Atomistry » Potassium » PDB 3rs9-3spj » 3spg
Atomistry »
  Potassium »
    PDB 3rs9-3spj »
      3spg »

Potassium in PDB 3spg: Inward Rectifier Potassium Channel KIR2.2 R186A Mutant in Complex with PIP2

Protein crystallography data

The structure of Inward Rectifier Potassium Channel KIR2.2 R186A Mutant in Complex with PIP2, PDB code: 3spg was solved by S.B.Hansen, X.Tao, R.Mackinnon, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 35.91 / 2.61
Space group I 4
Cell size a, b, c (Å), α, β, γ (°) 81.865, 81.865, 183.102, 90.00, 90.00, 90.00
R / Rfree (%) 19.5 / 24.1

Potassium Binding Sites:

The binding sites of Potassium atom in the Inward Rectifier Potassium Channel KIR2.2 R186A Mutant in Complex with PIP2 (pdb code 3spg). This binding sites where shown within 5.0 Angstroms radius around Potassium atom.
In total 6 binding sites of Potassium where determined in the Inward Rectifier Potassium Channel KIR2.2 R186A Mutant in Complex with PIP2, PDB code: 3spg:
Jump to Potassium binding site number: 1; 2; 3; 4; 5; 6;

Potassium binding site 1 out of 6 in 3spg

Go back to Potassium Binding Sites List in 3spg
Potassium binding site 1 out of 6 in the Inward Rectifier Potassium Channel KIR2.2 R186A Mutant in Complex with PIP2


Mono view


Stereo pair view

A full contact list of Potassium with other atoms in the K binding site number 1 of Inward Rectifier Potassium Channel KIR2.2 R186A Mutant in Complex with PIP2 within 5.0Å range:
probe atom residue distance (Å) B Occ
A:K501

b:63.7
occ:0.25
 O A:TYR146 2.8 69.1 1.0
O A:GLY145 2.8 60.4 1.0
K A:K502 3.1 84.6 0.2
C A:TYR146 3.4 66.6 1.0
C A:GLY145 3.9 62.1 1.0
CA A:TYR146 4.0 65.2 1.0
N A:GLY147 4.2 65.4 1.0
CA A:GLY147 4.5 65.7 1.0
N A:TYR146 4.5 64.4 1.0

Potassium binding site 2 out of 6 in 3spg

Go back to Potassium Binding Sites List in 3spg
Potassium binding site 2 out of 6 in the Inward Rectifier Potassium Channel KIR2.2 R186A Mutant in Complex with PIP2


Mono view


Stereo pair view

A full contact list of Potassium with other atoms in the K binding site number 2 of Inward Rectifier Potassium Channel KIR2.2 R186A Mutant in Complex with PIP2 within 5.0Å range:
probe atom residue distance (Å) B Occ
A:K502

b:84.6
occ:0.25
 O A:GLY145 2.7 60.4 1.0
O A:ILE144 2.8 59.9 1.0
K A:K503 2.8 70.6 0.2
K A:K501 3.1 63.7 0.2
C A:GLY145 3.5 62.1 1.0
C A:ILE144 3.9 59.4 1.0
CA A:GLY145 3.9 60.7 1.0
N A:GLY145 4.4 59.1 1.0
N A:TYR146 4.4 64.4 1.0
CA A:TYR146 4.9 65.2 1.0
O A:THR143 4.9 61.7 1.0

Potassium binding site 3 out of 6 in 3spg

Go back to Potassium Binding Sites List in 3spg
Potassium binding site 3 out of 6 in the Inward Rectifier Potassium Channel KIR2.2 R186A Mutant in Complex with PIP2


Mono view


Stereo pair view

A full contact list of Potassium with other atoms in the K binding site number 3 of Inward Rectifier Potassium Channel KIR2.2 R186A Mutant in Complex with PIP2 within 5.0Å range:
probe atom residue distance (Å) B Occ
A:K503

b:70.6
occ:0.25
 O A:THR143 2.7 61.7 1.0
O A:ILE144 2.7 59.9 1.0
K A:K502 2.8 84.6 0.2
K A:K504 3.3 65.4 0.2
C A:ILE144 3.5 59.4 1.0
C A:THR143 3.8 60.1 1.0
CA A:ILE144 4.0 59.6 1.0
N A:GLY145 4.4 59.1 1.0
N A:ILE144 4.4 59.6 1.0
CA A:GLY145 4.7 60.7 1.0
O A:GLY145 4.9 60.4 1.0
CA A:THR143 5.0 60.0 1.0

Potassium binding site 4 out of 6 in 3spg

Go back to Potassium Binding Sites List in 3spg
Potassium binding site 4 out of 6 in the Inward Rectifier Potassium Channel KIR2.2 R186A Mutant in Complex with PIP2


Mono view


Stereo pair view

A full contact list of Potassium with other atoms in the K binding site number 4 of Inward Rectifier Potassium Channel KIR2.2 R186A Mutant in Complex with PIP2 within 5.0Å range:
probe atom residue distance (Å) B Occ
A:K504

b:65.4
occ:0.25
 OG1 A:THR143 2.7 65.3 1.0
O A:THR143 2.7 61.7 1.0
K A:K503 3.3 70.6 0.2
CB A:THR143 3.6 65.3 1.0
C A:THR143 3.7 60.1 1.0
CA A:THR143 4.3 60.0 1.0
N A:ILE144 4.6 59.6 1.0
O A:THR142 4.7 63.8 1.0
CG2 A:THR143 4.8 62.5 1.0
CA A:ILE144 4.9 59.6 1.0

Potassium binding site 5 out of 6 in 3spg

Go back to Potassium Binding Sites List in 3spg
Potassium binding site 5 out of 6 in the Inward Rectifier Potassium Channel KIR2.2 R186A Mutant in Complex with PIP2


Mono view


Stereo pair view

A full contact list of Potassium with other atoms in the K binding site number 5 of Inward Rectifier Potassium Channel KIR2.2 R186A Mutant in Complex with PIP2 within 5.0Å range:
probe atom residue distance (Å) B Occ
A:K506

b:75.5
occ:0.25
 O A:HOH27 3.2 79.4 1.0
O A:HOH30 3.3 83.9 1.0
CE A:MET181 5.0 89.0 0.5

Potassium binding site 6 out of 6 in 3spg

Go back to Potassium Binding Sites List in 3spg
Potassium binding site 6 out of 6 in the Inward Rectifier Potassium Channel KIR2.2 R186A Mutant in Complex with PIP2


Mono view


Stereo pair view

A full contact list of Potassium with other atoms in the K binding site number 6 of Inward Rectifier Potassium Channel KIR2.2 R186A Mutant in Complex with PIP2 within 5.0Å range:
probe atom residue distance (Å) B Occ
A:K510

b:0.2
occ:0.25
 O A:ASP256 4.6 88.2 1.0

Reference:

S.B.Hansen, X.Tao, R.Mackinnon. Structural Basis of Pip(2) Activation of the Classical Inward Rectifier K(+) Channel KIR2.2. Nature V. 477 495 2011.
ISSN: ISSN 0028-0836
PubMed: 21874019
DOI: 10.1038/NATURE10370
Page generated: Mon Aug 12 09:30:46 2024

Last articles

As in 5NVX
As in 5NVY
As in 5NVW
As in 5NVV
As in 5LLI
As in 5NJ7
As in 5NT5
As in 5NAQ
As in 5NSE
As in 5NJ1
© Copyright 2008-2020 by atomistry.com
Home   |    Site Map   |    Copyright   |    Contact us   |    Privacy