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Potassium in PDB 2iby: Crystallographic and Kinetic Studies of Human Mitochondrial Acetoacetyl-Coa Thiolase (T2): the Importance of Potassium and Chloride For Its Structure and Function

Enzymatic activity of Crystallographic and Kinetic Studies of Human Mitochondrial Acetoacetyl-Coa Thiolase (T2): the Importance of Potassium and Chloride For Its Structure and Function

All present enzymatic activity of Crystallographic and Kinetic Studies of Human Mitochondrial Acetoacetyl-Coa Thiolase (T2): the Importance of Potassium and Chloride For Its Structure and Function:
2.3.1.9;

Protein crystallography data

The structure of Crystallographic and Kinetic Studies of Human Mitochondrial Acetoacetyl-Coa Thiolase (T2): the Importance of Potassium and Chloride For Its Structure and Function, PDB code: 2iby was solved by A.M.Haapalainen, R.K.Wierenga, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 73.32 / 1.85
Space group P 1 21 1
Cell size a, b, c (Å), α, β, γ (°) 75.349, 106.746, 101.660, 90.00, 103.06, 90.00
R / Rfree (%) 16.4 / 20.3

Other elements in 2iby:

The structure of Crystallographic and Kinetic Studies of Human Mitochondrial Acetoacetyl-Coa Thiolase (T2): the Importance of Potassium and Chloride For Its Structure and Function also contains other interesting chemical elements:

Chlorine (Cl) 4 atoms

Potassium Binding Sites:

The binding sites of Potassium atom in the Crystallographic and Kinetic Studies of Human Mitochondrial Acetoacetyl-Coa Thiolase (T2): the Importance of Potassium and Chloride For Its Structure and Function (pdb code 2iby). This binding sites where shown within 5.0 Angstroms radius around Potassium atom.
In total 4 binding sites of Potassium where determined in the Crystallographic and Kinetic Studies of Human Mitochondrial Acetoacetyl-Coa Thiolase (T2): the Importance of Potassium and Chloride For Its Structure and Function, PDB code: 2iby:
Jump to Potassium binding site number: 1; 2; 3; 4;

Potassium binding site 1 out of 4 in 2iby

Go back to Potassium Binding Sites List in 2iby
Potassium binding site 1 out of 4 in the Crystallographic and Kinetic Studies of Human Mitochondrial Acetoacetyl-Coa Thiolase (T2): the Importance of Potassium and Chloride For Its Structure and Function


Mono view


Stereo pair view

A full contact list of Potassium with other atoms in the K binding site number 1 of Crystallographic and Kinetic Studies of Human Mitochondrial Acetoacetyl-Coa Thiolase (T2): the Importance of Potassium and Chloride For Its Structure and Function within 5.0Å range:
probe atom residue distance (Å) B Occ
A:K3001

b:13.0
occ:1.00
 O A:ALA283 2.7 9.9 1.0
O A:ALA281 2.7 11.6 1.0
OH A:TYR219 2.7 13.4 1.0
O A:VAL381 2.8 11.9 1.0
O A:HOH6143 2.8 18.5 1.0
O A:ALA280 3.0 14.3 1.0
C A:ALA281 3.4 12.4 1.0
CA A:ALA281 3.8 13.8 1.0
CG2 A:THR285 3.8 14.9 1.0
CZ A:TYR219 3.8 13.2 1.0
C A:VAL381 3.9 13.1 1.0
C A:ALA283 3.9 11.7 1.0
CG1 A:VAL381 4.0 12.9 1.0
C A:ALA280 4.1 16.8 1.0
CE2 A:TYR219 4.1 12.9 1.0
O A:HOH6048 4.3 15.8 1.0
O A:HOH6080 4.3 15.8 1.0
N A:ASN282 4.4 8.9 1.0
N A:ALA281 4.4 13.3 1.0
CA A:VAL381 4.4 12.8 1.0
N6A A:COA6001 4.4 29.9 1.0
N A:ALA283 4.5 11.3 1.0
C A:SER284 4.7 11.9 1.0
CA A:SER284 4.8 10.1 1.0
CB A:VAL381 4.8 11.8 1.0
N A:SER284 4.8 12.1 1.0
CA A:ALA283 4.9 11.7 1.0
N A:THR285 4.9 11.7 1.0
C A:ASN282 4.9 10.7 1.0
CA A:ASN282 4.9 10.0 1.0
N A:SER382 5.0 12.5 1.0

