Potassium in PDB 2c13: 5-Hydroxy-Levulinic Acid Bound to Porphobilinogen Synthase From Pseudomonas Aeruginosa

All present enzymatic activity of 5-Hydroxy-Levulinic Acid Bound to Porphobilinogen Synthase From Pseudomonas Aeruginosa:
4.2.1.24;

The structure of 5-Hydroxy-Levulinic Acid Bound to Porphobilinogen Synthase From Pseudomonas Aeruginosa, PDB code: 2c13 was solved by F.Frere, M.Nentwich, S.Gacond, D.W.Heinz, R.Neier, N.Frankenberg-Dinkel, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	89.80 / 2.15
Space group	P 4 21 2
Cell size a, b, c (Å), α, β, γ (°)	126.314, 126.314, 85.481, 90.00, 90.00, 90.00
R / Rfree (%)	15.2 / 20.4

The structure of 5-Hydroxy-Levulinic Acid Bound to Porphobilinogen Synthase From Pseudomonas Aeruginosa also contains other interesting chemical elements:

Magnesium	(Mg)	2 atoms
Chlorine	(Cl)	2 atoms

The binding sites of Potassium atom in the 5-Hydroxy-Levulinic Acid Bound to Porphobilinogen Synthase From Pseudomonas Aeruginosa (pdb code 2c13). This binding sites where shown within 5.0 Angstroms radius around Potassium atom.
In total 2 binding sites of Potassium where determined in the 5-Hydroxy-Levulinic Acid Bound to Porphobilinogen Synthase From Pseudomonas Aeruginosa, PDB code: 2c13:
Jump to Potassium binding site number: 1; 2;

Potassium binding site 1 out of 2 in the 5-Hydroxy-Levulinic Acid Bound to Porphobilinogen Synthase From Pseudomonas Aeruginosa


Mono view


Stereo pair view

A full contact list of Potassium with other atoms in the K binding site number 1 of 5-Hydroxy-Levulinic Acid Bound to Porphobilinogen Synthase From Pseudomonas Aeruginosa within 5.0Å range: probe atom residue distance (Å) B Occ A:K1339 b:20.0 occ:1.00 O A:ASP319 2.6 15.1 1.0 OD1 A:ASP37 2.7 14.2 1.0 O A:HOH2222 2.9 16.2 1.0 O A:ASP36 3.2 14.6 1.0 C A:ASP319 3.7 14.8 1.0 CG A:ASP37 3.8 16.2 1.0 C A:ASP36 3.8 15.3 1.0 CA A:ASP37 3.9 15.2 1.0 N A:ASP37 4.1 14.7 1.0 CA A:ASP319 4.2 14.3 1.0 O A:HOH2048 4.2 14.8 1.0 CB A:ASP37 4.3 14.4 1.0 O A:HOH2218 4.4 21.9 1.0 CB A:ASP319 4.4 14.7 1.0 CB A:ASP36 4.5 16.9 1.0 N A:GLY320 4.7 14.0 1.0 CA A:ASP36 4.9 16.1 1.0 OD2 A:ASP37 4.9 13.4 1.0 CA A:GLY320 5.0 13.9 1.0

Potassium binding site 2 out of 2 in the 5-Hydroxy-Levulinic Acid Bound to Porphobilinogen Synthase From Pseudomonas Aeruginosa


Mono view


Stereo pair view

A full contact list of Potassium with other atoms in the K binding site number 2 of 5-Hydroxy-Levulinic Acid Bound to Porphobilinogen Synthase From Pseudomonas Aeruginosa within 5.0Å range: probe atom residue distance (Å) B Occ B:K1340 b:23.0 occ:1.00 O B:ASP319 2.6 14.9 1.0 OD1 B:ASP37 2.7 15.6 1.0 O B:ASP36 3.6 16.5 1.0 C B:ASP319 3.6 14.6 1.0 CG B:ASP37 3.8 15.2 1.0 CA B:ASP37 3.9 14.6 1.0 C B:ASP36 3.9 15.2 1.0 N B:ASP37 4.1 15.1 1.0 CA B:ASP319 4.2 14.7 1.0 O B:HOH2047 4.3 15.4 1.0 CB B:ASP37 4.3 14.9 1.0 CB B:ASP319 4.4 14.4 1.0 CB B:ASP36 4.5 15.4 1.0 O B:HOH2220 4.6 26.6 1.0 N B:GLY320 4.7 14.7 1.0 OD2 B:ASP37 4.9 17.3 1.0 CA B:ASP36 4.9 15.5 1.0 CA B:GLY320 4.9 14.7 1.0

F.Frere, M.Nentwich, S.Gacond, D.W.Heinz, R.Neier, N.Frankenberg-Dinkel. Probing the Active Site of Pseudomonas Aeruginosa Porphobilinogen Synthase Using Newly Developed Inhibitors. Biochemistry V. 45 8243 2006.
ISSN: ISSN 0006-2960
PubMed: 16819823
DOI: 10.1021/BI052611F