Potassium in PDB 3phc: Crystal Structure of Plasmodium Falciparum Purine Nucleoside Phosphorylase in Complex with Dadme-Immg
Enzymatic activity of Crystal Structure of Plasmodium Falciparum Purine Nucleoside Phosphorylase in Complex with Dadme-Immg
All present enzymatic activity of Crystal Structure of Plasmodium Falciparum Purine Nucleoside Phosphorylase in Complex with Dadme-Immg:
2.4.2.1;
Protein crystallography data
The structure of Crystal Structure of Plasmodium Falciparum Purine Nucleoside Phosphorylase in Complex with Dadme-Immg, PDB code: 3phc
was solved by
M.Ho,
A.A.Edwards,
S.C.Almo,
V.L.Schramm,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Resolution Low / High (Å)
|
20.00 /
2.00
|
Space group
|
P 1
|
Cell size a, b, c (Å), α, β, γ (°)
|
61.197,
77.371,
92.197,
67.71,
73.62,
86.03
|
R / Rfree (%)
|
19.8 /
23.5
|
Potassium Binding Sites:
The binding sites of Potassium atom in the Crystal Structure of Plasmodium Falciparum Purine Nucleoside Phosphorylase in Complex with Dadme-Immg
(pdb code 3phc). This binding sites where shown within
5.0 Angstroms radius around Potassium atom.
In total 3 binding sites of Potassium where determined in the
Crystal Structure of Plasmodium Falciparum Purine Nucleoside Phosphorylase in Complex with Dadme-Immg, PDB code: 3phc:
Jump to Potassium binding site number:
1;
2;
3;
Potassium binding site 1 out
of 3 in 3phc
Go back to
Potassium Binding Sites List in 3phc
Potassium binding site 1 out
of 3 in the Crystal Structure of Plasmodium Falciparum Purine Nucleoside Phosphorylase in Complex with Dadme-Immg
![](/pictures/K/pdb/ph/3phc-K-sphere_01.jpg) Mono view
![](/pictures/K/pdb/ph/3phc-K-sphere_01_stereo.jpg) Stereo pair view
|
A full contact list of Potassium with other atoms in the K binding
site number 1 of Crystal Structure of Plasmodium Falciparum Purine Nucleoside Phosphorylase in Complex with Dadme-Immg within 5.0Å range:
probe
|
atom
|
residue
|
distance (Å)
|
B
|
Occ
|
A:K275
b:29.7
occ:1.00
|
OE1
|
B:GLU46
|
2.7
|
32.5
|
1.0
|
OE1
|
A:GLU46
|
2.7
|
33.2
|
1.0
|
O
|
B:VAL66
|
2.8
|
26.8
|
1.0
|
O
|
A:VAL66
|
2.9
|
26.8
|
1.0
|
O
|
B:HOH304
|
3.1
|
35.1
|
1.0
|
N
|
B:VAL66
|
3.5
|
26.9
|
1.0
|
N
|
A:VAL66
|
3.6
|
26.6
|
1.0
|
O
|
B:HOH277
|
3.7
|
25.5
|
1.0
