Potassium in PDB 2g50: The Location of the Allosteric Amino Acid Binding Site of Muscle Pyruvate Kinase.
Enzymatic activity of The Location of the Allosteric Amino Acid Binding Site of Muscle Pyruvate Kinase.
All present enzymatic activity of The Location of the Allosteric Amino Acid Binding Site of Muscle Pyruvate Kinase.:
2.7.1.40;
Protein crystallography data
The structure of The Location of the Allosteric Amino Acid Binding Site of Muscle Pyruvate Kinase., PDB code: 2g50
was solved by
T.Holyoak,
R.Williams,
A.W.Fenton,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Resolution Low / High (Å)
|
76.47 /
1.65
|
Space group
|
P 1
|
Cell size a, b, c (Å), α, β, γ (°)
|
82.626,
109.014,
144.463,
95.15,
93.45,
112.26
|
R / Rfree (%)
|
14.8 /
17.4
|
Other elements in 2g50:
The structure of The Location of the Allosteric Amino Acid Binding Site of Muscle Pyruvate Kinase. also contains other interesting chemical elements:
Potassium Binding Sites:
The binding sites of Potassium atom in the The Location of the Allosteric Amino Acid Binding Site of Muscle Pyruvate Kinase.
(pdb code 2g50). This binding sites where shown within
5.0 Angstroms radius around Potassium atom.
In total 8 binding sites of Potassium where determined in the
The Location of the Allosteric Amino Acid Binding Site of Muscle Pyruvate Kinase., PDB code: 2g50:
Jump to Potassium binding site number:
1;
2;
3;
4;
5;
6;
7;
8;
Potassium binding site 1 out
of 8 in 2g50
Go back to
Potassium Binding Sites List in 2g50
Potassium binding site 1 out
of 8 in the The Location of the Allosteric Amino Acid Binding Site of Muscle Pyruvate Kinase.
Mono view
Stereo pair view
|
A full contact list of Potassium with other atoms in the K binding
site number 1 of The Location of the Allosteric Amino Acid Binding Site of Muscle Pyruvate Kinase. within 5.0Å range:
probe
|
atom
|
residue
|
distance (Å)
|
B
|
Occ
|
A:K6501
b:14.2
occ:1.00
|
OD1
|
A:ASP112
|
2.7
|
10.6
|
1.0
|
OG
|
A:SER76
|
2.7
|
11.5
|
1.0
|
OD1
|
A:ASN74
|
2.7
|
9.7
|
1.0
|
O
|
A:THR113
|
2.8
|
8.8
|
1.0
|
O
|
A:HOH6776
|
2.8
|
15.2
|
1.0
|
O
|
A:HOH6779
|
2.9
|
13.5
|
1.0
|
CG
|
A:ASP112
|
3.7
|
9.9
|
1.0
|
C
|
A:THR113
|
3.7
|
8.7
|
1.0
|
OG
|
A:SER242
|
3.7
|
9.2
|
1.0
|
CG
|
A:ASN74
|
3.8
|
10.3
|
1.0
|
CB
|
A:SER76
|
3.9
|
10.6
|
1.0
|
O
|
A:ASP112
|
3.9
|
8.4
|
1.0
|
NZ
|
A:LYS269
|
4.0
|
10.5
|
1.0
|
O
|
A:HOH6775
|
4.1
|
39.7
|
1.0
|
N
|
A:SER76
|
4.1
|
9.9
|
1.0
|
NH2
|
A:ARG72
|
4.3
|
13.9
|
1.0
|
CA
|
A:LYS114
|
4.3
|
7.9
|
1.0
|
C
|
A:ASP112
|
4.3
|
8.6
|
1.0
|
ND2
|
A:ASN74
|
4.3
|
14.0
|
1.0
|
O
|
A:HOH6778
|
4.3
|
12.3
|
1.0
|
N
|
A:LYS114
|
4.3
|
8.2
|
1.0
|
OE2
|
A:GLU117
|
4.5
|
11.1
|
1.0
|
OD2
|
A:ASP112
|
4.5
|
11.2
|
1.0
|
CA
|
A:SER76
|
4.5
|
10.4
|
1.0
|
CB
|
A:ASP112
|
4.5
|
8.7
|
1.0
|
O
|
A:LYS114
|
4.5
|
7.8
|
1.0
|
N
|
A:THR113
|
4.6
|
7.9
|
1.0
|
CA
|
A:THR113
|
4.8
|
8.7
|
1.0
|
C
|
A:LYS114
|
4.8
|
7.8
|
1.0
|
N
|
A:PHE75
|
4.8
|
9.1
|
1.0
|
CB
|
A:SER242
|
4.9
|
8.6
|
1.0
|
CB
|
A:ASN74
|
4.9
|
10.5
|
1.0
|
|
Potassium binding site 2 out
of 8 in 2g50
Go back to
Potassium Binding Sites List in 2g50
Potassium binding site 2 out
of 8 in the The Location of the Allosteric Amino Acid Binding Site of Muscle Pyruvate Kinase.