Potassium binding site 2 out of 4 in 2iby

Go back to Potassium Binding Sites List in 2iby
Potassium binding site 2 out of 4 in the Crystallographic and Kinetic Studies of Human Mitochondrial Acetoacetyl-Coa Thiolase (T2): the Importance of Potassium and Chloride For Its Structure and Function


Mono view


Stereo pair view

A full contact list of Potassium with other atoms in the K binding site number 2 of Crystallographic and Kinetic Studies of Human Mitochondrial Acetoacetyl-Coa Thiolase (T2): the Importance of Potassium and Chloride For Its Structure and Function within 5.0Å range:
probe atom residue distance (Å) B Occ
B:K3002

b:15.1
occ:1.00
 O B:ALA283 2.7 14.3 1.0
O B:VAL381 2.7 11.9 1.0
O B:ALA281 2.8 13.3 1.0
OH B:TYR219 2.8 13.6 1.0
O B:HOH6051 2.8 15.9 1.0
O B:ALA280 3.0 13.8 1.0
C B:ALA281 3.4 12.1 1.0
CG2 B:THR285 3.7 17.0 1.0
CA B:ALA281 3.8 14.3 1.0
CZ B:TYR219 3.9 14.1 1.0
C B:VAL381 3.9 10.3 1.0
C B:ALA283 3.9 14.2 1.0
CG1 B:VAL381 3.9 15.3 1.0
C B:ALA280 4.0 17.8 1.0
CE2 B:TYR219 4.1 12.9 1.0
O B:HOH6055 4.1 19.2 1.0
O B:HOH6073 4.4 15.7 1.0
N B:ASN282 4.4 13.4 1.0
N B:ALA281 4.4 15.7 1.0
CA B:VAL381 4.4 10.3 1.0
N B:ALA283 4.5 14.4 1.0
N6A B:COA6002 4.5 30.5 1.0
C B:SER284 4.7 14.5 1.0
CA B:SER284 4.8 13.8 1.0
CB B:VAL381 4.8 13.4 1.0
N B:THR285 4.8 14.8 1.0
N B:SER284 4.8 12.8 1.0
CA B:ALA283 4.8 13.9 1.0
C B:ASN282 4.9 14.2 1.0
CA B:ASN282 4.9 12.8 1.0
N B:SER382 5.0 10.7 1.0
O B:SER284 5.0 14.7 1.0
CB B:THR285 5.0 14.2 1.0

Potassium binding site 3 out of 4 in 2iby

Go back to Potassium Binding Sites List in 2iby
Potassium binding site 3 out of 4 in the Crystallographic and Kinetic Studies of Human Mitochondrial Acetoacetyl-Coa Thiolase (T2): the Importance of Potassium and Chloride For Its Structure and Function


Mono view


Stereo pair view

A full contact list of Potassium with other atoms in the K binding site number 3 of Crystallographic and Kinetic Studies of Human Mitochondrial Acetoacetyl-Coa Thiolase (T2): the Importance of Potassium and Chloride For Its Structure and Function within 5.0Å range:
probe atom residue distance (Å) B Occ
C:K3003

