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Potassium in PDB 2ib9: Crystallographic and Kinetic Studies of Human Mitochondrial Acetoacetyl-Coa Thiolase (T2): the Importance of Potassium and Chloride For Its Structure and Function

Enzymatic activity of Crystallographic and Kinetic Studies of Human Mitochondrial Acetoacetyl-Coa Thiolase (T2): the Importance of Potassium and Chloride For Its Structure and Function

All present enzymatic activity of Crystallographic and Kinetic Studies of Human Mitochondrial Acetoacetyl-Coa Thiolase (T2): the Importance of Potassium and Chloride For Its Structure and Function:
2.3.1.9;

Protein crystallography data

The structure of Crystallographic and Kinetic Studies of Human Mitochondrial Acetoacetyl-Coa Thiolase (T2): the Importance of Potassium and Chloride For Its Structure and Function, PDB code: 2ib9 was solved by A.M.Haapalainen, R.K.Wierenga, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 73.72 / 2.05
Space group P 1 21 1
Cell size a, b, c (Å), α, β, γ (°) 75.749, 107.440, 102.326, 90.00, 103.06, 90.00
R / Rfree (%) 15.6 / 19.9

Other elements in 2ib9:

The structure of Crystallographic and Kinetic Studies of Human Mitochondrial Acetoacetyl-Coa Thiolase (T2): the Importance of Potassium and Chloride For Its Structure and Function also contains other interesting chemical elements:

Chlorine (Cl) 4 atoms

Potassium Binding Sites:

The binding sites of Potassium atom in the Crystallographic and Kinetic Studies of Human Mitochondrial Acetoacetyl-Coa Thiolase (T2): the Importance of Potassium and Chloride For Its Structure and Function (pdb code 2ib9). This binding sites where shown within 5.0 Angstroms radius around Potassium atom.
In total 4 binding sites of Potassium where determined in the Crystallographic and Kinetic Studies of Human Mitochondrial Acetoacetyl-Coa Thiolase (T2): the Importance of Potassium and Chloride For Its Structure and Function, PDB code: 2ib9:
Jump to Potassium binding site number: 1; 2; 3; 4;

Potassium binding site 1 out of 4 in 2ib9

Go back to Potassium Binding Sites List in 2ib9
Potassium binding site 1 out of 4 in the Crystallographic and Kinetic Studies of Human Mitochondrial Acetoacetyl-Coa Thiolase (T2): the Importance of Potassium and Chloride For Its Structure and Function


Mono view


Stereo pair view

A full contact list of Potassium with other atoms in the K binding site number 1 of Crystallographic and Kinetic Studies of Human Mitochondrial Acetoacetyl-Coa Thiolase (T2): the Importance of Potassium and Chloride For Its Structure and Function within 5.0Å range:
probe atom residue distance (Å) B Occ
A:K3001

b:17.7
occ:1.00
 O A:ALA281 2.7 19.5 1.0
O A:ALA283 2.7 15.9 1.0
O A:VAL381 2.8 19.5 1.0
O A:HOH5101 2.8 23.7 1.0
OH A:TYR219 2.8 17.9 1.0
O A:ALA280 3.0 21.7 1.0
C A:ALA281 3.4 20.6 1.0
CA A:ALA281 3.7 18.6 1.0
CG2 A:THR285 3.8 21.1 1.0
CZ A:TYR219 3.9 17.1 1.0
C A:VAL381 3.9 19.4 1.0
C A:ALA283 4.0 17.5 1.0
C A:ALA280 4.0 22.5 1.0
CG1 A:VAL381 4.1 17.4 1.0
CE2 A:TYR219 4.1 19.8 1.0
O A:HOH5044 4.3 18.0 1.0
N A:ALA281 4.4 20.7 1.0
O A:HOH5037 4.4 14.9 1.0
N A:ASN282 4.5 16.9 1.0
CA A:VAL381 4.5 17.4 1.0
N A:ALA283 4.5 17.3 1.0
C A:SER284 4.7 19.6 1.0
CA A:SER284 4.8 18.4 1.0
N A:SER284 4.8 17.4 1.0
CB A:VAL381 4.9 17.4 1.0
CA A:ALA283 4.9 17.7 1.0
C A:ASN282 4.9 18.2 1.0
O A:HOH5215 4.9 30.3 1.0
N A:THR285 5.0 18.9 1.0
CA A:ASN282 5.0 18.7 1.0
CB A:ALA281 5.0 19.6 1.0
N A:SER382 5.0 19.4 1.0

Potassium binding site 2 out of 4 in 2ib9

Go back to Potassium Binding Sites List in 2ib9
Potassium binding site 2 out of 4 in the Crystallographic and Kinetic Studies of Human Mitochondrial Acetoacetyl-Coa Thiolase (T2): the Importance of Potassium and Chloride For Its Structure and Function


Mono view


Stereo pair view

A full contact list of Potassium with other atoms in the K binding site number 2 of Crystallographic and Kinetic Studies of Human Mitochondrial Acetoacetyl-Coa Thiolase (T2): the Importance of Potassium and Chloride For Its Structure and Function within 5.0Å range:
probe atom residue distance (Å) B Occ
B:K3002

