Potassium in PDB 3llp: 1.8 Angstrom Human Fascin 1 Crystal Structure

The structure of 1.8 Angstrom Human Fascin 1 Crystal Structure, PDB code: 3llp was solved by L.Chen, S.Yang, J.Jakoncic, J.J.Zhang, X.-Y.Huang, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	29.45 / 1.80
Space group	C 1 2 1
Cell size a, b, c (Å), α, β, γ (°)	159.789, 72.659, 110.142, 90.00, 130.28, 90.00
R / Rfree (%)	17.2 / 22

The structure of 1.8 Angstrom Human Fascin 1 Crystal Structure also contains other interesting chemical elements:

Bromine

(Br)

7 atoms

The binding sites of Potassium atom in the 1.8 Angstrom Human Fascin 1 Crystal Structure (pdb code 3llp). This binding sites where shown within 5.0 Angstroms radius around Potassium atom.
In total 2 binding sites of Potassium where determined in the 1.8 Angstrom Human Fascin 1 Crystal Structure, PDB code: 3llp:
Jump to Potassium binding site number: 1; 2;

Potassium binding site 1 out of 2 in the 1.8 Angstrom Human Fascin 1 Crystal Structure


Mono view


Stereo pair view

A full contact list of Potassium with other atoms in the K binding site number 1 of 1.8 Angstrom Human Fascin 1 Crystal Structure within 5.0Å range: probe atom residue distance (Å) B Occ A:K497 b:21.8 occ:1.00 OE1 A:GLN258 2.6 25.6 1.0 OXT A:TYR493 2.8 17.2 1.0 O A:GLN141 2.8 15.1 1.0 CD2 A:HIS139 2.9 11.6 1.0 O A:HOH659 3.1 24.4 1.0 CG A:HIS139 3.4 14.3 1.0 C A:TYR493 3.5 16.1 1.0 O A:TYR493 3.5 18.9 1.0 CD A:GLN258 3.6 23.9 1.0 NE2 A:HIS139 3.7 17.3 1.0 CB A:HIS139 3.8 14.3 1.0 NH2 A:ARG383 3.8 14.4 1.0 C A:GLN141 3.9 14.2 1.0 NE2 A:GLN258 4.0 22.6 1.0 OD1 A:ASN459 4.1 23.4 1.0 CB A:GLN141 4.2 12.9 1.0 ND1 A:HIS139 4.3 18.1 1.0 N A:GLN141 4.3 13.3 1.0 CA A:GLN141 4.4 13.8 1.0 CE1 A:HIS139 4.4 11.4 1.0 O A:SER259 4.6 16.4 1.0 OE2 A:GLU492 4.6 28.4 1.0 N A:SER259 4.7 14.5 1.0 CA A:TYR493 4.8 15.7 1.0 O A:HIS139 4.9 14.0 1.0 C A:HIS139 4.9 13.2 1.0 CG A:GLU492 4.9 19.4 1.0 CZ A:ARG383 5.0 14.2 1.0 CG A:ASN459 5.0 20.0 1.0 CA A:HIS139 5.0 13.6 1.0

Potassium binding site 2 out of 2 in the 1.8 Angstrom Human Fascin 1 Crystal Structure


Mono view


Stereo pair view

A full contact list of Potassium with other atoms in the K binding site number 2 of 1.8 Angstrom Human Fascin 1 Crystal Structure within 5.0Å range: probe atom residue distance (Å) B Occ B:K497 b:20.7 occ:1.00 O B:THR275 2.7 15.7 1.0 O B:HOH599 2.8 22.3 1.0 O B:ARG276 2.8 19.2 1.0 O B:GLY278 2.9 20.1 1.0 C B:ARG276 3.3 19.0 1.0 N B:GLY278 3.3 20.2 1.0 C B:GLY278 3.7 21.6 1.0 CA B:GLY278 3.7 19.9 1.0 CA B:ARG276 3.8 17.2 1.0 C B:THR275 3.9 16.8 1.0 O B:HOH1310 3.9 41.4 1.0 N B:GLN277 4.1 19.3 1.0 C B:GLN277 4.2 20.5 1.0 N B:ARG276 4.3 16.0 1.0 O B:HOH680 4.3 27.3 1.0 CA B:GLN277 4.5 20.1 0.5 CA B:GLN277 4.5 20.1 0.5 O B:HOH665 4.8 19.3 1.0

L.Chen, S.Yang, J.Jakoncic, J.J.Zhang, X.Y.Huang. Migrastatin Analogues Target Fascin to Block Tumour Metastasis. Nature V. 464 1062 2010.
ISSN: ISSN 0028-0836
PubMed: 20393565
DOI: 10.1038/NATURE08978