Potassium in PDB 2yd0: Crystal Structure of the Soluble Domain of Human Endoplasmic Reticulum Aminopeptidase 1 ERAP1

The structure of Crystal Structure of the Soluble Domain of Human Endoplasmic Reticulum Aminopeptidase 1 ERAP1, PDB code: 2yd0 was solved by M.Vollmar, G.Kochan, T.Krojer, E.Ugochukwu, J.R.C.Muniz, J.Raynor, A.Chaikuad, C.Allerston, F.Von Delft, C.Bountra, C.H.Arrowsmith, J.Weigelt, A.Edwards, S.Knapp, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	19.94 / 2.70
Space group	P 6 2 2
Cell size a, b, c (Å), α, β, γ (°)	200.948, 200.948, 114.222, 90.00, 90.00, 120.00
R / Rfree (%)	15.2 / 21.5

The structure of Crystal Structure of the Soluble Domain of Human Endoplasmic Reticulum Aminopeptidase 1 ERAP1 also contains other interesting chemical elements:

Zinc

(Zn)

1 atom

The binding sites of Potassium atom in the Crystal Structure of the Soluble Domain of Human Endoplasmic Reticulum Aminopeptidase 1 ERAP1 (pdb code 2yd0). This binding sites where shown within 5.0 Angstroms radius around Potassium atom.
In total 2 binding sites of Potassium where determined in the Crystal Structure of the Soluble Domain of Human Endoplasmic Reticulum Aminopeptidase 1 ERAP1, PDB code: 2yd0:
Jump to Potassium binding site number: 1; 2;

Potassium binding site 1 out of 2 in the Crystal Structure of the Soluble Domain of Human Endoplasmic Reticulum Aminopeptidase 1 ERAP1


Mono view


Stereo pair view

A full contact list of Potassium with other atoms in the K binding site number 1 of Crystal Structure of the Soluble Domain of Human Endoplasmic Reticulum Aminopeptidase 1 ERAP1 within 5.0Å range: probe atom residue distance (Å) B Occ A:K1947 b:53.0 occ:1.00 OE1 A:GLU431 3.4 29.1 1.0 NE A:ARG906 3.5 19.2 1.0 NH2 A:ARG906 3.7 10.6 1.0 CZ A:ARG906 4.0 20.7 1.0 CB A:GLU431 4.2 7.0 1.0 CG1 A:VAL423 4.3 5.8 1.0 O A:GLN428 4.3 15.3 1.0 SD A:MET432 4.4 14.6 1.0 CD A:ARG906 4.5 18.2 1.0 CD A:GLU431 4.5 12.4 1.0 CD2 A:HIS417 4.7 4.5 1.0 O A:HOH2164 4.8 17.3 1.0 CG A:GLU431 5.0 14.5 1.0

Potassium binding site 2 out of 2 in the Crystal Structure of the Soluble Domain of Human Endoplasmic Reticulum Aminopeptidase 1 ERAP1


Mono view


Stereo pair view

A full contact list of Potassium with other atoms in the K binding site number 2 of Crystal Structure of the Soluble Domain of Human Endoplasmic Reticulum Aminopeptidase 1 ERAP1 within 5.0Å range: probe atom residue distance (Å) B Occ A:K1948 b:27.8 occ:1.00 OD1 A:ASP295 2.6 29.3 1.0 O A:ASP295 2.7 16.2 1.0 OG A:SER298 3.1 9.5 1.0 C A:ASP295 3.6 10.2 1.0 CG A:ASP295 3.8 22.4 1.0 CA A:ASP295 3.8 11.6 1.0 CB A:SER298 4.2 10.1 1.0 CA A:SER298 4.3 9.7 1.0 O A:HOH2122 4.3 13.8 1.0 CB A:ASP295 4.4 12.5 1.0 N A:SER298 4.6 11.3 1.0 O A:GLU294 4.7 12.2 1.0 N A:TYR296 4.8 9.8 1.0 OD2 A:ASP295 4.8 25.5 1.0

G.Kochan, T.Krojer, D.Harvey, R.Fischer, L.Chen, M.Vollmar, F.Von Delft, K.L.Kavanagh, M.A.Brown, P.Bowness, P.Wordsworth, B.M.Kessler, U.Oppermann. Crystal Structures of the Endoplasmic Reticulum Aminopeptidase-1 (ERAP1) Reveal the Molecular Basis For N-Terminal Peptide Trimming. Proc.Natl.Acad.Sci.Usa V. 108 7745 2011.
ISSN: ISSN 0027-8424
PubMed: 21508329
DOI: 10.1073/PNAS.1101262108