Atomistry » Potassium » PDB 3du0-3f2t » 3ezt
Atomistry »
  Potassium »
    PDB 3du0-3f2t »
      3ezt »

Potassium in PDB 3ezt: Crystal Structure Analysis of Human HDAC8 D101E Variant

Enzymatic activity of Crystal Structure Analysis of Human HDAC8 D101E Variant

All present enzymatic activity of Crystal Structure Analysis of Human HDAC8 D101E Variant:
3.5.1.98;

Protein crystallography data

The structure of Crystal Structure Analysis of Human HDAC8 D101E Variant, PDB code: 3ezt was solved by D.P.Dowling, S.L.Gantt, S.G.Gattis, C.A.Fierke, D.W.Christianon, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 46.89 / 2.85
Space group P 1 21 1
Cell size a, b, c (Å), α, β, γ (°) 53.524, 84.664, 94.723, 90.00, 98.06, 90.00
R / Rfree (%) 22.5 / 25.7

Other elements in 3ezt:

The structure of Crystal Structure Analysis of Human HDAC8 D101E Variant also contains other interesting chemical elements:

Zinc (Zn) 2 atoms

Potassium Binding Sites:

The binding sites of Potassium atom in the Crystal Structure Analysis of Human HDAC8 D101E Variant (pdb code 3ezt). This binding sites where shown within 5.0 Angstroms radius around Potassium atom.
In total 4 binding sites of Potassium where determined in the Crystal Structure Analysis of Human HDAC8 D101E Variant, PDB code: 3ezt:
Jump to Potassium binding site number: 1; 2; 3; 4;

Potassium binding site 1 out of 4 in 3ezt

Go back to Potassium Binding Sites List in 3ezt
Potassium binding site 1 out of 4 in the Crystal Structure Analysis of Human HDAC8 D101E Variant


Mono view


Stereo pair view

A full contact list of Potassium with other atoms in the K binding site number 1 of Crystal Structure Analysis of Human HDAC8 D101E Variant within 5.0Å range:
probe atom residue distance (Å) B Occ
A:K403

b:64.1
occ:1.00
O A:PHE189 2.9 73.0 1.0
O A:VAL195 2.9 68.6 1.0
O A:HOH394 3.0 62.8 1.0
O A:TYR225 3.1 80.0 1.0
O A:HOH391 3.2 53.7 1.0
O A:THR192 3.2 74.9 1.0
OG A:SER226 3.5 76.9 1.0
C A:PHE189 3.5 71.6 1.0
C A:TYR225 3.8 79.3 1.0
CB A:TYR225 3.8 82.4 1.0
CB A:PHE189 4.0 67.7 1.0
C A:VAL195 4.1 69.4 1.0
CA A:SER190 4.1 75.1 1.0
N A:SER190 4.1 72.8 1.0
C A:THR192 4.3 74.9 1.0
C A:SER190 4.4 75.0 1.0
CA A:TYR225 4.4 81.1 1.0
CA A:PHE189 4.4 70.0 1.0
CA A:MET196 4.5 67.9 1.0
N A:SER226 4.5 77.6 1.0
O A:GLY222 4.5 86.4 1.0
N A:THR192 4.6 74.4 1.0
N A:THR197 4.6 65.8 1.0
CG2 A:THR197 4.7 65.3 1.0
CG2 A:THR192 4.7 75.0 1.0
CB A:SER226 4.7 74.9 1.0
N A:MET196 4.7 68.2 1.0
N A:PHE191 4.7 74.5 1.0
O A:SER190 4.8 76.3 1.0
CA A:SER226 4.8 75.8 1.0
CA A:THR192 5.0 74.9 1.0

Potassium binding site 2 out of 4 in 3ezt

Go back to Potassium Binding Sites List in 3ezt
Potassium binding site 2 out of 4 in the Crystal Structure Analysis of Human HDAC8 D101E Variant