Mono view
Stereo pair view
|
A full contact list of Potassium with other atoms in the K binding
site number 2 of The Location of the Allosteric Amino Acid Binding Site of Muscle Pyruvate Kinase. within 5.0Å range:
probe
|
atom
|
residue
|
distance (Å)
|
B
|
Occ
|
B:K6502
b:18.6
occ:1.00
|
OD1
|
B:ASP112
|
2.7
|
9.1
|
1.0
|
OD1
|
B:ASN74
|
2.8
|
10.4
|
1.0
|
O
|
B:THR113
|
2.8
|
8.1
|
1.0
|
OG
|
B:SER76
|
2.8
|
9.4
|
1.0
|
O
|
B:HOH6931
|
2.9
|
18.5
|
1.0
|
O
|
B:HOH6928
|
2.9
|
19.0
|
1.0
|
OG
|
B:SER242
|
3.7
|
10.2
|
1.0
|
C
|
B:THR113
|
3.7
|
7.7
|
1.0
|
CG
|
B:ASN74
|
3.7
|
10.9
|
1.0
|
CG
|
B:ASP112
|
3.8
|
9.4
|
1.0
|
O
|
B:ASP112
|
3.9
|
8.2
|
1.0
|
CB
|
B:SER76
|
3.9
|
10.4
|
1.0
|
NZ
|
B:LYS269
|
3.9
|
9.3
|
1.0
|
O
|
B:HOH6927
|
4.1
|
33.4
|
1.0
|
N
|
B:SER76
|
4.2
|
10.1
|
1.0
|
ND2
|
B:ASN74
|
4.2
|
14.9
|
1.0
|
CA
|
B:LYS114
|
4.2
|
8.0
|
1.0
|
C
|
B:ASP112
|
4.3
|
8.3
|
1.0
|
N
|
B:LYS114
|
4.3
|
7.8
|
1.0
|
NH2
|
B:ARG72
|
4.3
|
12.2
|
1.0
|
O
|
B:HOH6930
|
4.3
|
18.6
|
1.0
|
OE2
|
B:GLU117
|
4.5
|
14.2
|
1.0
|
CB
|
B:ASP112
|
4.5
|
8.9
|
1.0
|
O
|
B:LYS114
|
4.5
|
8.5
|
1.0
|
CA
|
B:SER76
|
4.5
|
10.6
|
1.0
|
OD2
|
B:ASP112
|
4.6
|
11.3
|
1.0
|
N
|
B:THR113
|
4.6
|
8.4
|
1.0
|
N
|
B:PHE75
|
4.7
|
8.5
|
1.0
|
CA
|
B:THR113
|
4.8
|
7.8
|
1.0
|
C
|
B:LYS114
|
4.8
|
8.5
|
1.0
|
CB
|
B:SER242
|
4.9
|
10.4
|
1.0
|
CB
|
B:ASN74
|
4.9
|
10.2
|
1.0
|
O
|
B:HOH6929
|
4.9
|
21.8
|
1.0
|
|
Potassium binding site 3 out
of 8 in 2g50
Go back to
Potassium Binding Sites List in 2g50
Potassium binding site 3 out
of 8 in the The Location of the Allosteric Amino Acid Binding Site of Muscle Pyruvate Kinase.
