Potassium in PDB 2q8f: Structure of Pyruvate Dehydrogenase Kinase Isoform 1

All present enzymatic activity of Structure of Pyruvate Dehydrogenase Kinase Isoform 1:
2.7.11.2;

The structure of Structure of Pyruvate Dehydrogenase Kinase Isoform 1, PDB code: 2q8f was solved by M.Kato, J.Li, J.L.Chuang, D.T.Chuang, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	48.11 / 2.03
Space group	P 41 21 2
Cell size a, b, c (Å), α, β, γ (°)	98.190, 98.190, 110.403, 90.00, 90.00, 90.00
R / Rfree (%)	19 / 21.2

The binding sites of Potassium atom in the Structure of Pyruvate Dehydrogenase Kinase Isoform 1 (pdb code 2q8f). This binding sites where shown within 5.0 Angstroms radius around Potassium atom.
In total only one binding site of Potassium was determined in the Structure of Pyruvate Dehydrogenase Kinase Isoform 1, PDB code: 2q8f:

Potassium binding site 1 out of 1 in the Structure of Pyruvate Dehydrogenase Kinase Isoform 1


Mono view


Stereo pair view

A full contact list of Potassium with other atoms in the K binding site number 1 of Structure of Pyruvate Dehydrogenase Kinase Isoform 1 within 5.0Å range: probe atom residue distance (Å) B Occ A:K437 b:39.3 occ:1.00 O A:ALA50 2.3 48.6 1.0 O A:TYR403 2.5 38.8 1.0 OD1 A:ASN89 2.7 45.5 1.0 O A:PHE52 2.7 49.9 1.0 O A:HOH510 2.7 42.6 1.0 CG2 A:VAL402 3.4 37.7 1.0 C A:ALA50 3.5 48.9 1.0 C A:PHE52 3.6 49.5 1.0 CG A:ASN89 3.6 46.9 1.0 O A:ARG51 3.6 50.4 1.0 C A:TYR403 3.6 39.5 1.0 C A:ARG51 3.8 50.3 1.0 O A:HOH500 3.8 41.2 1.0 ND2 A:ASN89 3.9 47.3 1.0 N A:TYR403 4.0 40.2 1.0 N A:PHE52 4.2 50.0 1.0 CA A:TYR403 4.2 39.2 1.0 N A:SER53 4.3 49.0 1.0 CA A:ARG51 4.3 50.7 1.0 CA A:SER53 4.3 50.3 1.0 N A:ARG51 4.4 49.1 1.0 CB A:TYR403 4.4 38.7 1.0 CA A:PHE52 4.4 49.1 1.0 CA A:ALA50 4.5 48.5 1.0 O A:HOH483 4.7 38.2 1.0 N A:ASN404 4.7 38.4 1.0 CB A:VAL402 4.8 41.2 1.0 C A:VAL402 4.8 40.7 1.0 CB A:ASN404 4.9 39.7 1.0 CB A:ASN89 5.0 48.2 1.0

M.Kato, J.Li, J.L.Chuang, D.T.Chuang. Distinct Structural Mechanisms For Inhibition of Pyruvate Dehydrogenase Kinase Isoforms By AZD7545, Dichloroacetate, and Radicicol. Structure V. 15 992 2007.
ISSN: ISSN 0969-2126
PubMed: 17683942
DOI: 10.1016/J.STR.2007.07.001