Potassium in PDB 3tj2: Structure of A Novel Submicromolar MDM2 Inhibitor

The structure of Structure of A Novel Submicromolar MDM2 Inhibitor, PDB code: 3tj2 was solved by S.Wolf, Y.Huang, G.M.Popowicz, S.Goda, T.A.Holak, A.Doemling, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	19.06 / 2.10
Space group	P 1 21 1
Cell size a, b, c (Å), α, β, γ (°)	32.440, 58.880, 49.510, 90.00, 99.21, 90.00
R / Rfree (%)	22.3 / 30.8

The structure of Structure of A Novel Submicromolar MDM2 Inhibitor also contains other interesting chemical elements:

Chlorine

(Cl)

4 atoms

The binding sites of Potassium atom in the Structure of A Novel Submicromolar MDM2 Inhibitor (pdb code 3tj2). This binding sites where shown within 5.0 Angstroms radius around Potassium atom.
In total 2 binding sites of Potassium where determined in the Structure of A Novel Submicromolar MDM2 Inhibitor, PDB code: 3tj2:
Jump to Potassium binding site number: 1; 2;

Potassium binding site 1 out of 2 in the Structure of A Novel Submicromolar MDM2 Inhibitor


Mono view


Stereo pair view

A full contact list of Potassium with other atoms in the K binding site number 1 of Structure of A Novel Submicromolar MDM2 Inhibitor within 5.0Å range: probe atom residue distance (Å) B Occ A:K112 b:21.7 occ:1.00 O A:HOH145 2.7 30.2 1.0 OG1 A:THR47 2.9 21.6 1.0 O A:HOH134 3.1 23.6 1.0 CB A:THR47 4.2 19.4 1.0 CG2 A:THR47 4.7 18.0 1.0

Potassium binding site 2 out of 2 in the Structure of A Novel Submicromolar MDM2 Inhibitor


Mono view


Stereo pair view

A full contact list of Potassium with other atoms in the K binding site number 2 of Structure of A Novel Submicromolar MDM2 Inhibitor within 5.0Å range: probe atom residue distance (Å) B Occ A:K2 b:21.5 occ:1.00 O A:HOH116 3.3 22.1 1.0 N A:LEU33 3.8 15.0 1.0 CB A:LYS31 3.9 20.3 1.0 CB A:LEU33 4.0 15.0 1.0 N A:PRO32 4.0 20.1 1.0 CD A:PRO32 4.0 20.6 1.0 CD2 A:LEU33 4.4 15.0 1.0 C A:LYS31 4.4 20.3 1.0 CA A:LEU33 4.4 15.0 1.0 CB A:PRO32 4.6 19.9 1.0 CA A:PRO32 4.6 20.1 1.0 C A:PRO32 4.6 19.5 1.0 CG A:PRO32 4.7 20.5 1.0 CG A:LEU33 4.7 15.0 1.0 CD A:LYS31 4.7 21.1 1.0 CA A:LYS31 4.8 20.4 1.0 CG A:LYS31 4.9 21.3 1.0

S.Wolf, Y.Huang, G.M.Popowicz, S.Goda, T.A.Holak, A.Doemling. Ugi Multicomponent Reaction Derived P53-MDM2 Antagonists To Be Published.