Mono view
Stereo pair view
|
A full contact list of Potassium with other atoms in the K binding
site number 3 of The Location of the Allosteric Amino Acid Binding Site of Muscle Pyruvate Kinase. within 5.0Å range:
probe
|
atom
|
residue
|
distance (Å)
|
B
|
Occ
|
C:K6503
b:13.7
occ:1.00
|
OD1
|
C:ASP112
|
2.7
|
10.4
|
1.0
|
OD1
|
C:ASN74
|
2.7
|
11.0
|
1.0
|
O
|
C:THR113
|
2.8
|
8.4
|
1.0
|
O
|
C:HOH6695
|
2.8
|
12.7
|
1.0
|
OG
|
C:SER76
|
2.8
|
10.6
|
1.0
|
O
|
C:HOH6692
|
2.9
|
15.8
|
1.0
|
OG
|
C:SER242
|
3.7
|
9.8
|
1.0
|
C
|
C:THR113
|
3.7
|
7.7
|
1.0
|
CG
|
C:ASP112
|
3.7
|
9.4
|
1.0
|
CG
|
C:ASN74
|
3.8
|
11.2
|
1.0
|
CB
|
C:SER76
|
3.9
|
10.2
|
1.0
|
NZ
|
C:LYS269
|
4.0
|
8.6
|
1.0
|
O
|
C:ASP112
|
4.0
|
7.8
|
1.0
|
N
|
C:SER76
|
4.1
|
9.8
|
1.0
|
CA
|
C:LYS114
|
4.2
|
7.6
|
1.0
|
ND2
|
C:ASN74
|
4.3
|
13.9
|
1.0
|
C
|
C:ASP112
|
4.3
|
7.7
|
1.0
|
N
|
C:LYS114
|
4.3
|
7.4
|
1.0
|
O
|
C:HOH6694
|
4.3
|
15.1
|
1.0
|
NH2
|
C:ARG72
|
4.4
|
12.2
|
1.0
|
OE2
|
C:GLU117
|
4.4
|
13.9
|
1.0
|
O
|
C:HOH6696
|
4.4
|
31.2
|
1.0
|
O
|
C:LYS114
|
4.5
|
8.1
|
1.0
|
CB
|
C:ASP112
|
4.5
|
8.3
|
1.0
|
OD2
|
C:ASP112
|
4.5
|
9.9
|
1.0
|
CA
|
C:SER76
|
4.5
|
9.9
|
1.0
|
N
|
C:THR113
|
4.6
|
7.1
|
1.0
|
N
|
C:PHE75
|
4.7
|
8.2
|
1.0
|
C
|
C:LYS114
|
4.7
|
7.9
|
1.0
|
CA
|
C:THR113
|
4.8
|
7.8
|
1.0
|
CB
|
C:SER242
|
4.8
|
9.1
|
1.0
|
CB
|
C:ASN74
|
4.9
|
10.2
|
1.0
|
O
|
C:HOH6693
|
5.0
|
15.3
|
1.0
|
|
Potassium binding site 4 out
of 8 in 2g50
Go back to
Potassium Binding Sites List in 2g50
Potassium binding site 4 out
of 8 in the The Location of the Allosteric Amino Acid Binding Site of Muscle Pyruvate Kinase.