Mono view


Stereo pair view

A full contact list of Potassium with other atoms in the K binding site number 2 of Crystal Structure Analysis of Human HDAC8 D101E Variant within 5.0Å range:
probe atom residue distance (Å) B Occ
A:K404

b:50.5
occ:1.00
O A:ASP178 2.8 53.2 1.0
O A:HIS180 2.9 51.2 1.0
O A:ASP176 2.9 59.3 1.0
OG A:SER199 3.0 49.3 1.0
OD1 A:ASP176 3.1 55.7 1.0
O A:LEU200 3.2 56.3 1.0
C A:LEU200 3.5 53.9 1.0
C A:ASP176 3.5 57.9 1.0
N A:ASP178 3.5 55.8 1.0
N A:LEU200 3.5 53.4 1.0
CB A:HIS201 3.5 54.1 1.0
CG A:ASP176 3.6 56.3 1.0
CB A:ASP176 3.8 56.1 1.0
C A:ASP178 3.8 53.0 1.0
N A:HIS201 3.9 53.6 1.0
C A:HIS180 3.9 50.4 1.0
C A:LEU177 4.0 56.6 1.0
CA A:HIS201 4.0 54.2 1.0
CB A:SER199 4.0 51.1 1.0
N A:LEU177 4.0 57.9 1.0
CA A:LEU177 4.1 57.6 1.0
C A:SER199 4.1 53.3 1.0
CA A:SER199 4.1 52.3 1.0
CA A:ASP178 4.1 53.4 1.0
CA A:LEU200 4.2 53.5 1.0
CA A:ASP176 4.3 57.0 1.0
CD2 A:HIS201 4.3 48.7 1.0
CG A:HIS201 4.3 51.0 1.0
CA A:HIS181 4.4 50.2 1.0
CB A:ASP178 4.4 52.3 1.0
N A:GLY182 4.4 52.1 1.0
OD2 A:ASP176 4.5 57.7 1.0
N A:HIS181 4.5 50.5 1.0
N A:HIS180 4.7 48.8 1.0
O A:LEU177 4.8 55.9 1.0
C A:LEU179 4.8 50.4 1.0
C A:HIS181 4.8 52.0 1.0
CA A:HIS180 4.9 49.7 1.0
N A:LEU179 4.9 51.8 1.0

Potassium binding site 3 out of 4 in 3ezt

Go back to Potassium Binding Sites List in 3ezt
Potassium binding site 3 out of 4 in the Crystal Structure Analysis of Human HDAC8 D101E Variant


Mono view


Stereo pair view

A full contact list of Potassium with other atoms in the K binding site number 3 of Crystal Structure Analysis of Human HDAC8 D101E Variant within 5.0Å range:
probe atom residue distance (Å) B Occ
B:K405

b:49.2
occ:1.00
O B:ASP178 2.7 51.6 1.0
O B:ASP176 2.9 60.0 1.0
O B:HIS180 2.9 53.0 1.0
OD1 B:ASP176 3.0 56.2 1.0
OG B:SER199 3.1 54.0 1.0
O B:LEU200 3.2 56.6 1.0
N B:ASP178 3.4 56.0 1.0
C B:ASP176 3.4 58.7 1.0
C B:LEU200 3.5 54.2 1.0
N B:LEU200 3.6 54.3 1.0
CG B:ASP176 3.6 56.9 1.0
CB B:HIS201 3.6 54.1 1.0
C B:ASP178 3.6 52.2 1.0
C B:LEU177 3.8 57.6 1.0
CB B:ASP176 3.8 57.6 1.0
N B:HIS201 3.9 53.8 1.0
C B:HIS180 3.9 50.0 1.0
N B:LEU177 3.9 58.2 1.0
CA B:LEU177 3.9 58.5 1.0
CA B:HIS201 4.0 53.3 1.0
CA B:ASP178 4.0 53.9 1.0
CB B:SER199 4.2 53.3 1.0
C B:SER199 4.2 55.6 1.0
CA B:LEU200 4.2 54.2 1.0
CA B:SER199 4.2 54.2 1.0
CA B:ASP176 4.3 58.5 1.0
CB B:ASP178 4.3 52.2 1.0
CG B:HIS201 4.4 52.0 1.0
CD2 B:HIS201 4.4 51.3 1.0
CA B:HIS181 4.5 50.7 1.0
OD2 B:ASP176 4.5 59.2 1.0
N B:GLY182 4.6 52.0 1.0
O B:LEU177 4.6 58.0 1.0
N B:HIS180 4.6 48.8 1.0
N B:HIS181 4.6 49.7 1.0
C B:LEU179 4.7 48.9 1.0
N B:LEU179 4.8 50.2 1.0
CA B:HIS180 4.9 48.4 1.0
C B:HIS181 4.9 51.4 1.0

