Potassium in PDB 2jk5: Potassium Channel Kcsa in Complex with Tetrabutylammonium in High K

The structure of Potassium Channel Kcsa in Complex with Tetrabutylammonium in High K, PDB code: 2jk5 was solved by M.J.Lenaeus, P.J.Focia, T.Wagner, A.Gross, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	30.00 / 2.40
Space group	I 4
Cell size a, b, c (Å), α, β, γ (°)	156.145, 156.145, 76.326, 90.00, 90.00, 90.00
R / Rfree (%)	20.2 / 24.9

The structure of Potassium Channel Kcsa in Complex with Tetrabutylammonium in High K also contains other interesting chemical elements:

Cobalt

(Co)

1 atom

The binding sites of Potassium atom in the Potassium Channel Kcsa in Complex with Tetrabutylammonium in High K (pdb code 2jk5). This binding sites where shown within 5.0 Angstroms radius around Potassium atom.
In total 6 binding sites of Potassium where determined in the Potassium Channel Kcsa in Complex with Tetrabutylammonium in High K, PDB code: 2jk5:
Jump to Potassium binding site number: 1; 2; 3; 4; 5; 6;

Potassium binding site 1 out of 6 in the Potassium Channel Kcsa in Complex with Tetrabutylammonium in High K


Mono view


Stereo pair view

A full contact list of Potassium with other atoms in the K binding site number 1 of Potassium Channel Kcsa in Complex with Tetrabutylammonium in High K within 5.0Å range: probe atom residue distance (Å) B Occ C:K1125 b:16.1 occ:0.25 O C:TYR78 3.0 19.1 1.0 K C:K1126 3.3 22.2 0.2 O C:GLY77 3.5 21.8 1.0 C C:TYR78 3.6 20.6 1.0 K C:K1129 3.8 26.8 0.1 N C:GLY79 4.3 20.3 1.0 CA C:TYR78 4.3 20.6 1.0 CA C:GLY79 4.5 20.4 1.0 C C:GLY77 4.5 22.5 1.0 N C:TYR78 4.9 21.4 1.0

Potassium binding site 2 out of 6 in the Potassium Channel Kcsa in Complex with Tetrabutylammonium in High K


Mono view


Stereo pair view

A full contact list of Potassium with other atoms in the K binding site number 2 of Potassium Channel Kcsa in Complex with Tetrabutylammonium in High K within 5.0Å range: probe atom residue distance (Å) B Occ C:K1126 b:22.2 occ:0.25 O C:GLY77 3.2 21.8 1.0 K C:K1127 3.3 27.5 0.2 O C:VAL76 3.3 22.3 1.0 K C:K1125 3.3 16.1 0.2 C C:GLY77 3.9 22.5 1.0 C C:VAL76 4.4 23.3 1.0 CA C:GLY77 4.4 22.3 1.0 N C:TYR78 4.6 21.4 1.0 N C:GLY77 4.9 23.4 1.0 CA C:TYR78 4.9 20.6 1.0

Potassium binding site 3 out of 6 in the Potassium Channel Kcsa in Complex with Tetrabutylammonium in High K


Mono view


Stereo pair view

A full contact list of Potassium with other atoms in the K binding site number 3 of Potassium Channel Kcsa in Complex with Tetrabutylammonium in High K within 5.0Å range: probe atom residue distance (Å) B Occ C:K1127 b:27.5 occ:0.25 O C:THR75 3.1 21.8 1.0 K C:K1126 3.3 22.2 0.2 O C:VAL76 3.3 22.3 1.0 K C:K1128 3.3 18.0 0.2 C C:VAL76 3.9 23.3 1.0 C C:THR75 4.2 22.8 1.0 CA C:VAL76 4.3 22.9 1.0 N C:VAL76 4.8 23.3 1.0 N C:GLY77 4.8 23.4 1.0

Potassium binding site 4 out of 6 in the Potassium Channel Kcsa in Complex with Tetrabutylammonium in High K


Mono view


Stereo pair view

A full contact list of Potassium with other atoms in the K binding site number 4 of Potassium Channel Kcsa in Complex with Tetrabutylammonium in High K within 5.0Å range: probe atom residue distance (Å) B Occ C:K1128 b:18.0 occ:0.25 OG1 C:THR75 3.0 23.6 1.0 O C:THR75 3.3 21.8 1.0 K C:K1127 3.3 27.5 0.2 CB C:THR75 3.9 23.9 1.0 C C:THR75 4.2 22.8 1.0 C41 C:TBA1133 4.3 21.5 0.1 C41 C:TBA1133 4.4 24.4 0.1 C21 C:TBA1133 4.4 21.8 0.1 C21 C:TBA1133 4.4 24.4 0.1 CA C:THR75 4.7 23.0 1.0 O C:THR74 4.8 20.8 1.0

Potassium binding site 5 out of 6 in the Potassium Channel Kcsa in Complex with Tetrabutylammonium in High K


Mono view


Stereo pair view

A full contact list of Potassium with other atoms in the K binding site number 5 of Potassium Channel Kcsa in Complex with Tetrabutylammonium in High K within 5.0Å range: probe atom residue distance (Å) B Occ C:K1129 b:26.8 occ:0.13 O C:HOH2012 2.4 67.6 1.0 K C:K1125 3.8 16.1 0.2 K C:K1130 3.9 63.2 0.1 O C:TYR78 3.9 19.1 1.0 CA C:GLY79 4.6 20.4 1.0 O C:GLY79 4.9 20.2 1.0

Potassium binding site 6 out of 6 in the Potassium Channel Kcsa in Complex with Tetrabutylammonium in High K


Mono view


Stereo pair view

A full contact list of Potassium with other atoms in the K binding site number 6 of Potassium Channel Kcsa in Complex with Tetrabutylammonium in High K within 5.0Å range: probe atom residue distance (Å) B Occ C:K1130 b:63.2 occ:0.12 O C:HOH2012 3.1 67.6 1.0 K C:K1129 3.9 26.8 0.1 O C:HOH2013 4.1 43.1 0.5 O C:HOH2032 4.2 65.8 1.0

M.J.Lenaeus, D.Burdette, T.Wagner, P.J.Focia, A.Gross. Structures of Kcsa in Complex with Symmetrical Quaternary Ammonium Compounds Reveal A Hydrophobic Binding Site. Biochemistry V. 53 5365 2014.
ISSN: ISSN 0006-2960
PubMed: 25093676
DOI: 10.1021/BI500525S