Potassium in PDB 3l27: Crystal Structure of Zaire Ebola VP35 Interferon Inhibitory Domain R312A Mutant

The structure of Crystal Structure of Zaire Ebola VP35 Interferon Inhibitory Domain R312A Mutant, PDB code: 3l27 was solved by D.W.Leung, K.C.Prins, D.M.Borek, M.Farahbakhsh, J.M.Tufariello, P.Ramanan, J.C.Nix, L.A.Helgeson, Z.Otwinowski, R.B.Honzatko, C.F.Basler, G.K.Amarasinghe, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	40.79 / 1.95
Space group	P 61 2 2
Cell size a, b, c (Å), α, β, γ (°)	81.549, 81.549, 343.493, 90.00, 90.00, 120.00
R / Rfree (%)	17.6 / 22.9

The structure of Crystal Structure of Zaire Ebola VP35 Interferon Inhibitory Domain R312A Mutant also contains other interesting chemical elements:

Chlorine	(Cl)	6 atoms
Sodium	(Na)	1 atom

The binding sites of Potassium atom in the Crystal Structure of Zaire Ebola VP35 Interferon Inhibitory Domain R312A Mutant (pdb code 3l27). This binding sites where shown within 5.0 Angstroms radius around Potassium atom.
In total 2 binding sites of Potassium where determined in the Crystal Structure of Zaire Ebola VP35 Interferon Inhibitory Domain R312A Mutant, PDB code: 3l27:
Jump to Potassium binding site number: 1; 2;

Potassium binding site 1 out of 2 in the Crystal Structure of Zaire Ebola VP35 Interferon Inhibitory Domain R312A Mutant


Mono view


Stereo pair view

A full contact list of Potassium with other atoms in the K binding site number 1 of Crystal Structure of Zaire Ebola VP35 Interferon Inhibitory Domain R312A Mutant within 5.0Å range: probe atom residue distance (Å) B Occ C:K2 b:21.7 occ:1.00 O C:GLY234 2.5 17.5 1.0 O C:LEU232 2.9 14.9 1.0 N C:GLY234 3.2 18.6 1.0 C C:GLY234 3.5 19.0 1.0 C C:PRO233 3.7 18.1 1.0 CA C:GLY234 3.9 19.6 1.0 C C:LEU232 4.1 14.7 1.0 CA C:PRO233 4.2 18.4 1.0 O C:PRO233 4.4 17.5 1.0 NE2 C:HIS240 4.5 14.0 1.0 N C:PRO233 4.6 16.5 1.0 O C:TYR229 4.6 16.6 1.0 N C:PHE235 4.7 19.4 1.0 CE1 C:HIS240 4.8 13.7 1.0

Potassium binding site 2 out of 2 in the Crystal Structure of Zaire Ebola VP35 Interferon Inhibitory Domain R312A Mutant


Mono view


Stereo pair view

A full contact list of Potassium with other atoms in the K binding site number 2 of Crystal Structure of Zaire Ebola VP35 Interferon Inhibitory Domain R312A Mutant within 5.0Å range: probe atom residue distance (Å) B Occ D:K1 b:20.5 occ:1.00 O D:GLY234 2.5 17.8 1.0 O D:HOH2 2.7 13.2 1.0 O D:LEU232 2.9 15.4 1.0 N D:GLY234 3.3 18.9 1.0 C D:GLY234 3.5 19.8 1.0 O D:HOH151 3.7 37.6 1.0 C D:PRO233 3.7 18.0 1.0 CA D:GLY234 3.9 19.8 1.0 C D:LEU232 4.0 14.3 1.0 CA D:PRO233 4.1 17.1 1.0 O D:PRO233 4.4 17.5 1.0 NE2 D:HIS240 4.5 13.9 1.0 N D:PRO233 4.5 16.5 1.0 O D:HOH344 4.6 30.9 1.0 O D:TYR229 4.7 14.5 1.0 N D:PHE235 4.7 20.9 1.0 CE1 D:HIS240 4.8 12.4 1.0

D.W.Leung, K.C.Prins, D.M.Borek, M.Farahbakhsh, J.M.Tufariello, P.Ramanan, J.C.Nix, L.A.Helgeson, Z.Otwinowski, R.B.Honzatko, C.F.Basler, G.K.Amarasinghe. Structural Basis For Dsrna Recognition and Interferon Antagonism By Ebola VP35. Nat.Struct.Mol.Biol. V. 17 165 2010.
ISSN: ISSN 1545-9993
PubMed: 20081868
DOI: 10.1038/NSMB.1765