Mono view
Stereo pair view
|
A full contact list of Potassium with other atoms in the K binding
site number 4 of The Location of the Allosteric Amino Acid Binding Site of Muscle Pyruvate Kinase. within 5.0Å range:
probe
|
atom
|
residue
|
distance (Å)
|
B
|
Occ
|
D:K6504
b:14.8
occ:1.00
|
OD1
|
D:ASP112
|
2.6
|
11.6
|
1.0
|
O
|
D:THR113
|
2.7
|
4.5
|
1.0
|
OG
|
D:SER76
|
2.7
|
8.8
|
1.0
|
OD1
|
D:ASN74
|
2.8
|
9.4
|
1.0
|
O
|
D:HOH7071
|
2.9
|
15.2
|
1.0
|
O
|
D:HOH7072
|
2.9
|
15.5
|
1.0
|
C
|
D:THR113
|
3.7
|
4.9
|
1.0
|
OG
|
D:SER242
|
3.7
|
10.4
|
1.0
|
CG
|
D:ASP112
|
3.7
|
10.5
|
1.0
|
CG
|
D:ASN74
|
3.8
|
10.8
|
1.0
|
CB
|
D:SER76
|
3.9
|
9.4
|
1.0
|
O
|
D:ASP112
|
3.9
|
7.3
|
1.0
|
NZ
|
D:LYS269
|
3.9
|
9.0
|
1.0
|
N
|
D:SER76
|
4.2
|
9.1
|
1.0
|
CA
|
D:LYS114
|
4.2
|
5.4
|
1.0
|
C
|
D:ASP112
|
4.2
|
6.9
|
1.0
|
N
|
D:LYS114
|
4.3
|
4.8
|
1.0
|
O
|
D:HOH7074
|
4.3
|
38.1
|
1.0
|
NH2
|
D:ARG72
|
4.3
|
13.7
|
1.0
|
ND2
|
D:ASN74
|
4.4
|
14.0
|
1.0
|
O
|
D:HOH7070
|
4.4
|
13.8
|
1.0
|
OE2
|
D:GLU117
|
4.4
|
9.9
|
1.0
|
O
|
D:LYS114
|
4.5
|
5.9
|
1.0
|
OD2
|
D:ASP112
|
4.5
|
11.8
|
1.0
|
CB
|
D:ASP112
|
4.5
|
8.1
|
1.0
|
CA
|
D:SER76
|
4.5
|
9.3
|
1.0
|
N
|
D:THR113
|
4.6
|
5.4
|
1.0
|
C
|
D:LYS114
|
4.7
|
5.9
|
1.0
|
CA
|
D:THR113
|
4.7
|
4.9
|
1.0
|
N
|
D:PHE75
|
4.8
|
8.1
|
1.0
|
CB
|
D:SER242
|
4.9
|
9.3
|
1.0
|
CB
|
D:ASN74
|
5.0
|
10.0
|
1.0
|
O
|
D:HOH7073
|
5.0
|
16.5
|
1.0
|
CA
|
D:ASP112
|
5.0
|
7.8
|
1.0
|
|
Potassium binding site 5 out
of 8 in 2g50
Go back to
Potassium Binding Sites List in 2g50
Potassium binding site 5 out
of 8 in the The Location of the Allosteric Amino Acid Binding Site of Muscle Pyruvate Kinase.
Mono view
Stereo pair view
|
A full contact list of Potassium with other atoms in the K binding
site number 5 of The Location of the Allosteric Amino Acid Binding Site of Muscle Pyruvate Kinase. within 5.0Å range:
probe
|
atom
|
residue
|
distance (Å)
|
B
|
Occ
|
E:K6505
b:13.6
occ:1.00
|
OD1
|
E:ASP112
|
2.6
|
10.0
|
1.0
|
O
|
E:THR113
|
2.7
|
5.0
|
1.0
|
OG
|
E:SER76
|
2.8
|
9.0
|
1.0
|
OD1
|
E:ASN74
|
2.8
|
8.8
|
1.0
|
O
|
E:HOH3434
|
2.9
|
12.6
|
1.0
|
O
|
E:HOH3431
|
3.0
|
15.3
|
1.0
|
CG
|
E:ASP112
|
3.7
|
9.6
|
1.0
|
C
|
E:THR113
