Atomistry » Potassium » PDB 3du0-3f2t » 3ezp
Atomistry »
  Potassium »
    PDB 3du0-3f2t »
      3ezp »

Potassium in PDB 3ezp: Crystal Structure Analysis of Human HDAC8 D101N Variant

Enzymatic activity of Crystal Structure Analysis of Human HDAC8 D101N Variant

All present enzymatic activity of Crystal Structure Analysis of Human HDAC8 D101N Variant:
3.5.1.98;

Protein crystallography data

The structure of Crystal Structure Analysis of Human HDAC8 D101N Variant, PDB code: 3ezp was solved by D.P.Dowling, S.L.Gantt, S.G.Gattis, C.A.Fierke, D.W.Christianon, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 47.23 / 2.65
Space group P 1 21 1
Cell size a, b, c (Å), α, β, γ (°) 55.310, 85.874, 94.642, 90.00, 93.60, 90.00
R / Rfree (%) 22.5 / 26.2

Other elements in 3ezp:

The structure of Crystal Structure Analysis of Human HDAC8 D101N Variant also contains other interesting chemical elements:

Zinc (Zn) 2 atoms

Potassium Binding Sites:

The binding sites of Potassium atom in the Crystal Structure Analysis of Human HDAC8 D101N Variant (pdb code 3ezp). This binding sites where shown within 5.0 Angstroms radius around Potassium atom.
In total 4 binding sites of Potassium where determined in the Crystal Structure Analysis of Human HDAC8 D101N Variant, PDB code: 3ezp:
Jump to Potassium binding site number: 1; 2; 3; 4;

Potassium binding site 1 out of 4 in 3ezp

Go back to Potassium Binding Sites List in 3ezp
Potassium binding site 1 out of 4 in the Crystal Structure Analysis of Human HDAC8 D101N Variant


Mono view


Stereo pair view

A full contact list of Potassium with other atoms in the K binding site number 1 of Crystal Structure Analysis of Human HDAC8 D101N Variant within 5.0Å range:
probe atom residue distance (Å) B Occ
A:K402

b:60.5
occ:1.00
 O A:HIS180 2.6 51.5 1.0
O A:ASP178 2.6 57.5 1.0
O A:ASP176 2.8 58.2 1.0
OG A:SER199 2.9 57.6 1.0
OD1 A:ASP176 2.9 57.8 1.0
O A:LEU200 3.2 59.6 1.0
N A:ASP178 3.4 56.0 1.0
CG A:ASP176 3.5 59.4 1.0
CB A:HIS201 3.5 54.8 1.0
C A:LEU200 3.5 58.1 1.0
C A:ASP176 3.5 57.8 1.0
C A:ASP178 3.5 55.4 1.0
C A:HIS180 3.6 49.4 1.0
CB A:ASP176 3.7 56.6 1.0
N A:LEU200 3.8 57.8 1.0
N A:HIS201 3.8 57.0 1.0
CA A:HIS201 3.9 57.7 1.0
CA A:ASP178 3.9 54.9 1.0
CB A:ASP178 4.0 55.4 1.0
CB A:SER199 4.1 58.1 1.0
C A:LEU177 4.2 56.5 1.0
ND1 A:HIS201 4.2 52.5 1.0
C A:SER199 4.3 58.5 1.0
N A:LEU177 4.3 56.6 1.0
CA A:ASP176 4.3 56.6 1.0
CG A:HIS201 4.3 51.2 1.0
CA A:HIS181 4.3 52.2 1.0
N A:HIS180 4.3 50.0 1.0
CA A:SER199 4.3 58.7 1.0
N A:HIS181 4.3 51.0 1.0
CA A:LEU200 4.4 58.2 1.0
OD2 A:ASP176 4.4 61.2 1.0
CA A:LEU177 4.4 56.1 1.0
N A:GLY182 4.4 56.5 1.0
CA A:HIS180 4.5 46.5 1.0
C A:LEU179 4.7 51.8 1.0
N A:LEU179 4.7 52.4 1.0
C A:HIS181 4.8 54.6 1.0
O A:HOH391 5.0 53.6 1.0
CE1 A:HIS142 5.0 58.1 1.0

