Potassium in PDB 2hri: A Parallel Stranded Human Telomeric Quadruplex in Complex with the Porphyrin TMPYP4

The structure of A Parallel Stranded Human Telomeric Quadruplex in Complex with the Porphyrin TMPYP4, PDB code: 2hri was solved by G.N.Parkinson, R.Ghosh, S.Neidle, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	28.35 / 2.09
Space group	C 2 2 21
Cell size a, b, c (Å), α, β, γ (°)	37.290, 61.990, 61.400, 90.00, 90.00, 90.00
R / Rfree (%)	19.8 / 24.8

The binding sites of Potassium atom in the A Parallel Stranded Human Telomeric Quadruplex in Complex with the Porphyrin TMPYP4 (pdb code 2hri). This binding sites where shown within 5.0 Angstroms radius around Potassium atom.
In total 3 binding sites of Potassium where determined in the A Parallel Stranded Human Telomeric Quadruplex in Complex with the Porphyrin TMPYP4, PDB code: 2hri:
Jump to Potassium binding site number: 1; 2; 3;

Potassium binding site 1 out of 3 in the A Parallel Stranded Human Telomeric Quadruplex in Complex with the Porphyrin TMPYP4


Mono view


Stereo pair view

A full contact list of Potassium with other atoms in the K binding site number 1 of A Parallel Stranded Human Telomeric Quadruplex in Complex with the Porphyrin TMPYP4 within 5.0Å range: probe atom residue distance (Å) B Occ A:K23 b:20.4 occ:1.00 O6 B:DG15 2.8 21.4 1.0 O6 A:DG10 2.8 17.6 1.0 O6 B:DG16 2.8 17.5 1.0 O6 B:DG21 2.8 21.5 1.0 O6 B:DG22 2.8 18.7 1.0 O6 A:DG4 2.9 17.6 1.0 O6 A:DG5 2.9 16.9 1.0 O6 A:DG11 2.9 18.8 1.0 K A:K24 3.4 21.0 0.5 K A:K25 3.6 21.2 1.0 C6 B:DG15 3.7 17.9 1.0 C6 A:DG10 3.7 13.8 1.0 C6 B:DG16 3.7 17.7 1.0 C6 B:DG21 3.7 20.6 1.0 C6 A:DG4 3.7 14.5 1.0 C6 A:DG5 3.7 15.2 1.0 C6 B:DG22 3.7 18.2 1.0 C6 A:DG11 3.9 15.8 1.0 N1 B:DG16 3.9 17.4 1.0 N1 A:DG10 3.9 12.7 1.0 N1 B:DG21 4.0 17.9 1.0 N1 A:DG5 4.0 14.5 1.0 N1 B:DG15 4.0 15.8 1.0 N1 B:DG22 4.0 16.2 1.0 N1 A:DG4 4.0 12.1 1.0 N1 A:DG11 4.1 15.4 1.0 C5 B:DG15 4.9 17.7 1.0 C5 A:DG10 4.9 14.9 1.0 C5 B:DG16 4.9 15.3 1.0 C5 A:DG4 4.9 14.2 1.0 C5 A:DG5 4.9 15.8 1.0 C5 B:DG21 4.9 19.8 1.0 C5 B:DG22 5.0 17.3 1.0

Potassium binding site 2 out of 3 in the A Parallel Stranded Human Telomeric Quadruplex in Complex with the Porphyrin TMPYP4


Mono view


Stereo pair view

A full contact list of Potassium with other atoms in the K binding site number 2 of A Parallel Stranded Human Telomeric Quadruplex in Complex with the Porphyrin TMPYP4 within 5.0Å range: probe atom residue distance (Å) B Occ A:K24 b:21.0 occ:0.50 O6 A:DG5 2.8 16.9 1.0 O6 B:DG16 2.8 17.5 1.0 O6 B:DG22 2.9 18.7 1.0 O6 A:DG11 2.9 18.8 1.0 K A:K23 3.4 20.4 1.0 C6 B:DG16 3.7 17.7 1.0 C6 B:DG22 3.7 18.2 1.0 C6 A:DG5 3.7 15.2 1.0 C6 A:DG11 3.8 15.8 1.0 N1 B:DG16 3.9 17.4 1.0 N1 B:DG22 4.0 16.2 1.0 N1 A:DG5 4.0 14.5 1.0 N1 A:DG11 4.1 15.4 1.0 C5 B:DG16 4.8 15.3 1.0 C5 B:DG22 4.9 17.3 1.0 C5 A:DG5 4.9 15.8 1.0

Potassium binding site 3 out of 3 in the A Parallel Stranded Human Telomeric Quadruplex in Complex with the Porphyrin TMPYP4


Mono view


Stereo pair view

A full contact list of Potassium with other atoms in the K binding site number 3 of A Parallel Stranded Human Telomeric Quadruplex in Complex with the Porphyrin TMPYP4 within 5.0Å range: probe atom residue distance (Å) B Occ A:K25 b:21.2 occ:1.00 O6 A:DG3 2.6 22.5 1.0 O6 B:DG20 2.7 22.3 1.0 O6 B:DG14 2.7 19.9 1.0 O6 A:DG9 2.7 19.3 1.0 O6 A:DG10 2.9 17.6 1.0 O6 B:DG15 3.0 21.4 1.0 O6 A:DG4 3.0 17.6 1.0 O6 B:DG21 3.1 21.5 1.0 C6 A:DG3 3.5 21.0 1.0 C6 B:DG20 3.5 19.2 1.0 K A:K23 3.6 20.4 1.0 C6 A:DG9 3.6 15.0 1.0 C6 B:DG14 3.7 19.4 1.0 N6 B:DA13 3.7 19.0 1.0 N1 B:DG20 3.7 19.9 1.0 C6 A:DG10 3.7 13.8 1.0 C6 A:DG4 3.8 14.5 1.0 C6 B:DG15 3.8 17.9 1.0 N1 A:DG3 3.8 20.3 1.0 N1 A:DG9 3.9 18.5 1.0 N1 B:DG14 3.9 19.0 1.0 N1 A:DG4 4.0 12.1 1.0 C6 B:DG21 4.0 20.6 1.0 N1 A:DG10 4.0 12.7 1.0 N1 B:DG15 4.1 15.8 1.0 N1 B:DG21 4.2 17.9 1.0 C6 B:DA13 4.5 20.6 1.0 C5 A:DG3 4.7 21.0 1.0 C5 B:DG20 4.8 19.6 1.0 C5 A:DG9 4.8 14.8 1.0 C5 A:DG10 4.9 14.9 1.0 C5 B:DG14 4.9 18.6 1.0 C5 B:DG15 5.0 17.7 1.0

G.N.Parkinson, R.Ghosh, S.Neidle. Structural Basis For Binding of Porphyrin to Human Telomeres. Biochemistry V. 46 2390 2007.
ISSN: ISSN 0006-2960
PubMed: 17274602
DOI: 10.1021/BI062244N