|
3.7
|
4.5
|
1.0
|
OG
|
E:SER242
|
3.7
|
9.9
|
1.0
|
CG
|
E:ASN74
|
3.8
|
10.4
|
1.0
|
CB
|
E:SER76
|
3.9
|
8.6
|
1.0
|
O
|
E:ASP112
|
3.9
|
6.2
|
1.0
|
NZ
|
E:LYS269
|
3.9
|
8.7
|
1.0
|
N
|
E:SER76
|
4.1
|
8.4
|
1.0
|
C
|
E:ASP112
|
4.2
|
6.3
|
1.0
|
CA
|
E:LYS114
|
4.2
|
5.0
|
1.0
|
NH2
|
E:ARG72
|
4.3
|
12.8
|
1.0
|
O
|
E:HOH3430
|
4.3
|
40.3
|
1.0
|
N
|
E:LYS114
|
4.3
|
4.5
|
1.0
|
ND2
|
E:ASN74
|
4.3
|
12.2
|
1.0
|
O
|
E:HOH3433
|
4.4
|
15.1
|
1.0
|
OD2
|
E:ASP112
|
4.4
|
10.3
|
1.0
|
OE2
|
E:GLU117
|
4.5
|
11.4
|
1.0
|
CB
|
E:ASP112
|
4.5
|
7.3
|
1.0
|
CA
|
E:SER76
|
4.5
|
8.7
|
1.0
|
O
|
E:LYS114
|
4.6
|
5.7
|
1.0
|
N
|
E:THR113
|
4.6
|
4.6
|
1.0
|
CA
|
E:THR113
|
4.7
|
4.5
|
1.0
|
N
|
E:PHE75
|
4.8
|
8.0
|
1.0
|
C
|
E:LYS114
|
4.8
|
5.7
|
1.0
|
CB
|
E:SER242
|
4.9
|
9.2
|
1.0
|
CB
|
E:ASN74
|
4.9
|
9.9
|
1.0
|
CA
|
E:ASP112
|
5.0
|
7.0
|
1.0
|
O
|
E:HOH3432
|
5.0
|
16.6
|
1.0
|
|
Potassium binding site 6 out
of 8 in 2g50
Go back to
Potassium Binding Sites List in 2g50
Potassium binding site 6 out
of 8 in the The Location of the Allosteric Amino Acid Binding Site of Muscle Pyruvate Kinase.
Mono view
Stereo pair view
|
A full contact list of Potassium with other atoms in the K binding
site number 6 of The Location of the Allosteric Amino Acid Binding Site of Muscle Pyruvate Kinase. within 5.0Å range:
probe
|
atom
|
residue
|
distance (Å)
|
B
|
Occ
|
F:K6506
b:13.2
occ:1.00
|
OD1
|
F:ASP112
|
2.6
|
9.8
|
1.0
|
OD1
|
F:ASN74
|
2.7
|
11.9
|
1.0
|
OG
|
F:SER76
|
2.8
|
10.6
|
1.0
|
O
|
F:THR113
|
2.8
|
7.3
|
1.0
|
O
|
F:HOH6824
|
2.8
|
13.2
|
1.0
|
O
|
F:HOH6524
|
3.0
|
14.8
|
1.0
|
OG
|
F:SER242
|
3.7
|
9.8
|
1.0
|
C
|
F:THR113
|
3.7
|
7.8
|
1.0
|
CG
|
F:ASP112
|
3.7
|
8.7
|
1.0
|
CG
|
F:ASN74
|
3.8
|
11.5
|
1.0
|
CB
|
F:SER76
|
3.9
|
9.1
|
1.0
|
O
|
F:ASP112
|
3.9
|
7.5
|
1.0
|
NZ
|
F:LYS269
|
4.0
|
9.8
|
1.0
|
N
|
F:SER76
|
4.1
|
8.3
|
1.0
|
CA
|
F:LYS114
|
4.2
|
7.5
|
1.0
|
ND2
|
F:ASN74
|
4.3
|
14.4
|
1.0
|
C
|
F:ASP112
|
4.3
|
7.8
|
1.0
|
N
|
F:LYS114
|
4.3
|
7.5
|
1.0
|
NH2
|
F:ARG72
|
4.3
|
11.7
|
1.0
|
O
|
F:HOH6823
|
4.3
|
32.0
|
1.0
|
O
|
F:HOH6825
|
4.4
|
13.0
|
1.0
|
O
|
F:LYS114
|
4.5
|
7.9
|
1.0
|
OE2
|
F:GLU117
|
4.5
|
13.0
|
1.0
|
CA
|
F:SER76
|
