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Potassium in PDB 2vqw: Structure of Inhibitor-Free HDAC4 Catalytic Domain (with Gain-of-Function Mutation HIS332TYR)
Enzymatic activity of Structure of Inhibitor-Free HDAC4 Catalytic Domain (with Gain-of-Function Mutation HIS332TYR)
All present enzymatic activity of Structure of Inhibitor-Free HDAC4 Catalytic Domain (with Gain-of-Function Mutation HIS332TYR):
3.5.1.98;
3.5.1.98;
Protein crystallography data
The structure of Structure of Inhibitor-Free HDAC4 Catalytic Domain (with Gain-of-Function Mutation HIS332TYR), PDB code: 2vqw
was solved by
M.J.Bottomley,
P.Lo Surdo,
P.Di Giovine,
A.Cirillo,
R.Scarpelli,
F.Ferrigno,
P.Jones,
P.Neddermann,
R.De Francesco,
C.Steinkuhler,
P.Gallinari,
A.Carfi,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
| Resolution Low / High (Å) | 20.00 / 3.0 |
| Space group | P 65 |
| Cell size a, b, c (Å), α, β, γ (°) | 137.911, 137.911, 69.519, 90.00, 90.00, 120.00 |
| R / Rfree (%) | 23.3 / 26.1 |
Other elements in 2vqw:
The structure of Structure of Inhibitor-Free HDAC4 Catalytic Domain (with Gain-of-Function Mutation HIS332TYR) also contains other interesting chemical elements:
| Zinc | (Zn) | 2 atoms |
Potassium Binding Sites:
The binding sites of Potassium atom in the Structure of Inhibitor-Free HDAC4 Catalytic Domain (with Gain-of-Function Mutation HIS332TYR)
(pdb code 2vqw). This binding sites where shown within
5.0 Angstroms radius around Potassium atom.
In total 2 binding sites of Potassium where determined in the Structure of Inhibitor-Free HDAC4 Catalytic Domain (with Gain-of-Function Mutation HIS332TYR), PDB code: 2vqw:
Jump to Potassium binding site number: 1; 2;
In total 2 binding sites of Potassium where determined in the Structure of Inhibitor-Free HDAC4 Catalytic Domain (with Gain-of-Function Mutation HIS332TYR), PDB code: 2vqw:
Jump to Potassium binding site number: 1; 2;
Potassium binding site 1 out of 2 in 2vqw
Go back to
Potassium Binding Sites List in 2vqw
Potassium binding site 1 out
of 2 in the Structure of Inhibitor-Free HDAC4 Catalytic Domain (with Gain-of-Function Mutation HIS332TYR)
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Potassium with other atoms in the K binding
site number 1 of Structure of Inhibitor-Free HDAC4 Catalytic Domain (with Gain-of-Function Mutation HIS332TYR) within 5.0Å range:
|
Potassium binding site 2 out of 2 in 2vqw
Go back to
Potassium Binding Sites List in 2vqw
Potassium binding site 2 out
of 2 in the Structure of Inhibitor-Free HDAC4 Catalytic Domain (with Gain-of-Function Mutation HIS332TYR)
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Potassium with other atoms in the K binding
site number 2 of Structure of Inhibitor-Free HDAC4 Catalytic Domain (with Gain-of-Function Mutation HIS332TYR) within 5.0Å range:
|
Reference:
M.J.Bottomley,
P.Lo Surdo,
P.Di Giovine,
A.Cirillo,
R.Scarpelli,
F.Ferrigno,
P.Jones,
P.Neddermann,
R.De Francesco,
C.Steinkuhler,
P.Gallinari,
A.Carfi.
Structural and Functional Analysis of the Human HDAC4 Catalytic Domain Reveals A Regulatory Structural Zinc-Binding Domain. J.Biol.Chem. V. 283 26694 2008.
ISSN: ISSN 0021-9258
PubMed: 18614528
DOI: 10.1074/JBC.M803514200
Page generated: Mon Aug 12 07:19:00 2024
ISSN: ISSN 0021-9258
PubMed: 18614528
DOI: 10.1074/JBC.M803514200
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