Potassium in PDB 3p1d: Crystal Structure of the Bromodomain of Human Crebbp in Complex with N-Methyl-2-Pyrrolidone (Nmp)

Enzymatic activity of Crystal Structure of the Bromodomain of Human Crebbp in Complex with N-Methyl-2-Pyrrolidone (Nmp)

All present enzymatic activity of Crystal Structure of the Bromodomain of Human Crebbp in Complex with N-Methyl-2-Pyrrolidone (Nmp):
2.3.1.48;

Protein crystallography data

The structure of Crystal Structure of the Bromodomain of Human Crebbp in Complex with N-Methyl-2-Pyrrolidone (Nmp), PDB code: 3p1d was solved by P.Filippakopoulos, S.Picaud, I.Feletar, O.Fedorov, J.Muniz, F.Von Delft, C.H.Arrowsmith, A.M.Edwards, J.Weigelt, C.Bountra, S.Knapp, Structuralgenomics Consortium (Sgc), with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

*Resolution Low / High (Å)*	19.76 / 1.86
*Space group*	H 3
*Cell size a, b, c (Å), α, β, γ (°)*	121.549, 121.549, 40.230, 90.00, 90.00, 120.00
*R / R_free (%)*	16.7 / 21.8

Potassium Binding Sites:

The binding sites of Potassium atom in the Crystal Structure of the Bromodomain of Human Crebbp in Complex with N-Methyl-2-Pyrrolidone (Nmp) (pdb code 3p1d). This binding sites where shown within 5.0 Angstroms radius around Potassium atom.
In total only one binding site of Potassium was determined in the Crystal Structure of the Bromodomain of Human Crebbp in Complex with N-Methyl-2-Pyrrolidone (Nmp), PDB code: 3p1d:

Potassium binding site 1 out of 1 in 3p1d

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Potassium Binding Sites List in 3p1d

Potassium binding site 1 out of 1 in the Crystal Structure of the Bromodomain of Human Crebbp in Complex with N-Methyl-2-Pyrrolidone (Nmp)

Mono view

Stereo pair view

A full contact list of Potassium with other atoms in the K binding site number 1 of Crystal Structure of the Bromodomain of Human Crebbp in Complex with N-Methyl-2-Pyrrolidone (Nmp) within 5.0Å range:

probe	atom	residue	distance (Å)	B	Occ
B:K1 b:41.1 occ:1.00	O	B:HOH170	2.7	39.0	1.0
	O	B:ASN1168	2.7	30.3	1.0
	O	B:TRP1165	2.7	26.0	1.0
	O	B:LEU1166	3.1	31.3	1.0
	C	B:ASN1168	3.7	30.8	1.0
	C	B:LEU1166	3.8	30.6	1.0
	C	B:TRP1165	3.9	33.9	1.0
	CA	B:LEU1166	4.2	33.6	1.0
	N	B:ASN1168	4.3	30.6	1.0
	O	B:HOH109	4.4	39.7	1.0
	CE1	B:TYR1175	4.5	31.9	1.0
	CA	B:ARG1169	4.5	38.6	1.0
	N	B:LEU1166	4.5	28.8	1.0
	N	B:ARG1169	4.5	33.6	1.0
	C	B:TYR1167	4.6	34.8	1.0
	CA	B:ASN1168	4.6	32.1	1.0
	N	B:TYR1167	4.7	27.4	1.0
	CD1	B:TYR1175	4.7	28.9	1.0
	C	B:ARG1169	4.9	33.2	1.0
	O	B:TYR1167	5.0	29.1	1.0
	N	B:LYS1170	5.0	31.3	1.0

Reference:

P.Filippakopoulos, S.Picaud, M.Mangos, T.Keates, J.P.Lambert, D.Barsyte-Lovejoy, I.Felletar, R.Volkmer, S.Muller, T.Pawson, A.C.Gingras, C.H.Arrowsmith, S.Knapp. Histone Recognition and Large-Scale Structural Analysis of the Human Bromodomain Family. Cell(Cambridge,Mass.) V. 149 214 2012.
ISSN: ISSN 0092-8674
PubMed: 22464331
DOI: 10.1016/J.CELL.2012.02.013

Page generated: Mon Aug 12 08:59:18 2024

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