4.5
|
9.2
|
1.0
|
OD2
|
F:ASP112
|
4.5
|
10.2
|
1.0
|
CB
|
F:ASP112
|
4.6
|
7.8
|
1.0
|
N
|
F:THR113
|
4.6
|
7.2
|
1.0
|
C
|
F:LYS114
|
4.7
|
8.1
|
1.0
|
N
|
F:PHE75
|
4.8
|
7.8
|
1.0
|
CA
|
F:THR113
|
4.8
|
7.8
|
1.0
|
CB
|
F:SER242
|
4.8
|
9.6
|
1.0
|
CB
|
F:ASN74
|
4.9
|
9.4
|
1.0
|
O
|
F:HOH6523
|
5.0
|
15.2
|
1.0
|
|
Potassium binding site 7 out
of 8 in 2g50
Go back to
Potassium Binding Sites List in 2g50
Potassium binding site 7 out
of 8 in the The Location of the Allosteric Amino Acid Binding Site of Muscle Pyruvate Kinase.
Mono view
Stereo pair view
|
A full contact list of Potassium with other atoms in the K binding
site number 7 of The Location of the Allosteric Amino Acid Binding Site of Muscle Pyruvate Kinase. within 5.0Å range:
probe
|
atom
|
residue
|
distance (Å)
|
B
|
Occ
|
G:K6507
b:22.0
occ:1.00
|
OD1
|
G:ASP112
|
2.7
|
10.1
|
1.0
|
O
|
G:THR113
|
2.7
|
8.3
|
1.0
|
OG
|
G:SER76
|
2.8
|
9.9
|
1.0
|
OD1
|
G:ASN74
|
2.8
|
10.6
|
1.0
|
O
|
G:HOH2778
|
2.9
|
22.8
|
1.0
|
O
|
G:HOH2775
|
2.9
|
20.8
|
1.0
|
OG
|
G:SER242
|
3.6
|
11.8
|
1.0
|
C
|
G:THR113
|
3.7
|
8.8
|
1.0
|
CG
|
G:ASN74
|
3.8
|
11.4
|
1.0
|
CG
|
G:ASP112
|
3.8
|
9.7
|
1.0
|
NZ
|
G:LYS269
|
3.9
|
8.4
|
1.0
|
O
|
G:ASP112
|
3.9
|
8.5
|
1.0
|
CB
|
G:SER76
|
3.9
|
11.0
|
1.0
|
N
|
G:SER76
|
4.2
|
10.8
|
1.0
|
ND2
|
G:ASN74
|
4.2
|
12.4
|
1.0
|
CA
|
G:LYS114
|
4.2
|
8.3
|
1.0
|
C
|
G:ASP112
|
4.2
|
8.5
|
1.0
|
O
|
G:HOH2777
|
4.2
|
20.9
|
1.0
|
N
|
G:LYS114
|
4.3
|
8.2
|
1.0
|
O
|
G:LYS114
|
4.4
|
8.8
|
1.0
|
NH2
|
G:ARG72
|
4.4
|
12.2
|
1.0
|
OE2
|
G:GLU117
|
4.5
|
11.4
|
1.0
|
O
|
G:HOH2779
|
4.5
|
35.3
|
1.0
|
N
|
G:THR113
|
4.5
|
8.4
|
1.0
|
CA
|
G:SER76
|
4.5
|
11.0
|
1.0
|
CB
|
G:ASP112
|
4.5
|
8.1
|
1.0
|
OD2
|
G:ASP112
|
4.6
|
10.5
|
1.0
|
C
|
G:LYS114
|
4.7
|
8.9
|
1.0
|
CA
|
G:THR113
|
4.7
|
8.7
|
1.0
|
CB
|
G:SER242
|
4.8
|
11.9
|
1.0
|
N
|
G:PHE75
|
4.8
|
10.3
|
1.0
|
CB
|
G:ASN74
|
4.9
|
10.8
|
1.0
|
O
|
G:HOH2776
|
5.0
|
25.9
|
1.0
|
CA
|
G:ASP112
|
5.0
|
8.7
|
1.0
|
|
Potassium binding site 8 out
of 8 in 2g50
Go back to
Potassium Binding Sites List in 2g50
Potassium binding site 8 out
of 8 in the The Location of the Allosteric Amino Acid Binding Site of Muscle Pyruvate Kinase.