Potassium binding site 2 out of 4 in 3ezp

Go back to Potassium Binding Sites List in 3ezp
Potassium binding site 2 out of 4 in the Crystal Structure Analysis of Human HDAC8 D101N Variant


Mono view


Stereo pair view

A full contact list of Potassium with other atoms in the K binding site number 2 of Crystal Structure Analysis of Human HDAC8 D101N Variant within 5.0Å range:
probe atom residue distance (Å) B Occ
A:K403

b:66.2
occ:1.00
 O A:PHE189 2.5 76.2 1.0
O A:TYR225 2.5 76.1 1.0
O A:HOH396 2.6 77.1 1.0
O A:VAL195 2.7 69.5 1.0
O A:THR192 2.9 80.0 1.0
C A:PHE189 3.5 76.7 1.0
C A:TYR225 3.6 76.4 1.0
CB A:TYR225 3.8 81.5 1.0
C A:VAL195 3.8 71.0 1.0
CB A:PHE189 3.9 75.4 1.0
OG A:SER226 4.0 68.4 1.0
C A:THR192 4.1 78.8 1.0
CA A:MET196 4.2 69.9 1.0
N A:SER190 4.3 77.2 1.0
CA A:SER190 4.3 78.3 1.0
CA A:TYR225 4.3 78.3 1.0
CA A:PHE189 4.3 75.3 1.0
N A:THR197 4.4 68.2 1.0
N A:MET196 4.5 69.9 1.0
N A:SER226 4.5 73.8 1.0
CG2 A:THR192 4.6 79.2 1.0
C A:SER190 4.6 78.7 1.0
N A:THR192 4.7 78.9 1.0
O A:GLY222 4.8 84.0 1.0
O A:SER190 4.8 79.0 1.0
C A:MET196 4.8 70.2 1.0
CA A:SER226 4.8 70.9 1.0
CG2 A:THR197 4.8 64.1 1.0
OG1 A:THR197 4.9 65.9 1.0
CB A:SER226 4.9 69.5 1.0
CA A:THR192 4.9 78.9 1.0
CA A:VAL195 5.0 72.4 1.0

Potassium binding site 3 out of 4 in 3ezp

Go back to Potassium Binding Sites List in 3ezp
Potassium binding site 3 out of 4 in the Crystal Structure Analysis of Human HDAC8 D101N Variant


Mono view


Stereo pair view

A full contact list of Potassium with other atoms in the K binding site number 3 of Crystal Structure Analysis of Human HDAC8 D101N Variant within 5.0Å range:
probe atom residue distance (Å) B Occ
B:K405

b:59.1
occ:1.00
 O B:ASP178 2.5 57.1 1.0
O B:HIS180 2.7 48.1 1.0
O B:ASP176 2.8 58.7 1.0
OD1 B:ASP176 3.0 54.3 1.0
OG B:SER199 3.0 56.9 1.0
O B:LEU200 3.2 59.4 1.0
C B:LEU200 3.4 57.5 1.0
N B:ASP178 3.4 57.9 1.0
CB B:HIS201 3.5 54.0 1.0
C B:ASP178 3.5 54.9 1.0
C B:ASP176 3.6 57.3 1.0
CG B:ASP176 3.6 56.2 1.0
C B:HIS180 3.6 45.2 1.0
N B:HIS201 3.7 56.7 1.0
N B:LEU200 3.7 55.6 1.0
CA B:HIS201 3.8 55.6 1.0
CB B:ASP176 3.9 54.8 1.0
CA B:ASP178 3.9 56.0 1.0
CB B:ASP178 4.1 56.0 1.0
C B:LEU177 4.1 57.7 1.0
ND1 B:HIS201 4.2 49.8 1.0
CB B:SER199 4.2 57.4 1.0
CA B:LEU200 4.2 56.9 1.0
C B:SER199 4.2 56.0 1.0
N B:LEU177 4.3 56.2 1.0
N B:HIS180 4.3 45.5 1.0
CG B:HIS201 4.3 50.5 1.0
CA B:LEU177 4.3 56.6 1.0
CA B:ASP176 4.4 56.0 1.0
N B:HIS181 4.4 46.3 1.0
CA B:SER199 4.4 56.9 1.0
CA B:HIS181 4.4 48.4 1.0
OD2 B:ASP176 4.5 57.3 1.0
CA B:HIS180 4.6 42.3 1.0
N B:GLY182 4.6 53.1 1.0
C B:LEU179 4.6 49.5 1.0
N B:LEU179 4.6 51.3 1.0
C B:HIS181 4.9 52.2 1.0
O B:LEU177 4.9 60.3 1.0

