Potassium in PDB 3qe9: Crystal Structure of Human Exonuclease 1 EXO1 (D173A) in Complex with Dna (Complex I)

The structure of Crystal Structure of Human Exonuclease 1 EXO1 (D173A) in Complex with Dna (Complex I), PDB code: 3qe9 was solved by J.Orans, E.A.Mcsweeney, R.R.Iyer, M.A.Hast, H.W.Hellinga, P.Modrich, L.S.Beese, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	50.00 / 2.51
Space group	P 21 21 2
Cell size a, b, c (Å), α, β, γ (°)	92.504, 95.467, 99.777, 90.00, 90.00, 90.00
R / Rfree (%)	21.5 / 23.8

The structure of Crystal Structure of Human Exonuclease 1 EXO1 (D173A) in Complex with Dna (Complex I) also contains other interesting chemical elements:

Calcium

(Ca)

2 atoms

The binding sites of Potassium atom in the Crystal Structure of Human Exonuclease 1 EXO1 (D173A) in Complex with Dna (Complex I) (pdb code 3qe9). This binding sites where shown within 5.0 Angstroms radius around Potassium atom.
In total 2 binding sites of Potassium where determined in the Crystal Structure of Human Exonuclease 1 EXO1 (D173A) in Complex with Dna (Complex I), PDB code: 3qe9:
Jump to Potassium binding site number: 1; 2;

Potassium binding site 1 out of 2 in the Crystal Structure of Human Exonuclease 1 EXO1 (D173A) in Complex with Dna (Complex I)


Mono view


Stereo pair view

A full contact list of Potassium with other atoms in the K binding site number 1 of Crystal Structure of Human Exonuclease 1 EXO1 (D173A) in Complex with Dna (Complex I) within 5.0Å range: probe atom residue distance (Å) B Occ Y:K353 b:98.5 occ:1.00 OP2 C:DA15 2.6 71.5 1.0 OG Y:SER229 2.7 64.2 1.0 O Y:SER222 2.7 56.7 1.0 O Y:ILE233 2.8 67.9 1.0 O C:HOH92 2.9 74.5 1.0 CB Y:SER229 3.6 65.1 1.0 C Y:ILE233 3.9 68.0 1.0 C Y:SER222 3.9 56.8 1.0 O Y:HOH387 3.9 60.8 1.0 P C:DA15 4.0 71.2 1.0 CA Y:GLY234 4.2 64.5 1.0 OP1 C:DA15 4.5 71.1 1.0 N Y:GLY234 4.5 66.4 1.0 CA Y:SER222 4.7 56.0 1.0 O Y:HOH370 4.9 59.4 1.0 O5' C:DA15 4.9 73.3 1.0 N Y:GLY223 4.9 57.7 1.0 C3' C:DT14 4.9 67.8 1.0 O3' C:DT14 4.9 69.9 1.0 CA Y:SER229 5.0 65.2 1.0

Potassium binding site 2 out of 2 in the Crystal Structure of Human Exonuclease 1 EXO1 (D173A) in Complex with Dna (Complex I)


Mono view


Stereo pair view

A full contact list of Potassium with other atoms in the K binding site number 2 of Crystal Structure of Human Exonuclease 1 EXO1 (D173A) in Complex with Dna (Complex I) within 5.0Å range: probe atom residue distance (Å) B Occ Z:K353 b:61.4 occ:1.00 O Z:SER222 2.6 39.9 1.0 O Z:ILE233 2.7 40.8 1.0 OG Z:SER229 2.7 40.1 1.0 O Z:HOH511 2.8 56.1 1.0 OP2 A:DT14 3.0 52.1 1.0 O A:HOH43 3.3 71.0 1.0 CB Z:SER229 3.7 40.9 1.0 C Z:SER222 3.8 39.5 1.0 C Z:ILE233 3.9 41.6 1.0 O A:HOH232 3.9 61.8 1.0 OP1 A:DT14 4.0 51.6 1.0 P A:DT14 4.0 49.6 1.0 O Z:HOH523 4.2 60.1 1.0 CA Z:GLY234 4.2 40.9 1.0 N Z:GLY234 4.5 41.5 1.0 O Z:HOH379 4.5 48.2 1.0 CA Z:SER222 4.6 39.4 1.0 N Z:GLY223 4.8 39.4 1.0 O3' A:DC13 4.9 50.4 1.0 CA Z:GLY223 4.9 39.8 1.0

J.Orans, E.A.Mcsweeney, R.R.Iyer, M.A.Hast, H.W.Hellinga, P.Modrich, L.S.Beese. Structures of Human Exonuclease 1 Dna Complexes Suggest A Unified Mechanism For Nuclease Family. Cell(Cambridge,Mass.) V. 145 212 2011.
ISSN: ISSN 0092-8674
PubMed: 21496642
DOI: 10.1016/J.CELL.2011.03.005