b:21.5
occ:1.00
 O B:ALA283 2.7 24.3 1.0
O B:VAL381 2.8 24.6 1.0
O B:ALA281 2.8 22.4 1.0
OH B:TYR219 2.8 21.1 1.0
O B:HOH5071 2.8 24.4 1.0
O B:ALA280 3.1 26.5 1.0
C B:ALA281 3.5 23.1 1.0
CG2 B:THR285 3.8 26.0 1.0
CA B:ALA281 3.8 23.4 1.0
CZ B:TYR219 3.9 21.6 1.0
C B:VAL381 3.9 20.5 1.0
C B:ALA283 3.9 24.4 1.0
CG1 B:VAL381 4.0 21.5 1.0
C B:ALA280 4.1 27.0 1.0
CE2 B:TYR219 4.1 19.8 1.0
O B:HOH5050 4.3 21.4 1.0
O B:HOH5042 4.3 24.7 1.0
N B:ALA281 4.5 26.4 1.0
CA B:VAL381 4.5 20.9 1.0
N B:ASN282 4.5 23.3 1.0
N B:ALA283 4.6 22.0 1.0
C B:SER284 4.7 23.1 1.0
CA B:SER284 4.8 23.8 1.0
N B:SER284 4.8 24.0 1.0
CB B:VAL381 4.9 21.9 1.0
O B:HOH5198 4.9 35.1 1.0
CA B:ALA283 4.9 23.7 1.0
N B:THR285 4.9 23.0 1.0
CB B:ALA281 5.0 22.4 1.0

Potassium binding site 3 out of 4 in 2ib9

Go back to Potassium Binding Sites List in 2ib9
Potassium binding site 3 out of 4 in the Crystallographic and Kinetic Studies of Human Mitochondrial Acetoacetyl-Coa Thiolase (T2): the Importance of Potassium and Chloride For Its Structure and Function


Mono view


Stereo pair view

A full contact list of Potassium with other atoms in the K binding site number 3 of Crystallographic and Kinetic Studies of Human Mitochondrial Acetoacetyl-Coa Thiolase (T2): the Importance of Potassium and Chloride For Its Structure and Function within 5.0Å range:
probe atom residue distance (Å) B Occ
C:K3003

b:27.5
occ:1.00
 O C:HOH5050 2.7 28.0 1.0
O C:ALA283 2.7 28.1 1.0
O C:ALA281 2.8 27.1 1.0
OH C:TYR219 2.8 27.7 1.0
O C:VAL381 2.8 29.0 1.0
O C:ALA280 3.0 30.1 1.0
C C:ALA281 3.4 28.8 1.0
CA C:ALA281 3.8 29.3 1.0
CG2 C:THR285 3.8 30.0 1.0
CZ C:TYR219 3.9 28.1 1.0
C C:ALA283 4.0 27.9 1.0
O C:HOH5054 4.0 27.9 1.0
C C:VAL381 4.0 28.2 1.0
C C:ALA280 4.1 30.9 1.0
CE2 C:TYR219 4.2 28.9 1.0
CG1 C:VAL381 4.2 27.6 1.0
N C:ALA281 4.4 30.9 1.0
O C:HOH5009 4.5 26.0 1.0
N C:ASN282 4.5 27.1 1.0
N C:ALA283 4.5 27.0 1.0
CA C:VAL381 4.6 26.9 1.0
CA C:SER284 4.8 26.5 1.0
C C:SER284 4.8 26.2 1.0
N C:SER284 4.8 27.7 1.0
CA C:ALA283 4.9 28.5 1.0
C C:ASN282 5.0 27.5 1.0
N C:THR285 5.0 27.3 1.0
CB C:VAL381 5.0 26.9 1.0

Potassium binding site 4 out of 4 in 2ib9

Go back to Potassium Binding Sites List in 2ib9
Potassium binding site 4 out of 4 in the Crystallographic and Kinetic Studies of Human Mitochondrial Acetoacetyl-Coa Thiolase (T2): the Importance of Potassium and Chloride For Its Structure and Function


Mono view


Stereo pair view

A full contact list of Potassium with other atoms in the K binding site number 4 of Crystallographic and Kinetic Studies of Human Mitochondrial Acetoacetyl-Coa Thiolase (T2): the Importance of Potassium and Chloride For Its Structure and Function within 5.0Å range:
probe atom residue distance (Å) B Occ
D:K3004

b:36.4
occ:1.00
 O D:VAL381 2.8 35.0 1.0
O D:ALA283 2.8 34.8 1.0
OH D:TYR219 2.9 36.6 1.0
O D:HOH5042 2.9 29.9 1.0
O D:ALA281 3.0 41.2 1.0
O D:ALA280 3.0 44.8 1.0
C D:ALA281 3.6 41.5 1.0
CG2 D:THR285 3.8 34.9 1.0
C D:VAL381 3.9 35.5 1.0
CZ D:TYR219 4.0 35.7 1.0
CA D:ALA281 4.0 42.6 1.0
C D:ALA283 4.0 36.0 1.0
CG1 D:VAL381 4.1 36.2 1.0
C D:ALA280 4.1 44.1 1.0
O D:HOH5064 4.3 39.1 1.0
CE2 D:TYR219 4.4 36.1 1.0
CA D:VAL381 4.5 36.6 1.0
O D:HOH5066 4.5 32.3 1.0
N D:ALA283 4.5 38.7 1.0
N D:ASN282 4.5 39.2 1.0
N D:ALA281 4.6 43.0 1.0
CA D:SER284 4.8 34.9 1.0
C D:SER284 4.8 33.7 1.0
CB D:VAL381 4.8 37.7 1.0
N D:SER284 4.9 35.1 1.0
N D:THR285 4.9 34.4 1.0
CA D:ALA283 4.9 36.1 1.0
N D:SER382 5.0 35.1 1.0

Reference:

A.M.Haapalainen, G.Merilainen, P.L.Pirila, N.Kondo, T.Fukao, R.K.Wierenga. Crystallographic and Kinetic Studies of Human Mitochondrial Acetoacetyl-Coa Thiolase: the Importance of Potassium and Chloride Ions For Its Structure and Function Biochemistry V. 46 4305 2007.
ISSN: ISSN 0006-2960
PubMed: 17371050
DOI: 10.1021/BI6026192
Page generated: Sat Aug 9 03:36:48 2025

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