Potassium in PDB 2whv: Crystal Structure of Mouse Cadherin-23 EC1-2 (All Cation Binding Sites Occupied By Calcium)

The structure of Crystal Structure of Mouse Cadherin-23 EC1-2 (All Cation Binding Sites Occupied By Calcium), PDB code: 2whv was solved by M.Sotomayor, W.Weihofen, R.Gaudet, D.P.Corey, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	22.25 / 2.36
Space group	H 3 2
Cell size a, b, c (Å), α, β, γ (°)	151.290, 151.290, 136.881, 90.00, 90.00, 120.00
R / Rfree (%)	20 / 22.1

The structure of Crystal Structure of Mouse Cadherin-23 EC1-2 (All Cation Binding Sites Occupied By Calcium) also contains other interesting chemical elements:

Chlorine	(Cl)	1 atom
Calcium	(Ca)	4 atoms

The binding sites of Potassium atom in the Crystal Structure of Mouse Cadherin-23 EC1-2 (All Cation Binding Sites Occupied By Calcium) (pdb code 2whv). This binding sites where shown within 5.0 Angstroms radius around Potassium atom.
In total 4 binding sites of Potassium where determined in the Crystal Structure of Mouse Cadherin-23 EC1-2 (All Cation Binding Sites Occupied By Calcium), PDB code: 2whv:
Jump to Potassium binding site number: 1; 2; 3; 4;

Potassium binding site 1 out of 4 in the Crystal Structure of Mouse Cadherin-23 EC1-2 (All Cation Binding Sites Occupied By Calcium)


Mono view


Stereo pair view

A full contact list of Potassium with other atoms in the K binding site number 1 of Crystal Structure of Mouse Cadherin-23 EC1-2 (All Cation Binding Sites Occupied By Calcium) within 5.0Å range: probe atom residue distance (Å) B Occ A:K501 b:37.8 occ:1.00 O A:HOH2022 2.3 41.8 1.0 O A:HOH2078 2.3 36.5 1.0 O A:HOH2023 2.4 44.5 1.0 O A:HOH2069 2.4 32.0 1.0 O A:HOH2024 2.5 38.3 1.0 O A:VAL47 2.5 26.7 1.0 O A:HOH2068 2.6 27.4 1.0 C A:VAL47 3.8 26.6 1.0 N A:VAL47 4.1 26.0 1.0 CG1 A:VAL47 4.5 23.8 1.0 O A:HOH2106 4.6 38.8 1.0 CA A:VAL47 4.6 25.7 1.0 OG A:SER53 4.6 28.4 1.0 N A:SER48 4.7 27.6 1.0 CA A:SER48 4.7 29.4 1.0 O A:HOH2089 4.7 17.9 1.0 O A:HOH2066 5.0 18.9 1.0

Potassium binding site 2 out of 4 in the Crystal Structure of Mouse Cadherin-23 EC1-2 (All Cation Binding Sites Occupied By Calcium)


Mono view


Stereo pair view

A full contact list of Potassium with other atoms in the K binding site number 2 of Crystal Structure of Mouse Cadherin-23 EC1-2 (All Cation Binding Sites Occupied By Calcium) within 5.0Å range: probe atom residue distance (Å) B Occ A:K502 b:32.5 occ:1.00 O A:HOH2146 2.4 27.1 1.0 O A:HOH2168 2.4 28.1 1.0 O A:HOH2067 2.4 32.9 1.0 OD1 A:ASN133 2.4 32.4 1.0 O A:HOH2158 2.5 18.2 1.0 O A:HOH2149 2.5 43.6 1.0 CG A:ASN133 3.5 31.1 1.0 OH A:TYR147 4.0 25.9 1.0 O A:HOH2150 4.1 19.0 1.0 CB A:ASN133 4.3 29.6 1.0 ND2 A:ASN133 4.4 29.4 1.0 O A:ARG162 4.6 29.4 1.0 O A:HOH2156 4.6 19.0 1.0 CE2 A:TYR147 4.8 27.5 1.0 CA A:ASN133 4.8 29.6 1.0 O A:VAL132 4.8 29.9 1.0 CZ A:TYR147 4.9 25.6 1.0 O A:ALA161 4.9 27.1 1.0 O A:HOH2148 5.0 13.8 1.0

Potassium binding site 3 out of 4 in the Crystal Structure of Mouse Cadherin-23 EC1-2 (All Cation Binding Sites Occupied By Calcium)


Mono view


Stereo pair view

A full contact list of Potassium with other atoms in the K binding site number 3 of Crystal Structure of Mouse Cadherin-23 EC1-2 (All Cation Binding Sites Occupied By Calcium) within 5.0Å range: probe atom residue distance (Å) B Occ A:K503 b:64.0 occ:1.00 O A:HOH2172 2.4 47.4 1.0 O A:HOH2171 2.7 39.9 1.0 OE1 A:GLU121 2.8 35.9 1.0 OD2 A:ASP206 2.9 40.4 1.0 OE2 A:GLU174 3.0 48.0 1.0 OE1 A:GLU208 3.1 44.9 1.0 CD A:GLU121 3.8 33.9 1.0 CD A:GLU208 3.8 44.5 1.0 OE2 A:GLU208 3.9 45.1 1.0 OE2 A:GLU121 4.0 34.0 1.0 CG A:ASP206 4.1 39.4 1.0 CD A:GLU174 4.2 46.6 1.0 OD1 A:ASP206 4.6 40.6 1.0 CB A:TYR173 4.7 43.6 1.0 CG A:GLU174 4.9 44.6 1.0

Potassium binding site 4 out of 4 in the Crystal Structure of Mouse Cadherin-23 EC1-2 (All Cation Binding Sites Occupied By Calcium)


Mono view


Stereo pair view

A full contact list of Potassium with other atoms in the K binding site number 4 of Crystal Structure of Mouse Cadherin-23 EC1-2 (All Cation Binding Sites Occupied By Calcium) within 5.0Å range: probe atom residue distance (Å) B Occ A:K601 b:49.9 occ:1.00 O A:GLY143 2.6 27.4 1.0 O A:HOH2152 2.7 31.5 1.0 O A:HOH2153 2.8 34.2 1.0 O A:ASP136 2.8 27.0 1.0 C A:GLY143 3.7 26.6 1.0 C A:ASP136 4.0 26.5 1.0 O A:HOH2157 4.0 32.4 1.0 CA A:GLY143 4.1 25.7 1.0 N A:ASP136 4.4 26.8 1.0 O A:HOH2155 4.5 40.3 1.0 CA A:ASP136 4.6 26.9 1.0 O A:ASP138 4.6 24.1 1.0 CB A:ASP136 4.7 26.9 1.0 O A:HOH2072 4.8 27.4 1.0 N A:SER144 4.8 27.1 1.0

M.Sotomayor, W.Weihofen, R.Gaudet, D.P.Corey. Structural Determinants of Cadherin-23 Function in Hearing and Deafness. Neuron V. 66 85 2010.
ISSN: ISSN 0896-6273
PubMed: 20399731
DOI: 10.1016/J.NEURON.2010.03.028