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Potassium in PDB 3rde: Crystal Structure of the Catalytic Domain of Porcine Leukocyte 12- Lipoxygenase

Enzymatic activity of Crystal Structure of the Catalytic Domain of Porcine Leukocyte 12- Lipoxygenase

All present enzymatic activity of Crystal Structure of the Catalytic Domain of Porcine Leukocyte 12- Lipoxygenase:
1.13.11.31;

Protein crystallography data

The structure of Crystal Structure of the Catalytic Domain of Porcine Leukocyte 12- Lipoxygenase, PDB code: 3rde was solved by M.O.Funk, S.Xu, L.J.Marnett, T.C.Mueser, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 48.97 / 1.89
Space group P 1 21 1
Cell size a, b, c (Å), α, β, γ (°) 83.450, 181.540, 91.610, 90.00, 92.86, 90.00
R / Rfree (%) 17.2 / 21.4

Other elements in 3rde:

The structure of Crystal Structure of the Catalytic Domain of Porcine Leukocyte 12- Lipoxygenase also contains other interesting chemical elements:

Iron (Fe) 4 atoms

Potassium Binding Sites:

The binding sites of Potassium atom in the Crystal Structure of the Catalytic Domain of Porcine Leukocyte 12- Lipoxygenase (pdb code 3rde). This binding sites where shown within 5.0 Angstroms radius around Potassium atom.
In total 2 binding sites of Potassium where determined in the Crystal Structure of the Catalytic Domain of Porcine Leukocyte 12- Lipoxygenase, PDB code: 3rde:
Jump to Potassium binding site number: 1; 2;

Potassium binding site 1 out of 2 in 3rde

Go back to Potassium Binding Sites List in 3rde
Potassium binding site 1 out of 2 in the Crystal Structure of the Catalytic Domain of Porcine Leukocyte 12- Lipoxygenase


Mono view


Stereo pair view

A full contact list of Potassium with other atoms in the K binding site number 1 of Crystal Structure of the Catalytic Domain of Porcine Leukocyte 12- Lipoxygenase within 5.0Å range:
probe atom residue distance (Å) B Occ
A:K2

b:57.1
occ:1.00
O A:HOH825 2.5 19.6 1.0
O A:HIS483 2.6 17.1 1.0
OD1 A:ASP119 2.8 23.6 1.0
O A:HOH835 3.3 14.9 1.0
OG1 A:THR116 3.6 16.1 1.0
CG A:ASP119 3.6 23.3 1.0
O A:HOH1046 3.6 30.7 1.0
OD2 A:ASP119 3.8 21.9 1.0
C A:HIS483 3.8 16.5 1.0
CG2 A:THR116 4.0 11.9 1.0
CB A:SER489 4.1 14.7 1.0
CD2 A:TYR484 4.1 12.8 1.0
CA A:TYR484 4.2 14.8 1.0
OG A:SER489 4.3 18.2 1.0
N A:TYR484 4.4 13.6 1.0
CE2 A:TYR484 4.4 14.6 1.0
CB A:THR116 4.4 16.3 1.0
CG A:TYR484 4.5 13.8 1.0
CB A:VAL118 4.8 17.3 1.0
O A:SER489 4.9 12.2 1.0
CB A:TYR484 4.9 14.7 1.0
CA A:HIS483 4.9 16.4 1.0
N A:ASP119 5.0 18.9 1.0
CB A:ASP119 5.0 21.1 1.0

Potassium binding site 2 out of 2 in 3rde

Go back to Potassium Binding Sites List in 3rde
Potassium binding site 2 out of 2 in the Crystal Structure of the Catalytic Domain of Porcine Leukocyte 12- Lipoxygenase


Mono view


Stereo pair view

A full contact list of Potassium with other atoms in the K binding site number 2 of Crystal Structure of the Catalytic Domain of Porcine Leukocyte 12- Lipoxygenase within 5.0Å range:
probe atom residue distance (Å) B Occ
D:K1

b:53.6
occ:1.00
O D:HOH1024 2.5 33.6 1.0
O D:HOH688 2.6 30.1 1.0
O D:LEU282 3.0 17.9 1.0
O D:ILE285 3.0 19.3 1.0
O D:HOH1229 3.1 37.8 1.0
N D:ILE285 3.7 15.8 1.0
CG2 D:VAL299 3.9 17.4 1.0
C D:ILE285 4.0 14.4 1.0
CB D:LEU297 4.1 15.6 1.0
N D:GLY284 4.1 17.8 1.0
C D:LEU282 4.2 18.5 1.0
CD1 D:LEU297 4.2 17.8 1.0
CA D:ILE285 4.2 16.1 1.0
CB D:ILE285 4.4 14.9 1.0
C D:GLY284 4.5 19.6 1.0
CA D:ASP283 4.7 19.5 1.0
CA D:GLY284 4.7 20.0 1.0
C D:ASP283 4.7 19.2 1.0
CG D:LEU297 4.8 13.0 1.0
O D:LEU297 4.8 18.4 1.0
N D:ASP283 4.9 20.4 1.0
O D:HOH1265 4.9 29.9 1.0
O D:ALA298 4.9 15.7 1.0
C D:LEU297 5.0 17.8 1.0

Reference:

S.Xu, T.C.Mueser, L.J.Marnett, M.O.Funk. Crystal Structure of 12-Lipoxygenase Catalytic-Domain-Inhibitor Complex Identifies A Substrate-Binding Channel For Catalysis. Structure V. 20 1490 2012.
ISSN: ISSN 0969-2126
PubMed: 22795085
DOI: 10.1016/J.STR.2012.06.003
Page generated: Sun Dec 13 23:22:18 2020

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