Potassium binding site 4 out of 4 in 3ezp

Go back to Potassium Binding Sites List in 3ezp
Potassium binding site 4 out of 4 in the Crystal Structure Analysis of Human HDAC8 D101N Variant


Mono view


Stereo pair view

A full contact list of Potassium with other atoms in the K binding site number 4 of Crystal Structure Analysis of Human HDAC8 D101N Variant within 5.0Å range:
probe atom residue distance (Å) B Occ
B:K406

b:61.6
occ:1.00
 O B:VAL195 2.4 66.2 1.0
O B:PHE189 2.5 74.5 1.0
O B:TYR225 2.7 73.7 1.0
O B:HOH390 2.8 60.1 1.0
O B:THR192 2.8 77.2 1.0
O B:HOH398 3.1 62.4 1.0
C B:PHE189 3.5 74.3 1.0
C B:VAL195 3.6 68.2 1.0
CB B:PHE189 3.7 74.2 1.0
C B:TYR225 3.7 74.7 1.0
CB B:TYR225 3.8 79.9 1.0
C B:THR192 4.0 77.8 1.0
CA B:MET196 4.1 68.8 1.0
OG B:SER226 4.2 68.2 1.0
CA B:PHE189 4.3 73.9 1.0
N B:MET196 4.4 67.5 1.0
N B:SER190 4.4 74.4 1.0
CG2 B:THR192 4.4 78.3 1.0
N B:THR197 4.4 67.1 1.0
CA B:SER190 4.4 75.1 1.0
CA B:TYR225 4.4 76.6 1.0
N B:THR192 4.7 76.4 1.0
N B:SER226 4.7 72.4 1.0
CA B:VAL195 4.7 69.4 1.0
C B:SER190 4.7 74.6 1.0
C B:MET196 4.8 69.0 1.0
CA B:THR192 4.8 77.1 1.0
CG2 B:THR197 4.9 63.6 1.0
N B:VAL195 4.9 72.0 1.0
O B:SER190 4.9 74.7 1.0
N B:SER193 4.9 77.3 1.0
CB B:VAL195 4.9 69.6 1.0
O B:GLY222 5.0 83.1 1.0
OG1 B:THR197 5.0 60.7 1.0

Reference:

D.P.Dowling, S.L.Gantt, S.G.Gattis, C.A.Fierke, D.W.Christianson. Structural Studies of Human Histone Deacetylase 8 and Its Site-Specific Variants Complexed with Substrate and Inhibitors. Biochemistry V. 47 13554 2008.
ISSN: ISSN 0006-2960
PubMed: 19053282
DOI: 10.1021/BI801610C
Page generated: Mon Aug 12 08:13:13 2024

Last articles

Zn in 9JPJ
Zn in 9JP7
Zn in 9JPK
Zn in 9JPL
Zn in 9GN6
Zn in 9GN7
Zn in 9GKU
Zn in 9GKW
Zn in 9GKX
Zn in 9GL0
© Copyright 2008-2020 by atomistry.com
Home   |    Site Map   |    Copyright   |    Contact us   |    Privacy