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Potassium in PDB 2nq7: Crystal Structure of Type 1 Human Methionine Aminopeptidase in Complex with 3-(2,2-Dimethylpropionylamino)Pyridine-2-Carboxylic Acid Thiazole-2-Ylamide

Enzymatic activity of Crystal Structure of Type 1 Human Methionine Aminopeptidase in Complex with 3-(2,2-Dimethylpropionylamino)Pyridine-2-Carboxylic Acid Thiazole-2-Ylamide

All present enzymatic activity of Crystal Structure of Type 1 Human Methionine Aminopeptidase in Complex with 3-(2,2-Dimethylpropionylamino)Pyridine-2-Carboxylic Acid Thiazole-2-Ylamide:
3.4.11.18;

Protein crystallography data

The structure of Crystal Structure of Type 1 Human Methionine Aminopeptidase in Complex with 3-(2,2-Dimethylpropionylamino)Pyridine-2-Carboxylic Acid Thiazole-2-Ylamide, PDB code: 2nq7 was solved by A.Addlagatta, B.W.Matthews, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 20.00 / 1.60
Space group P 1 21 1
Cell size a, b, c (Å), α, β, γ (°) 47.317, 77.442, 47.221, 90.00, 92.31, 90.00
R / Rfree (%) 19.5 / 22.7

Other elements in 2nq7:

The structure of Crystal Structure of Type 1 Human Methionine Aminopeptidase in Complex with 3-(2,2-Dimethylpropionylamino)Pyridine-2-Carboxylic Acid Thiazole-2-Ylamide also contains other interesting chemical elements:

Cobalt (Co) 3 atoms

Potassium Binding Sites:

The binding sites of Potassium atom in the Crystal Structure of Type 1 Human Methionine Aminopeptidase in Complex with 3-(2,2-Dimethylpropionylamino)Pyridine-2-Carboxylic Acid Thiazole-2-Ylamide (pdb code 2nq7). This binding sites where shown within 5.0 Angstroms radius around Potassium atom.
In total only one binding site of Potassium was determined in the Crystal Structure of Type 1 Human Methionine Aminopeptidase in Complex with 3-(2,2-Dimethylpropionylamino)Pyridine-2-Carboxylic Acid Thiazole-2-Ylamide, PDB code: 2nq7:

Potassium binding site 1 out of 1 in 2nq7

Go back to Potassium Binding Sites List in 2nq7
Potassium binding site 1 out of 1 in the Crystal Structure of Type 1 Human Methionine Aminopeptidase in Complex with 3-(2,2-Dimethylpropionylamino)Pyridine-2-Carboxylic Acid Thiazole-2-Ylamide


Mono view


Stereo pair view

A full contact list of Potassium with other atoms in the K binding site number 1 of Crystal Structure of Type 1 Human Methionine Aminopeptidase in Complex with 3-(2,2-Dimethylpropionylamino)Pyridine-2-Carboxylic Acid Thiazole-2-Ylamide within 5.0Å range:
probe atom residue distance (Å) B Occ
A:K404

b:19.6
occ:1.00
 O A:SER363 2.6 16.3 1.0
O A:VAL209 2.6 14.0 1.0
O A:HOH552 2.7 18.9 1.0
O A:ASN207 2.8 19.7 1.0
O A:SER205 3.0 13.4 1.0
C A:ASN207 3.7 15.4 1.0
C A:SER363 3.7 15.1 1.0
N A:ASN207 3.7 15.6 1.0
C A:SER205 3.8 9.7 1.0
C A:VAL209 3.8 12.5 1.0
C A:VAL206 3.8 16.7 1.0
CA A:ASN207 4.0 19.0 1.0
O A:VAL206 4.1 17.5 1.0
CB A:SER205 4.2 11.5 1.0
N A:VAL209 4.2 13.9 1.0
N A:VAL206 4.3 14.7 1.0
CA A:VAL206 4.3 17.0 1.0
N A:SER363 4.4 17.0 1.0
CA A:SER363 4.4 16.5 1.0
O A:HOH471 4.5 14.7 1.0
CA A:VAL209 4.5 13.1 1.0
CB A:SER363 4.5 17.7 1.0
N A:ALA364 4.6 14.5 1.0
CA A:SER205 4.6 9.9 1.0
CB A:VAL209 4.7 12.9 1.0
CA A:ALA364 4.7 11.6 1.0
CD1 A:ILE225 4.7 20.9 1.0
CG1 A:ILE225 4.7 16.7 1.0
N A:GLU208 4.8 14.8 1.0
O A:ILE225 4.8 15.1 1.0
N A:ILE210 4.8 12.7 1.0
C A:GLU208 4.9 13.8 1.0
CA A:ILE210 5.0 15.0 1.0
N A:ASN227 5.0 11.9 1.0
O A:ILE210 5.0 12.2 1.0

Reference:

X.Hu, A.Addlagatta, J.Lu, B.W.Matthews, J.O.Liu. Elucidation of the Function of Type 1 Human Methionine Aminopeptidase During Cell Cycle Progression. Proc.Natl.Acad.Sci.Usa V. 103 18148 2006.
ISSN: ISSN 0027-8424
PubMed: 17114291
DOI: 10.1073/PNAS.0608389103
Page generated: Mon Aug 12 06:47:21 2024

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