Potassium binding site 4 out of 4 in 3ezt

Go back to Potassium Binding Sites List in 3ezt
Potassium binding site 4 out of 4 in the Crystal Structure Analysis of Human HDAC8 D101E Variant


Mono view


Stereo pair view

A full contact list of Potassium with other atoms in the K binding site number 4 of Crystal Structure Analysis of Human HDAC8 D101E Variant within 5.0Å range:
probe atom residue distance (Å) B Occ
B:K406

b:80.5
occ:1.00
O B:PHE189 3.0 71.7 1.0
O B:TYR225 3.0 81.2 1.0
O B:VAL195 3.1 69.8 1.0
O B:THR192 3.1 77.4 1.0
OG B:SER226 3.4 78.1 1.0
CB B:TYR225 3.6 84.2 1.0
C B:TYR225 3.6 81.7 1.0
C B:PHE189 3.7 71.2 1.0
CA B:SER190 4.0 76.2 1.0
N B:SER190 4.2 73.9 1.0
CA B:TYR225 4.2 82.7 1.0
C B:VAL195 4.2 70.4 1.0
O B:GLY222 4.2 87.8 1.0
CB B:PHE189 4.3 68.2 1.0
C B:THR192 4.3 76.7 1.0
C B:SER190 4.3 76.1 1.0
N B:SER226 4.4 80.5 1.0
N B:THR192 4.5 75.2 1.0
CB B:SER226 4.6 77.9 1.0
O B:SER190 4.6 76.3 1.0
CA B:PHE189 4.6 69.6 1.0
CA B:MET196 4.6 70.3 1.0
N B:PHE191 4.7 76.1 1.0
CA B:SER226 4.7 78.2 1.0
CA B:GLY222 4.7 85.8 1.0
CG2 B:THR192 4.8 76.7 1.0
N B:THR197 4.8 66.7 1.0
CG B:TYR225 4.9 84.9 1.0
CG2 B:THR197 4.9 64.7 1.0
N B:MET196 4.9 70.4 1.0
C B:GLY222 4.9 86.6 1.0
CA B:THR192 5.0 76.1 1.0

Reference:

D.P.Dowling, S.L.Gantt, S.G.Gattis, C.A.Fierke, D.W.Christianson. Structural Studies of Human Histone Deacetylase 8 and Its Site-Specific Variants Complexed with Substrate and Inhibitors. Biochemistry V. 47 13554 2008.
ISSN: ISSN 0006-2960
PubMed: 19053282
DOI: 10.1021/BI801610C
Page generated: Sun Dec 13 23:18:10 2020

Last articles

Zn in 8WB0
Zn in 8WAX
Zn in 8WAU
Zn in 8WAZ
Zn in 8WAY
Zn in 8WAV
Zn in 8WAW
Zn in 8WAT
Zn in 8W7M
Zn in 8WD3
© Copyright 2008-2020 by atomistry.com
Home   |    Site Map   |    Copyright   |    Contact us   |    Privacy