Potassium in PDB 2h8p: Structure of A K Channel with An Amide to Ester Substitution in the Selectivity Filter

The structure of Structure of A K Channel with An Amide to Ester Substitution in the Selectivity Filter, PDB code: 2h8p was solved by F.I.Valiyaveetil, R.Mackinnon, T.W.Muir, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	49.30 / 2.25
Space group	I 4
Cell size a, b, c (Å), α, β, γ (°)	155.884, 155.884, 75.524, 90.00, 90.00, 90.00
R / Rfree (%)	23.3 / 24.2

The binding sites of Potassium atom in the Structure of A K Channel with An Amide to Ester Substitution in the Selectivity Filter (pdb code 2h8p). This binding sites where shown within 5.0 Angstroms radius around Potassium atom.
In total 6 binding sites of Potassium where determined in the Structure of A K Channel with An Amide to Ester Substitution in the Selectivity Filter, PDB code: 2h8p:
Jump to Potassium binding site number: 1; 2; 3; 4; 5; 6;

Potassium binding site 1 out of 6 in the Structure of A K Channel with An Amide to Ester Substitution in the Selectivity Filter


Mono view


Stereo pair view

A full contact list of Potassium with other atoms in the K binding site number 1 of Structure of A K Channel with An Amide to Ester Substitution in the Selectivity Filter within 5.0Å range: probe atom residue distance (Å) B Occ C:K104 b:22.9 occ:0.25 OG1 C:THR75 2.9 28.1 1.0 O C:THR75 3.1 27.9 1.0 K C:K103 3.4 27.4 0.2 CB C:THR75 3.6 25.9 1.0 C C:THR75 3.9 30.4 1.0 CA C:THR75 4.4 28.9 1.0 CG2 C:THR75 4.8 32.0 1.0 N C:VAL76 4.9 27.1 1.0 O C:THR74 4.9 26.9 1.0

Potassium binding site 2 out of 6 in the Structure of A K Channel with An Amide to Ester Substitution in the Selectivity Filter


Mono view


Stereo pair view

A full contact list of Potassium with other atoms in the K binding site number 2 of Structure of A K Channel with An Amide to Ester Substitution in the Selectivity Filter within 5.0Å range: probe atom residue distance (Å) B Occ C:K103 b:27.4 occ:0.25 O C:THR75 2.8 27.9 1.0 O C:VAL76 3.1 21.6 1.0 K C:K104 3.4 22.9 0.2 K C:K102 3.5 28.8 0.2 C C:VAL76 3.7 27.8 1.0 C C:THR75 3.9 30.4 1.0 CA C:VAL76 4.0 26.3 1.0 N C:VAL76 4.5 27.1 1.0 N C:GLY77 4.6 29.9 1.0 CA C:GLY77 5.0 29.5 1.0

Potassium binding site 3 out of 6 in the Structure of A K Channel with An Amide to Ester Substitution in the Selectivity Filter


Mono view


Stereo pair view

A full contact list of Potassium with other atoms in the K binding site number 3 of Structure of A K Channel with An Amide to Ester Substitution in the Selectivity Filter within 5.0Å range: probe atom residue distance (Å) B Occ C:K102 b:28.8 occ:0.25 O C:GLY77 2.9 29.5 1.0 O C:VAL76 3.1 21.6 1.0 K C:K101 3.5 48.0 0.2 K C:K103 3.5 27.4 0.2 C C:GLY77 3.5 30.1 1.0 CA C:GLY77 4.1 29.5 1.0 C C:VAL76 4.2 27.8 1.0 N C:TYR78 4.4 28.3 1.0 CA C:TYR78 4.7 30.3 1.0 N C:GLY77 4.7 29.9 1.0 C C:TYR78 4.9 30.2 1.0

Potassium binding site 4 out of 6 in the Structure of A K Channel with An Amide to Ester Substitution in the Selectivity Filter


Mono view


Stereo pair view

A full contact list of Potassium with other atoms in the K binding site number 4 of Structure of A K Channel with An Amide to Ester Substitution in the Selectivity Filter within 5.0Å range: probe atom residue distance (Å) B Occ C:K101 b:48.0 occ:0.25 O C:TYR78 2.9 28.4 1.0 K C:K106 2.9 71.6 0.2 O C:GLY77 3.4 29.5 1.0 K C:K102 3.5 28.8 0.2 C C:TYR78 3.5 30.2 1.0 CA C:TYR78 4.2 30.3 1.0 O2 C:GOA79 4.2 30.7 1.0 C2 C:GOA79 4.3 32.4 1.0 C C:GLY77 4.5 30.1 1.0 N C:TYR78 4.8 28.3 1.0

Potassium binding site 5 out of 6 in the Structure of A K Channel with An Amide to Ester Substitution in the Selectivity Filter


Mono view


Stereo pair view

A full contact list of Potassium with other atoms in the K binding site number 5 of Structure of A K Channel with An Amide to Ester Substitution in the Selectivity Filter within 5.0Å range: probe atom residue distance (Å) B Occ C:K106 b:71.6 occ:0.25 K C:K101 2.9 48.0 0.2 O C:HOH120 3.0 53.1 1.0 O C:TYR78 3.5 28.4 1.0 C2 C:GOA79 4.5 32.4 1.0 C C:TYR78 4.6 30.2 1.0 C1 C:GOA79 4.9 34.4 1.0 O11 C:GOA79 4.9 34.0 1.0

Potassium binding site 6 out of 6 in the Structure of A K Channel with An Amide to Ester Substitution in the Selectivity Filter


Mono view


Stereo pair view

A full contact list of Potassium with other atoms in the K binding site number 6 of Structure of A K Channel with An Amide to Ester Substitution in the Selectivity Filter within 5.0Å range: probe atom residue distance (Å) B Occ D:K123 b:41.9 occ:0.25 O C:HOH119 3.1 47.9 1.0 O D:HOH208 3.2 54.4 1.0

F.I.Valiyaveetil, M.Sekedat, R.Mackinnon, T.W.Muir. Structural and Functional Consequences of An Amide-to-Ester Substitution in the Selectivity Filter of A Potassium Channel. J.Am.Chem.Soc. V. 128 11591 2006.
ISSN: ISSN 0002-7863
PubMed: 16939283
DOI: 10.1021/JA0631955