Potassium in PDB 3rde: Crystal Structure of the Catalytic Domain of Porcine Leukocyte 12- Lipoxygenase

All present enzymatic activity of Crystal Structure of the Catalytic Domain of Porcine Leukocyte 12- Lipoxygenase:
1.13.11.31;

The structure of Crystal Structure of the Catalytic Domain of Porcine Leukocyte 12- Lipoxygenase, PDB code: 3rde was solved by M.O.Funk, S.Xu, L.J.Marnett, T.C.Mueser, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	48.97 / 1.89
Space group	P 1 21 1
Cell size a, b, c (Å), α, β, γ (°)	83.450, 181.540, 91.610, 90.00, 92.86, 90.00
R / Rfree (%)	17.2 / 21.4

The structure of Crystal Structure of the Catalytic Domain of Porcine Leukocyte 12- Lipoxygenase also contains other interesting chemical elements:

Iron

(Fe)

4 atoms

The binding sites of Potassium atom in the Crystal Structure of the Catalytic Domain of Porcine Leukocyte 12- Lipoxygenase (pdb code 3rde). This binding sites where shown within 5.0 Angstroms radius around Potassium atom.
In total 2 binding sites of Potassium where determined in the Crystal Structure of the Catalytic Domain of Porcine Leukocyte 12- Lipoxygenase, PDB code: 3rde:
Jump to Potassium binding site number: 1; 2;

Potassium binding site 1 out of 2 in the Crystal Structure of the Catalytic Domain of Porcine Leukocyte 12- Lipoxygenase


Mono view


Stereo pair view

A full contact list of Potassium with other atoms in the K binding site number 1 of Crystal Structure of the Catalytic Domain of Porcine Leukocyte 12- Lipoxygenase within 5.0Å range: probe atom residue distance (Å) B Occ A:K2 b:57.1 occ:1.00 O A:HOH825 2.5 19.6 1.0 O A:HIS483 2.6 17.1 1.0 OD1 A:ASP119 2.8 23.6 1.0 O A:HOH835 3.3 14.9 1.0 OG1 A:THR116 3.6 16.1 1.0 CG A:ASP119 3.6 23.3 1.0 O A:HOH1046 3.6 30.7 1.0 OD2 A:ASP119 3.8 21.9 1.0 C A:HIS483 3.8 16.5 1.0 CG2 A:THR116 4.0 11.9 1.0 CB A:SER489 4.1 14.7 1.0 CD2 A:TYR484 4.1 12.8 1.0 CA A:TYR484 4.2 14.8 1.0 OG A:SER489 4.3 18.2 1.0 N A:TYR484 4.4 13.6 1.0 CE2 A:TYR484 4.4 14.6 1.0 CB A:THR116 4.4 16.3 1.0 CG A:TYR484 4.5 13.8 1.0 CB A:VAL118 4.8 17.3 1.0 O A:SER489 4.9 12.2 1.0 CB A:TYR484 4.9 14.7 1.0 CA A:HIS483 4.9 16.4 1.0 N A:ASP119 5.0 18.9 1.0 CB A:ASP119 5.0 21.1 1.0

Potassium binding site 2 out of 2 in the Crystal Structure of the Catalytic Domain of Porcine Leukocyte 12- Lipoxygenase


Mono view


Stereo pair view

A full contact list of Potassium with other atoms in the K binding site number 2 of Crystal Structure of the Catalytic Domain of Porcine Leukocyte 12- Lipoxygenase within 5.0Å range: probe atom residue distance (Å) B Occ D:K1 b:53.6 occ:1.00 O D:HOH1024 2.5 33.6 1.0 O D:HOH688 2.6 30.1 1.0 O D:LEU282 3.0 17.9 1.0 O D:ILE285 3.0 19.3 1.0 O D:HOH1229 3.1 37.8 1.0 N D:ILE285 3.7 15.8 1.0 CG2 D:VAL299 3.9 17.4 1.0 C D:ILE285 4.0 14.4 1.0 CB D:LEU297 4.1 15.6 1.0 N D:GLY284 4.1 17.8 1.0 C D:LEU282 4.2 18.5 1.0 CD1 D:LEU297 4.2 17.8 1.0 CA D:ILE285 4.2 16.1 1.0 CB D:ILE285 4.4 14.9 1.0 C D:GLY284 4.5 19.6 1.0 CA D:ASP283 4.7 19.5 1.0 CA D:GLY284 4.7 20.0 1.0 C D:ASP283 4.7 19.2 1.0 CG D:LEU297 4.8 13.0 1.0 O D:LEU297 4.8 18.4 1.0 N D:ASP283 4.9 20.4 1.0 O D:HOH1265 4.9 29.9 1.0 O D:ALA298 4.9 15.7 1.0 C D:LEU297 5.0 17.8 1.0

S.Xu, T.C.Mueser, L.J.Marnett, M.O.Funk. Crystal Structure of 12-Lipoxygenase Catalytic-Domain-Inhibitor Complex Identifies A Substrate-Binding Channel For Catalysis. Structure V. 20 1490 2012.
ISSN: ISSN 0969-2126
PubMed: 22795085
DOI: 10.1016/J.STR.2012.06.003