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Potassium in PDB 2q8i: Pyruvate Dehydrogenase Kinase Isoform 3 in Complex with Antitumor Drug Radicicol

Enzymatic activity of Pyruvate Dehydrogenase Kinase Isoform 3 in Complex with Antitumor Drug Radicicol

All present enzymatic activity of Pyruvate Dehydrogenase Kinase Isoform 3 in Complex with Antitumor Drug Radicicol:
2.3.1.12; 2.7.11.2;

Protein crystallography data

The structure of Pyruvate Dehydrogenase Kinase Isoform 3 in Complex with Antitumor Drug Radicicol, PDB code: 2q8i was solved by M.Kato, J.Li, J.L.Chuang, D.T.Chuang, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 50.00 / 2.60
Space group P 65 2 2
Cell size a, b, c (Å), α, β, γ (°) 120.872, 120.872, 239.637, 90.00, 90.00, 120.00
R / Rfree (%) 20.5 / 23.8

Other elements in 2q8i:

The structure of Pyruvate Dehydrogenase Kinase Isoform 3 in Complex with Antitumor Drug Radicicol also contains other interesting chemical elements:

Chlorine (Cl) 1 atom

Potassium Binding Sites:

The binding sites of Potassium atom in the Pyruvate Dehydrogenase Kinase Isoform 3 in Complex with Antitumor Drug Radicicol (pdb code 2q8i). This binding sites where shown within 5.0 Angstroms radius around Potassium atom.
In total only one binding site of Potassium was determined in the Pyruvate Dehydrogenase Kinase Isoform 3 in Complex with Antitumor Drug Radicicol, PDB code: 2q8i:

Potassium binding site 1 out of 1 in 2q8i

Go back to Potassium Binding Sites List in 2q8i
Potassium binding site 1 out of 1 in the Pyruvate Dehydrogenase Kinase Isoform 3 in Complex with Antitumor Drug Radicicol


Mono view


Stereo pair view

A full contact list of Potassium with other atoms in the K binding site number 1 of Pyruvate Dehydrogenase Kinase Isoform 3 in Complex with Antitumor Drug Radicicol within 5.0Å range:
probe atom residue distance (Å) B Occ
A:K407

b:64.2
occ:1.00
 O A:PHE22 2.6 50.2 1.0
O A:PHE372 2.6 36.1 1.0
O A:SER20 2.7 50.5 1.0
OD1 A:ASN59 2.9 52.0 1.0
C A:PHE22 3.5 49.6 1.0
C A:ARG21 3.6 46.2 1.0
C A:SER20 3.7 49.0 1.0
C A:PHE372 3.7 37.7 1.0
CG A:ASN59 3.7 51.4 1.0
O A:ARG21 3.8 45.7 1.0
CA A:ARG21 3.9 46.5 1.0
ND2 A:ASN59 3.9 49.1 1.0
N A:PHE372 3.9 37.5 1.0
CG1 A:VAL371 3.9 38.9 1.0
N A:PHE22 4.0 46.9 1.0
N A:ARG21 4.2 47.7 1.0
CA A:PHE372 4.2 37.5 1.0
N A:SER23 4.3 50.4 1.0
CA A:SER23 4.3 51.6 1.0
CA A:PHE22 4.4 48.3 1.0
CB A:PHE372 4.4 37.8 1.0
C A:VAL371 4.6 38.2 1.0
CD A:PRO24 4.7 54.4 1.0
CA A:SER20 4.8 49.0 1.0
N A:ASN373 4.8 37.0 1.0
CD2 A:PHE372 4.9 38.0 1.0
CA A:VAL371 5.0 38.8 1.0

Reference:

M.Kato, J.Li, J.L.Chuang, D.T.Chuang. Distinct Structural Mechanisms For Inhibition of Pyruvate Dehydrogenase Kinase Isoforms By AZD7545, Dichloroacetate, and Radicicol. Structure V. 15 992 2007.
ISSN: ISSN 0969-2126
PubMed: 17683942
DOI: 10.1016/J.STR.2007.07.001
Page generated: Mon Aug 12 06:52:57 2024

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