|
C
|
B:VAL66
|
3.7
|
26.9
|
1.0
|
C
|
A:VAL66
|
3.8
|
26.5
|
1.0
|
CD
|
B:GLU46
|
3.9
|
34.0
|
1.0
|
CD
|
A:GLU46
|
3.9
|
34.4
|
1.0
|
C
|
B:GLY65
|
4.1
|
26.9
|
1.0
|
CA
|
B:VAL66
|
4.1
|
26.9
|
1.0
|
C
|
A:GLY65
|
4.1
|
27.3
|
1.0
|
CA
|
A:GLY65
|
4.2
|
27.0
|
1.0
|
CA
|
A:VAL66
|
4.2
|
26.8
|
1.0
|
CA
|
B:GLY65
|
4.3
|
26.3
|
1.0
|
CA
|
A:GLY70
|
4.4
|
26.1
|
1.0
|
CG
|
A:GLU46
|
4.4
|
32.4
|
1.0
|
CG
|
B:GLU46
|
4.5
|
32.1
|
1.0
|
CA
|
B:GLY70
|
4.5
|
25.9
|
1.0
|
CB
|
B:VAL66
|
4.6
|
27.3
|
1.0
|
CB
|
A:VAL66
|
4.7
|
27.2
|
1.0
|
N
|
B:GLY67
|
4.8
|
26.7
|
1.0
|
O
|
A:HIS64
|
4.9
|
27.8
|
1.0
|
OE2
|
B:GLU46
|
4.9
|
35.0
|
1.0
|
O
|
B:HIS64
|
4.9
|
27.2
|
1.0
|
OE2
|
A:GLU46
|
4.9
|
32.4
|
1.0
|
N
|
A:GLY67
|
4.9
|
26.3
|
1.0
|
N
|
A:GLY70
|
4.9
|
26.4
|
1.0
|
O
|
B:GLY65
|
5.0
|
26.4
|
1.0
|
O
|
A:GLY65
|
5.0
|
27.1
|
1.0
|
|
Potassium binding site 2 out
of 3 in 3phc
Go back to
Potassium Binding Sites List in 3phc
Potassium binding site 2 out
of 3 in the Crystal Structure of Plasmodium Falciparum Purine Nucleoside Phosphorylase in Complex with Dadme-Immg
![](/pictures/K/pdb/ph/3phc-K-sphere_02.jpg) Mono view
![](/pictures/K/pdb/ph/3phc-K-sphere_02_stereo.jpg) Stereo pair view
|
A full contact list of Potassium with other atoms in the K binding
site number 2 of Crystal Structure of Plasmodium Falciparum Purine Nucleoside Phosphorylase in Complex with Dadme-Immg within 5.0Å range:
probe
|
atom
|
residue
|
distance (Å)
|
B
|
Occ
|
C:K275
b:28.4
occ:1.00
|
OE1
|
C:GLU46
|
2.7
|
27.0
|
1.0
|
O
|
C:VAL66
|
2.8
|
21.4
|
1.0
|
O
|
D:VAL66
|
2.8
|
23.5
|
1.0
|
OE1
|
D:GLU46
|
2.8
|
30.3
|
1.0
|
O
|
D:HOH291
|
2.9
|
34.3
|
1.0
|
N
|
D:VAL66
|
3.6
|
22.6
|
1.0
|
N
|
C:VAL66
|
3.6
|
21.5
|
1.0
|
O
|
C:HOH278
|
3.6
|
23.4
|
1.0
|
C
|
D:VAL66
|
3.8
|
23.0
|
1.0
|
C
|
C:VAL66
|
3.8
|
21.3
|
1.0
|
CD
|
C:GLU46
|
3.8
|
29.4
|
1.0
|
CD
|
D:GLU46
|
3.9
|
30.8
|
1.0
|
C
|
D:GLY65
|
4.1
|
22.9
|
1.0
|
CA
|
D:VAL66
|
4.2
|
23.2
|
1.0
|
CA
|
C:VAL66
|
4.2
|
21.6
|
1.0
|
C
|
C:GLY65
|
4.2
|
22.1
|
1.0
|
CA
|
D:GLY65
|
4.3
|
22.3
|
1.0
|
CA
|
C:GLY65
|
4.3
|
22.4
|
1.0
|
CG
|
C:GLU46
|
4.3
|
27.8
|
1.0
|
CG
|
D:GLU46
|
4.4
|
28.5
|
1.0
|
CA
|
C:GLY70
|
4.5
|
23.5
|
1.0
|
CA
|
D:GLY70
|
4.6
|
21.0
|
1.0
|
CB
|
D:VAL66
|
4.6
|
