in the K binding site number 10 of Crystal Structure of the Human Two Pore Domain Potassium Ion Channel K2P1 (Twik-1) within 5.0Å range:
probe atom residue distance (Å) B Occ
C:K5

b:0.1
occ:1.00
 O D:HOH1001 3.3 0.2 1.0
O C:HOH1001 3.3 1.0 1.0
O D:TYR120 4.3 1.0 1.0
O C:TYR120 4.4 0.5 1.0
O D:LEU228 4.7 0.5 1.0
O C:LEU228 4.7 0.2 1.0
K C:K1 4.8 0.8 1.0
O D:GLY121 4.8 0.3 1.0
O C:GLY121 4.9 0.1 1.0
C D:GLY121 4.9 0.4 1.0
C C:GLY121 4.9 0.7 1.0

Reference:

A.N.Miller, S.B.Long. Crystal Structure of the Human Two-Pore Domain Potassium Channel K2P1. Science V. 335 432 2012.
ISSN: ISSN 0036-8075
PubMed: 22282804
DOI: 10.1126/SCIENCE.1213274
Page generated: Mon Aug 12 09:43:01 2024

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