Potassium in PDB 3ccu: Structure of Anisomycin Resistant 50S Ribosomal Subunit: 23S Rrna Mutation G2482C

The structure of Structure of Anisomycin Resistant 50S Ribosomal Subunit: 23S Rrna Mutation G2482C, PDB code: 3ccu was solved by G.Blaha, G.Gurel, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	49.99 / 2.80
Space group	C 2 2 21
Cell size a, b, c (Å), α, β, γ (°)	211.756, 299.274, 574.365, 90.00, 90.00, 90.00
R / Rfree (%)	17.9 / 22.3

The structure of Structure of Anisomycin Resistant 50S Ribosomal Subunit: 23S Rrna Mutation G2482C also contains other interesting chemical elements:

Strontium	(Sr)	108 atoms
Magnesium	(Mg)	93 atoms
Cadmium	(Cd)	5 atoms
Chlorine	(Cl)	22 atoms
Sodium	(Na)	75 atoms

The binding sites of Potassium atom in the Structure of Anisomycin Resistant 50S Ribosomal Subunit: 23S Rrna Mutation G2482C (pdb code 3ccu). This binding sites where shown within 5.0 Angstroms radius around Potassium atom.
In total 2 binding sites of Potassium where determined in the Structure of Anisomycin Resistant 50S Ribosomal Subunit: 23S Rrna Mutation G2482C, PDB code: 3ccu:
Jump to Potassium binding site number: 1; 2;

Potassium binding site 1 out of 2 in the Structure of Anisomycin Resistant 50S Ribosomal Subunit: 23S Rrna Mutation G2482C


Mono view


Stereo pair view

A full contact list of Potassium with other atoms in the K binding site number 1 of Structure of Anisomycin Resistant 50S Ribosomal Subunit: 23S Rrna Mutation G2482C within 5.0Å range: probe atom residue distance (Å) B Occ 0:K8401 b:0.6 occ:1.00 OP1 0:U2539 2.7 49.9 1.0 O6 0:G2102 2.9 83.7 1.0 N7 0:G2102 3.3 82.0 1.0 N4 0:C2482 3.4 52.4 1.0 C6 0:G2102 3.6 83.5 1.0 O3' 0:A2538 3.6 59.3 1.0 C5 0:G2102 3.7 83.2 1.0 P 0:U2539 3.7 51.3 1.0 O4' 0:A2538 4.0 69.9 1.0 O2 0:U2535 4.0 42.7 1.0 C4' 0:A2538 4.0 66.8 1.0 O2' 0:U2535 4.1 45.6 1.0 C4' 0:C2536 4.2 48.8 1.0 O4' 0:C2536 4.2 47.7 1.0 O 0:HOH9228 4.3 33.6 1.0 C5' 0:C2536 4.3 48.0 1.0 C2' 0:U2535 4.4 46.9 1.0 C3' 0:A2538 4.4 64.9 1.0 C8 0:G2102 4.5 82.7 1.0 C4 0:C2482 4.5 51.0 1.0 C1' 0:A2538 4.5 72.4 1.0 O5' 0:U2539 4.6 51.4 1.0 C5 0:C2482 4.7 50.9 1.0 C2 0:U2535 4.8 43.2 1.0 N1 0:G2102 4.9 82.3 1.0 OP2 0:U2539 4.9 52.7 1.0 C1' 0:C2536 5.0 45.8 1.0

Potassium binding site 2 out of 2 in the Structure of Anisomycin Resistant 50S Ribosomal Subunit: 23S Rrna Mutation G2482C


Mono view


Stereo pair view

A full contact list of Potassium with other atoms in the K binding site number 2 of Structure of Anisomycin Resistant 50S Ribosomal Subunit: 23S Rrna Mutation G2482C within 5.0Å range: probe atom residue distance (Å) B Occ 0:K8402 b:69.5 occ:1.00 O 0:HOH9020 2.9 21.4 1.0 O4 0:U163 2.9 30.6 1.0 O4 0:U172 3.0 33.7 1.0 O 0:HOH9120 3.1 33.1 1.0 OP2 0:C162 3.1 21.4 1.0 O 0:HOH4960 3.1 52.2 1.0 O 0:HOH9155 3.2 18.8 1.0 O 0:HOH7854 3.4 32.5 1.0 CD M:ARG82 3.4 40.5 1.0 C4 0:U172 3.9 31.6 1.0 O 0:HOH9329 3.9 33.8 1.0 N3 0:U172 4.0 31.6 1.0 C4 0:U163 4.0 28.7 1.0 O 0:HOH7853 4.2 45.6 1.0 NE M:ARG82 4.2 41.7 1.0 P 0:C162 4.4 22.5 1.0 N4 0:C171 4.4 27.8 1.0 C5 0:U163 4.5 28.4 1.0 CG M:ARG82 4.5 40.7 1.0 OP2 0:A169 4.6 23.6 1.0 O6 0:G164 4.7 26.5 1.0 CB M:ARG82 4.8 38.5 1.0 OP1 0:C162 4.8 21.4 1.0 N3 0:C173 4.9 30.1 1.0 OP1 0:A169 4.9 25.3 1.0 MG 0:MG8041 5.0 25.2 1.0

G.Blaha, G.Gurel, S.J.Schroeder, P.B.Moore, T.A.Steitz. Mutations Outside the Anisomycin-Binding Site Can Make Ribosomes Drug-Resistant. J.Mol.Biol. V. 379 505 2008.
ISSN: ISSN 0022-2836
PubMed: 18455733
DOI: 10.1016/J.JMB.2008.03.075