23.1
|
1.0
|
CB
|
C:VAL66
|
4.6
|
21.7
|
1.0
|
OE2
|
C:GLU46
|
4.8
|
31.0
|
1.0
|
O
|
D:HIS64
|
4.9
|
23.4
|
1.0
|
N
|
D:GLY67
|
4.9
|
23.1
|
1.0
|
O
|
C:HIS64
|
4.9
|
24.8
|
1.0
|
N
|
C:GLY67
|
4.9
|
21.3
|
1.0
|
O
|
D:GLY65
|
4.9
|
22.7
|
1.0
|
OE2
|
D:GLU46
|
5.0
|
33.4
|
1.0
|
|
Potassium binding site 3 out
of 3 in 3phc
Go back to
Potassium Binding Sites List in 3phc
Potassium binding site 3 out
of 3 in the Crystal Structure of Plasmodium Falciparum Purine Nucleoside Phosphorylase in Complex with Dadme-Immg
![](/pictures/K/pdb/ph/3phc-K-sphere_03.jpg) Mono view
![](/pictures/K/pdb/ph/3phc-K-sphere_03_stereo.jpg) Stereo pair view
|
A full contact list of Potassium with other atoms in the K binding
site number 3 of Crystal Structure of Plasmodium Falciparum Purine Nucleoside Phosphorylase in Complex with Dadme-Immg within 5.0Å range:
probe
|
atom
|
residue
|
distance (Å)
|
B
|
Occ
|
E:K275
b:24.9
occ:1.00
|
O
|
E:HOH293
|
2.7
|
31.6
|
1.0
|
OE1
|
E:GLU46
|
2.7
|
26.5
|
1.0
|
OE1
|
F:GLU46
|
2.7
|
27.9
|
1.0
|
O
|
E:VAL66
|
2.7
|
19.8
|
1.0
|
O
|
F:VAL66
|
2.9
|
19.6
|
1.0
|
O
|
F:HOH292
|
3.0
|
39.6
|
1.0
|
N
|
E:VAL66
|
3.5
|
21.4
|
1.0
|
N
|
F:VAL66
|
3.5
|
20.5
|
1.0
|
O
|
F:HOH282
|
3.6
|
24.6
|
1.0
|
C
|
E:VAL66
|
3.7
|
20.4
|
1.0
|
C
|
F:VAL66
|
3.8
|
19.7
|
1.0
|
CD
|
F:GLU46
|
3.9
|
28.9
|
1.0
|
CD
|
E:GLU46
|
3.9
|
27.6
|
1.0
|
C
|
E:GLY65
|
4.1
|
22.0
|
1.0
|
C
|
F:GLY65
|
4.1
|
20.9
|
1.0
|
CA
|
F:VAL66
|
4.1
|
20.1
|
1.0
|
CA
|
E:GLY65
|
4.1
|
21.6
|
1.0
|
CA
|
E:VAL66
|
4.1
|
21.2
|
1.0
|
CA
|
F:GLY65
|
4.3
|
20.6
|
1.0
|
CG
|
F:GLU46
|
4.4
|
26.3
|
1.0
|
CG
|
E:GLU46
|
4.4
|
25.5
|
1.0
|
CA
|
F:GLY70
|
4.5
|
23.7
|
1.0
|
CA
|
E:GLY70
|
4.5
|
20.7
|
1.0
|
CB
|
F:VAL66
|
4.5
|
20.1
|
1.0
|
CB
|
E:VAL66
|
4.6
|
21.6
|
1.0
|
N
|
E:GLY67
|
4.8
|
19.5
|
1.0
|
O
|
E:HIS64
|
4.8
|
21.5
|
1.0
|
OE2
|
F:GLU46
|
4.9
|
29.9
|
1.0
|
O
|
F:HIS64
|
4.9
|
22.9
|
1.0
|
OE2
|
E:GLU46
|
4.9
|
26.9
|
1.0
|
N
|
F:GLY67
|
4.9
|
20.0
|
1.0
|
O
|
F:GLY65
|
5.0
|
20.1
|
1.0
|
O
|
E:GLY65
|
5.0
|
21.6
|
1.0
|
|
Reference:
M.Ho,
A.A.Edwards,
S.C.Almo,
V.L.Schramm.
Crystal Structure of Plasmodium Falciparum Purine Nucleoside Phosphorylase in Complex with Dadme-Immg To Be Published.
Page generated: Mon Aug 12 09:01:01 2024
|