Mono view
Stereo pair view
|
A full contact list of Potassium with other atoms in the K binding
site number 8 of The Location of the Allosteric Amino Acid Binding Site of Muscle Pyruvate Kinase. within 5.0Å range:
probe
|
atom
|
residue
|
distance (Å)
|
B
|
Occ
|
H:K6508
b:14.7
occ:1.00
|
OD1
|
H:ASP112
|
2.7
|
10.6
|
1.0
|
O
|
H:THR113
|
2.7
|
5.7
|
1.0
|
OG
|
H:SER76
|
2.7
|
8.2
|
1.0
|
OD1
|
H:ASN74
|
2.7
|
8.7
|
1.0
|
O
|
H:HOH6672
|
2.9
|
15.5
|
1.0
|
O
|
H:HOH6675
|
2.9
|
12.4
|
1.0
|
CG
|
H:ASP112
|
3.7
|
9.6
|
1.0
|
OG
|
H:SER242
|
3.7
|
8.6
|
1.0
|
C
|
H:THR113
|
3.7
|
5.7
|
1.0
|
CG
|
H:ASN74
|
3.8
|
10.2
|
1.0
|
CB
|
H:SER76
|
3.9
|
8.4
|
1.0
|
O
|
H:ASP112
|
3.9
|
7.4
|
1.0
|
NZ
|
H:LYS269
|
3.9
|
8.5
|
1.0
|
N
|
H:SER76
|
4.1
|
7.8
|
1.0
|
ND2
|
H:ASN74
|
4.2
|
14.0
|
1.0
|
NH2
|
H:ARG72
|
4.3
|
15.0
|
1.0
|
O
|
H:HOH6671
|
4.3
|
35.2
|
1.0
|
CA
|
H:LYS114
|
4.3
|
6.0
|
1.0
|
C
|
H:ASP112
|
4.3
|
6.9
|
1.0
|
O
|
H:HOH6674
|
4.3
|
11.2
|
1.0
|
N
|
H:LYS114
|
4.4
|
5.5
|
1.0
|
OD2
|
H:ASP112
|
4.5
|
11.1
|
1.0
|
OE2
|
H:GLU117
|
4.5
|
11.2
|
1.0
|
CB
|
H:ASP112
|
4.5
|
7.5
|
1.0
|
CA
|
H:SER76
|
4.5
|
7.8
|
1.0
|
O
|
H:LYS114
|
4.5
|
6.8
|
1.0
|
N
|
H:THR113
|
4.6
|
5.4
|
1.0
|
CA
|
H:THR113
|
4.8
|
5.6
|
1.0
|
N
|
H:PHE75
|
4.8
|
7.6
|
1.0
|
C
|
H:LYS114
|
4.8
|
6.5
|
1.0
|
CB
|
H:SER242
|
4.9
|
9.2
|
1.0
|
CB
|
H:ASN74
|
4.9
|
9.1
|
1.0
|
O
|
H:HOH6673
|
4.9
|
15.6
|
1.0
|
|
Reference:
R.Williams,
T.Holyoak,
G.Mcdonald,
C.Gui,
A.W.Fenton.
Differentiating A Ligand'S Chemical Requirements For Allosteric Interactions From Those For Protein Binding. Phenylalanine Inhibition of Pyruvate Kinase. Biochemistry V. 45 5421 2006.
ISSN: ISSN 0006-2960
PubMed: 16634623
DOI: 10.1021/BI0524262
Page generated: Mon Aug 12 06:26:58 2024
|