Potassium in PDB 3cce: Structure of Anisomycin Resistant 50S Ribosomal Subunit: 23S Rrna Mutation U2535A

The structure of Structure of Anisomycin Resistant 50S Ribosomal Subunit: 23S Rrna Mutation U2535A, PDB code: 3cce was solved by G.Blaha, G.Gurel, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	49.33 / 2.75
Space group	C 2 2 21
Cell size a, b, c (Å), α, β, γ (°)	212.832, 299.896, 576.013, 90.00, 90.00, 90.00
R / Rfree (%)	18.3 / 23.2

The structure of Structure of Anisomycin Resistant 50S Ribosomal Subunit: 23S Rrna Mutation U2535A also contains other interesting chemical elements:

Strontium	(Sr)	108 atoms
Magnesium	(Mg)	93 atoms
Cadmium	(Cd)	5 atoms
Chlorine	(Cl)	22 atoms
Sodium	(Na)	75 atoms

The binding sites of Potassium atom in the Structure of Anisomycin Resistant 50S Ribosomal Subunit: 23S Rrna Mutation U2535A (pdb code 3cce). This binding sites where shown within 5.0 Angstroms radius around Potassium atom.
In total 2 binding sites of Potassium where determined in the Structure of Anisomycin Resistant 50S Ribosomal Subunit: 23S Rrna Mutation U2535A, PDB code: 3cce:
Jump to Potassium binding site number: 1; 2;

Potassium binding site 1 out of 2 in the Structure of Anisomycin Resistant 50S Ribosomal Subunit: 23S Rrna Mutation U2535A


Mono view


Stereo pair view

A full contact list of Potassium with other atoms in the K binding site number 1 of Structure of Anisomycin Resistant 50S Ribosomal Subunit: 23S Rrna Mutation U2535A within 5.0Å range: probe atom residue distance (Å) B Occ 0:K8401 b:0.9 occ:1.00 OP1 0:U2539 2.8 57.0 1.0 O6 0:G2102 3.2 76.8 1.0 N3 0:A2535 3.5 63.9 1.0 O2' 0:A2535 3.6 64.0 1.0 C2' 0:A2535 3.6 65.0 1.0 O6 0:G2482 3.7 53.1 1.0 N7 0:G2482 3.9 51.7 1.0 C2 0:A2535 4.0 63.8 1.0 C6 0:G2102 4.2 76.3 1.0 C4 0:A2535 4.2 64.2 1.0 P 0:U2539 4.3 58.2 1.0 O4' 0:C2536 4.3 57.9 1.0 C6 0:G2482 4.4 51.8 1.0 C1' 0:A2535 4.4 64.5 1.0 N7 0:G2102 4.4 75.2 1.0 C5 0:G2482 4.5 51.9 1.0 N9 0:A2535 4.6 64.0 1.0 C5' 0:C2536 4.7 59.5 1.0 C4' 0:C2536 4.7 59.0 1.0 C5 0:G2102 4.7 76.1 1.0 O3' 0:A2538 4.8 64.7 1.0 O 0:HOH4805 4.8 66.6 1.0 O5' 0:U2539 4.9 56.6 1.0 C3' 0:A2535 4.9 65.0 1.0 N6 0:A2486 5.0 75.4 1.0 C5 0:U2539 5.0 45.5 1.0 C6 0:U2539 5.0 43.9 1.0

Potassium binding site 2 out of 2 in the Structure of Anisomycin Resistant 50S Ribosomal Subunit: 23S Rrna Mutation U2535A


Mono view


Stereo pair view

A full contact list of Potassium with other atoms in the K binding site number 2 of Structure of Anisomycin Resistant 50S Ribosomal Subunit: 23S Rrna Mutation U2535A within 5.0Å range: probe atom residue distance (Å) B Occ 0:K8402 b:63.2 occ:1.00 O4 0:U172 2.9 32.8 1.0 O 0:HOH9021 3.0 17.9 1.0 O 0:HOH9121 3.0 40.4 1.0 O 0:HOH9157 3.0 17.5 1.0 O 0:HOH4962 3.1 22.5 1.0 O4 0:U163 3.1 29.7 1.0 OP2 0:C162 3.2 21.3 1.0 O 0:HOH7846 3.2 36.0 1.0 CD M:ARG82 3.3 35.9 1.0 C4 0:U172 3.9 32.3 1.0 O 0:HOH9337 4.0 33.3 1.0 N3 0:U172 4.1 32.5 1.0 C4 0:U163 4.2 29.5 1.0 NE M:ARG82 4.2 35.1 1.0 N4 0:C171 4.3 26.9 1.0 CG M:ARG82 4.4 36.1 1.0 O 0:HOH7845 4.4 27.5 1.0 P 0:C162 4.5 24.7 1.0 CB M:ARG82 4.5 35.2 1.0 C5 0:U163 4.7 28.5 1.0 OP2 0:A169 4.7 24.4 1.0 MG 0:MG8041 4.8 21.9 1.0 OP1 0:A169 4.8 23.8 1.0 O6 0:G164 4.8 26.2 1.0 N3 0:C173 4.8 25.2 1.0 OP1 0:C162 4.9 24.0 1.0 N4 0:C173 4.9 27.1 1.0

G.Blaha, G.Gurel, S.J.Schroeder, P.B.Moore, T.A.Steitz. Mutations Outside the Anisomycin-Binding Site Can Make Ribosomes Drug-Resistant. J.Mol.Biol. V. 379 505 2008.
ISSN: ISSN 0022-2836
PubMed: 18455733
DOI: 10.1016/J.JMB.2008.03.075