b:28.2
occ:1.00
 O C:ALA283 2.7 25.9 1.0
O C:ALA281 2.7 28.6 1.0
O C:HOH6070 2.7 27.2 1.0
O C:VAL381 2.8 29.7 1.0
OH C:TYR219 2.9 27.6 1.0
O C:ALA280 3.0 30.1 1.0
C C:ALA281 3.4 29.3 1.0
CG2 C:THR285 3.7 27.9 1.0
CA C:ALA281 3.8 29.4 1.0
C C:ALA283 3.9 25.9 1.0
C C:VAL381 3.9 28.4 1.0
CZ C:TYR219 4.0 29.2 1.0
C C:ALA280 4.0 30.7 1.0
CG1 C:VAL381 4.1 28.0 1.0
O C:HOH6134 4.2 37.2 1.0
CE2 C:TYR219 4.2 28.4 1.0
O C:HOH6082 4.2 30.3 1.0
N C:ALA283 4.3 28.3 1.0
N C:ALA281 4.4 29.7 1.0
N C:ASN282 4.4 29.3 1.0
CA C:VAL381 4.5 28.1 1.0
N6A C:COA6003 4.6 49.1 1.0
C C:SER284 4.7 21.5 1.0
CA C:ALA283 4.8 27.0 1.0
CA C:SER284 4.8 22.6 1.0
N C:SER284 4.8 24.3 1.0
N C:THR285 4.9 24.3 1.0
C C:ASN282 4.9 29.6 1.0
O C:SER284 4.9 20.9 1.0
CA C:ASN282 4.9 29.9 1.0
CB C:VAL381 4.9 26.6 1.0

Potassium binding site 4 out of 4 in 2iby

Go back to Potassium Binding Sites List in 2iby
Potassium binding site 4 out of 4 in the Crystallographic and Kinetic Studies of Human Mitochondrial Acetoacetyl-Coa Thiolase (T2): the Importance of Potassium and Chloride For Its Structure and Function


Mono view


Stereo pair view

A full contact list of Potassium with other atoms in the K binding site number 4 of Crystallographic and Kinetic Studies of Human Mitochondrial Acetoacetyl-Coa Thiolase (T2): the Importance of Potassium and Chloride For Its Structure and Function within 5.0Å range:
probe atom residue distance (Å) B Occ
D:K3004

b:26.3
occ:1.00
 O D:VAL381 2.7 24.6 1.0
O D:ALA283 2.7 22.5 1.0
O D:HOH6044 2.8 29.6 1.0
OH D:TYR219 2.8 27.4 1.0
O D:ALA281 3.0 29.7 1.0
O D:ALA280 3.0 32.4 1.0
C D:ALA281 3.6 29.4 1.0
C D:VAL381 3.9 24.4 1.0
CG2 D:THR285 3.9 25.7 1.0
CZ D:TYR219 3.9 26.4 1.0
CA D:ALA281 3.9 30.9 1.0
C D:ALA283 4.0 25.1 1.0
CG1 D:VAL381 4.1 24.6 1.0
C D:ALA280 4.1 32.0 1.0
CE2 D:TYR219 4.3 25.6 1.0
O D:HOH6096 4.3 32.7 1.0
O D:HOH6068 4.3 29.2 1.0
CA D:VAL381 4.4 25.3 1.0
N D:ALA283 4.5 28.4 1.0
N D:ASN282 4.5 28.1 1.0
N6A D:COA6004 4.5 59.8 1.0
N D:ALA281 4.5 31.2 1.0
C D:SER284 4.8 25.8 1.0
CA D:SER284 4.8 25.6 1.0
CB D:VAL381 4.8 26.1 1.0
N D:SER284 4.8 23.4 1.0
N D:THR285 4.8 25.6 1.0
CA D:ALA283 4.9 25.3 1.0
N D:SER382 5.0 26.0 1.0

Reference:

A.M.Haapalainen, G.Merilainen, P.L.Pirila, N.Kondo, T.Fukao, R.K.Wierenga. Crystallographic and Kinetic Studies of Human Mitochondrial Acetoacetyl-Coa Thiolase: the Importance of Potassium and Chloride Ions For Its Structure and Function Biochemistry V. 46 4305 2007.
ISSN: ISSN 0006-2960
PubMed: 17371050
DOI: 10.1021/BI6026192
Page generated: Mon Aug 12 06:38:47 2024

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