Potassium in PDB 2ih3: Ion Selectivity in A Semi-Synthetic K+ Channel Locked in the Conductive Conformation

The structure of Ion Selectivity in A Semi-Synthetic K+ Channel Locked in the Conductive Conformation, PDB code: 2ih3 was solved by F.I.Valiyaveetil, M.Leonetti, T.W.Muir, R.Mackinnon, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	31.20 / 1.72
Space group	I 4
Cell size a, b, c (Å), α, β, γ (°)	155.724, 155.724, 75.741, 90.00, 90.00, 90.00
R / Rfree (%)	23.3 / 24.2

The binding sites of Potassium atom in the Ion Selectivity in A Semi-Synthetic K+ Channel Locked in the Conductive Conformation (pdb code 2ih3). This binding sites where shown within 5.0 Angstroms radius around Potassium atom.
In total 7 binding sites of Potassium where determined in the Ion Selectivity in A Semi-Synthetic K+ Channel Locked in the Conductive Conformation, PDB code: 2ih3:
Jump to Potassium binding site number: 1; 2; 3; 4; 5; 6; 7;

Potassium binding site 1 out of 7 in the Ion Selectivity in A Semi-Synthetic K+ Channel Locked in the Conductive Conformation


Mono view


Stereo pair view

A full contact list of Potassium with other atoms in the K binding site number 1 of Ion Selectivity in A Semi-Synthetic K+ Channel Locked in the Conductive Conformation within 5.0Å range: probe atom residue distance (Å) B Occ C:K201 b:16.0 occ:0.25 O C:THR75 2.6 12.0 1.0 O C:VAL76 2.8 13.5 1.0 K C:K202 3.2 16.3 0.2 K C:K204 3.5 17.7 0.2 C C:VAL76 3.6 13.4 1.0 C C:THR75 3.8 11.4 1.0 CA C:VAL76 4.1 13.9 1.0 N C:VAL76 4.4 13.7 1.0 N C:DAL77 4.6 14.3 1.0 CA C:DAL77 5.0 14.2 1.0 CA C:THR75 5.0 12.7 1.0

Potassium binding site 2 out of 7 in the Ion Selectivity in A Semi-Synthetic K+ Channel Locked in the Conductive Conformation


Mono view


Stereo pair view

A full contact list of Potassium with other atoms in the K binding site number 2 of Ion Selectivity in A Semi-Synthetic K+ Channel Locked in the Conductive Conformation within 5.0Å range: probe atom residue distance (Å) B Occ C:K202 b:16.3 occ:0.25 O C:DAL77 2.6 12.7 1.0 O C:VAL76 2.8 13.5 1.0 K C:K201 3.2 16.0 0.2 K C:K203 3.4 17.5 0.2 C C:DAL77 3.5 14.9 1.0 C C:VAL76 4.0 13.4 1.0 CA C:DAL77 4.1 14.2 1.0 N C:DAL77 4.5 14.3 1.0 N C:TYR78 4.5 13.1 1.0 CA C:TYR78 4.9 13.2 1.0

Potassium binding site 3 out of 7 in the Ion Selectivity in A Semi-Synthetic K+ Channel Locked in the Conductive Conformation


Mono view


Stereo pair view

A full contact list of Potassium with other atoms in the K binding site number 3 of Ion Selectivity in A Semi-Synthetic K+ Channel Locked in the Conductive Conformation within 5.0Å range: probe atom residue distance (Å) B Occ C:K203 b:17.5 occ:0.25 O C:TYR78 2.8 15.4 1.0 O C:DAL77 2.9 12.7 1.0 K C:K202 3.4 16.3 0.2 C C:TYR78 3.5 14.6 1.0 C C:DAL77 4.2 14.9 1.0 CA C:TYR78 4.2 13.2 1.0 N C:GLY79 4.2 14.5 1.0 K C:K206 4.4 74.3 0.2 CA C:GLY79 4.4 15.1 1.0 N C:TYR78 4.7 13.1 1.0

Potassium binding site 4 out of 7 in the Ion Selectivity in A Semi-Synthetic K+ Channel Locked in the Conductive Conformation


Mono view


Stereo pair view

A full contact list of Potassium with other atoms in the K binding site number 4 of Ion Selectivity in A Semi-Synthetic K+ Channel Locked in the Conductive Conformation within 5.0Å range: probe atom residue distance (Å) B Occ C:K204 b:17.7 occ:0.25 OG1 C:THR75 2.7 16.3 1.0 O C:THR75 3.0 12.0 1.0 CB C:THR75 3.4 15.2 1.0 K C:K201 3.5 16.0 0.2 C C:THR75 3.9 11.4 1.0 CA C:THR75 4.4 12.7 1.0 CG2 C:THR75 4.7 15.7 1.0 N C:VAL76 4.9 13.7 1.0 O C:THR74 4.9 16.1 1.0

Potassium binding site 5 out of 7 in the Ion Selectivity in A Semi-Synthetic K+ Channel Locked in the Conductive Conformation


Mono view


Stereo pair view

A full contact list of Potassium with other atoms in the K binding site number 5 of Ion Selectivity in A Semi-Synthetic K+ Channel Locked in the Conductive Conformation within 5.0Å range: probe atom residue distance (Å) B Occ C:K205 b:61.7 occ:0.25 O C:HOH324 3.1 53.1 1.0 CE2 C:PHE103 3.7 37.9 1.0 CD2 C:PHE103 4.4 36.2 1.0 CZ C:PHE103 4.7 38.3 1.0

Potassium binding site 6 out of 7 in the Ion Selectivity in A Semi-Synthetic K+ Channel Locked in the Conductive Conformation


Mono view


Stereo pair view

A full contact list of Potassium with other atoms in the K binding site number 6 of Ion Selectivity in A Semi-Synthetic K+ Channel Locked in the Conductive Conformation within 5.0Å range: probe atom residue distance (Å) B Occ C:K206 b:74.3 occ:0.25 K C:K207 3.2 61.8 0.2 O C:HOH337 3.2 59.6 1.0 O C:TYR78 4.2 15.4 1.0 K C:K203 4.4 17.5 0.2 CA C:GLY79 4.7 15.1 1.0 O C:GLY79 4.8 16.0 1.0

Potassium binding site 7 out of 7 in the Ion Selectivity in A Semi-Synthetic K+ Channel Locked in the Conductive Conformation


Mono view


Stereo pair view

A full contact list of Potassium with other atoms in the K binding site number 7 of Ion Selectivity in A Semi-Synthetic K+ Channel Locked in the Conductive Conformation within 5.0Å range: probe atom residue distance (Å) B Occ C:K207 b:61.8 occ:0.25 O C:HOH337 3.2 59.6 1.0 K C:K206 3.2 74.3 0.2 O C:HOH336 3.2 52.7 1.0

F.I.Valiyaveetil, M.Leonetti, T.W.Muir, R.Mackinnon. Ion Selectivity in A Semisynthetic K+ Channel Locked in the Conductive Conformation. Science V. 314 1004 2006.
ISSN: ISSN 0036-8075
PubMed: 17095703
DOI: 10.1126/SCIENCE.1133415