Potassium in PDB 2ih1: Ion Selectivity in A Semi-Synthetic K+ Channel Locked in the Conductive Conformation

The structure of Ion Selectivity in A Semi-Synthetic K+ Channel Locked in the Conductive Conformation, PDB code: 2ih1 was solved by F.I.Valiyaveetil, M.Leonetti, T.W.Muir, R.Mackinnon, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	31.23 / 2.40
Space group	I 4
Cell size a, b, c (Å), α, β, γ (°)	156.391, 156.391, 75.671, 90.00, 90.00, 90.00
R / Rfree (%)	23.3 / 25.1

The binding sites of Potassium atom in the Ion Selectivity in A Semi-Synthetic K+ Channel Locked in the Conductive Conformation (pdb code 2ih1). This binding sites where shown within 5.0 Angstroms radius around Potassium atom.
In total 5 binding sites of Potassium where determined in the Ion Selectivity in A Semi-Synthetic K+ Channel Locked in the Conductive Conformation, PDB code: 2ih1:
Jump to Potassium binding site number: 1; 2; 3; 4; 5;

Potassium binding site 1 out of 5 in the Ion Selectivity in A Semi-Synthetic K+ Channel Locked in the Conductive Conformation


Mono view


Stereo pair view

A full contact list of Potassium with other atoms in the K binding site number 1 of Ion Selectivity in A Semi-Synthetic K+ Channel Locked in the Conductive Conformation within 5.0Å range: probe atom residue distance (Å) B Occ C:K201 b:37.3 occ:0.25 O C:THR75 2.7 27.9 1.0 O C:VAL76 3.2 32.6 1.0 K C:K203 3.5 78.4 0.2 K C:K207 3.6 63.6 0.2 C C:VAL76 3.7 33.8 1.0 C C:THR75 3.9 29.6 1.0 CA C:VAL76 4.1 31.5 1.0 N C:VAL76 4.4 30.3 1.0 N C:DAL77 4.6 35.1 1.0 O C:DAL77 5.0 34.4 1.0

Potassium binding site 2 out of 5 in the Ion Selectivity in A Semi-Synthetic K+ Channel Locked in the Conductive Conformation


Mono view


Stereo pair view

A full contact list of Potassium with other atoms in the K binding site number 2 of Ion Selectivity in A Semi-Synthetic K+ Channel Locked in the Conductive Conformation within 5.0Å range: probe atom residue distance (Å) B Occ C:K202 b:53.8 occ:0.25 O C:TYR78 3.1 28.4 1.0 K C:K207 3.4 63.6 0.2 O C:DAL77 3.5 34.4 1.0 K C:K229 3.6 97.4 0.2 C C:TYR78 3.6 30.1 1.0 N C:GLY79 4.2 27.7 1.0 CA C:GLY79 4.3 28.9 1.0 CA C:TYR78 4.4 30.1 1.0 C C:DAL77 4.6 35.6 1.0 N C:TYR78 5.0 32.1 1.0

Potassium binding site 3 out of 5 in the Ion Selectivity in A Semi-Synthetic K+ Channel Locked in the Conductive Conformation


Mono view


Stereo pair view

A full contact list of Potassium with other atoms in the K binding site number 3 of Ion Selectivity in A Semi-Synthetic K+ Channel Locked in the Conductive Conformation within 5.0Å range: probe atom residue distance (Å) B Occ C:K203 b:78.4 occ:0.25 OG1 C:THR75 2.8 31.7 1.0 O C:THR75 3.1 27.9 1.0 CB C:THR75 3.5 30.7 1.0 K C:K201 3.5 37.3 0.2 C C:THR75 3.9 29.6 1.0 CA C:THR75 4.4 29.5 1.0 CG2 C:THR75 4.7 33.3 1.0 O C:THR74 4.9 29.6 1.0 N C:VAL76 4.9 30.3 1.0

Potassium binding site 4 out of 5 in the Ion Selectivity in A Semi-Synthetic K+ Channel Locked in the Conductive Conformation


Mono view


Stereo pair view

A full contact list of Potassium with other atoms in the K binding site number 4 of Ion Selectivity in A Semi-Synthetic K+ Channel Locked in the Conductive Conformation within 5.0Å range: probe atom residue distance (Å) B Occ C:K207 b:63.6 occ:0.25 O C:DAL77 2.6 34.4 1.0 O C:VAL76 3.3 32.6 1.0 K C:K202 3.4 53.8 0.2 K C:K201 3.6 37.3 0.2 C C:DAL77 3.6 35.6 1.0 CA C:DAL77 4.3 34.7 1.0 C C:VAL76 4.3 33.8 1.0 N C:TYR78 4.6 32.1 1.0 N C:DAL77 4.8 35.1 1.0 CA C:TYR78 4.8 30.1 1.0

Potassium binding site 5 out of 5 in the Ion Selectivity in A Semi-Synthetic K+ Channel Locked in the Conductive Conformation


Mono view


Stereo pair view

A full contact list of Potassium with other atoms in the K binding site number 5 of Ion Selectivity in A Semi-Synthetic K+ Channel Locked in the Conductive Conformation within 5.0Å range: probe atom residue distance (Å) B Occ C:K229 b:97.4 occ:0.25 K C:K202 3.6 53.8 0.2 O C:TYR78 4.0 28.4 1.0 O C:HOH310 4.6 65.0 1.0 CA C:GLY79 4.6 28.9 1.0 O C:GLY79 4.9 29.0 1.0

F.I.Valiyaveetil, M.Leonetti, T.W.Muir, R.Mackinnon. Ion Selectivity in A Semisynthetic K+ Channel Locked in the Conductive Conformation. Science V. 314 1004 2006.
ISSN: ISSN 0036-8075
PubMed: 17095703
DOI: 10.1126/SCIENCE.1133415