Potassium in PDB 3hrz: Cobra Venom Factor (Cvf) in Complex with Human Factor B

All present enzymatic activity of Cobra Venom Factor (Cvf) in Complex with Human Factor B:
3.4.21.47;

The structure of Cobra Venom Factor (Cvf) in Complex with Human Factor B, PDB code: 3hrz was solved by B.J.C.Janssen, L.Gomes, R.I.Koning, D.I.Svergun, A.J.Koster, D.C.Fritzinger, C.-W.Vogel, P.Gros, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	33.49 / 2.20
Space group	C 2 2 21
Cell size a, b, c (Å), α, β, γ (°)	128.890, 283.390, 134.400, 90.00, 90.00, 90.00
R / Rfree (%)	18 / 22.6

The structure of Cobra Venom Factor (Cvf) in Complex with Human Factor B also contains other interesting chemical elements:

Magnesium

(Mg)

2 atoms

The binding sites of Potassium atom in the Cobra Venom Factor (Cvf) in Complex with Human Factor B (pdb code 3hrz). This binding sites where shown within 5.0 Angstroms radius around Potassium atom.
In total only one binding site of Potassium was determined in the Cobra Venom Factor (Cvf) in Complex with Human Factor B, PDB code: 3hrz:

Potassium binding site 1 out of 1 in the Cobra Venom Factor (Cvf) in Complex with Human Factor B


Mono view


Stereo pair view

A full contact list of Potassium with other atoms in the K binding site number 1 of Cobra Venom Factor (Cvf) in Complex with Human Factor B within 5.0Å range: probe atom residue distance (Å) B Occ A:K629 b:49.7 occ:1.00 OH C:TYR1439 2.8 30.1 1.0 OG1 A:THR297 2.8 21.6 1.0 OG A:SER295 2.8 39.8 1.0 O A:SER295 2.9 22.0 1.0 O A:PHE240 2.9 23.2 1.0 C A:SER295 3.2 21.3 1.0 N A:THR297 3.4 20.7 1.0 CE1 C:TYR1439 3.4 27.1 1.0 CZ C:TYR1439 3.5 30.9 1.0 CB A:SER295 3.6 30.2 1.0 CB A:THR297 3.6 22.6 1.0 N A:VAL296 3.6 20.3 1.0 C A:VAL296 3.7 27.1 1.0 CA A:VAL296 3.8 20.1 1.0 C A:PHE240 4.0 24.6 1.0 CA A:SER295 4.0 24.7 1.0 CA A:THR297 4.1 16.8 1.0 O A:HOH782 4.3 45.8 1.0 N A:LEU242 4.4 21.9 1.0 O A:VAL296 4.5 22.9 1.0 CA A:VAL241 4.5 16.3 1.0 O C:HOH267 4.5 34.2 1.0 N A:VAL241 4.6 17.0 1.0 CD1 C:TYR1439 4.7 26.0 1.0 CB A:LEU242 4.8 22.2 1.0 CB A:PHE240 4.8 20.0 1.0 C A:VAL241 4.8 24.7 1.0 CE2 C:TYR1439 4.9 29.2 1.0 CA A:PHE240 5.0 18.6 1.0

B.J.Janssen, L.Gomes, R.I.Koning, D.I.Svergun, A.J.Koster, D.C.Fritzinger, C.W.Vogel, P.Gros. Insights Into Complement Convertase Formation Based on the Structure of the Factor B-Cobra Venom Factor Complex Embo J. V. 28 2469 2009.
ISSN: ISSN 0261-4189
PubMed: 19574954
DOI: 10.1038/EMBOJ.2009.184