Potassium in PDB 2a0q: Structure of Thrombin in 400 Mm Potassium Chloride

All present enzymatic activity of Structure of Thrombin in 400 Mm Potassium Chloride:
3.4.21.5;

The structure of Structure of Thrombin in 400 Mm Potassium Chloride, PDB code: 2a0q was solved by M.Papaconstantinou, C.J.Carrell, A.O.Pineda, K.M.Bobofchak, F.S.Mathews, C.S.Flordellis, M.E.Maragoudakis, N.E.Tsopanoglou, E.Di Cera, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	29.40 / 1.90
Space group	P 21 21 21
Cell size a, b, c (Å), α, β, γ (°)	58.510, 69.740, 158.160, 90.00, 90.00, 90.00
R / Rfree (%)	19.5 / 24

The structure of Structure of Thrombin in 400 Mm Potassium Chloride also contains other interesting chemical elements:

Chlorine

(Cl)

1 atom

The binding sites of Potassium atom in the Structure of Thrombin in 400 Mm Potassium Chloride (pdb code 2a0q). This binding sites where shown within 5.0 Angstroms radius around Potassium atom.
In total 2 binding sites of Potassium where determined in the Structure of Thrombin in 400 Mm Potassium Chloride, PDB code: 2a0q:
Jump to Potassium binding site number: 1; 2;

Potassium binding site 1 out of 2 in the Structure of Thrombin in 400 Mm Potassium Chloride


Mono view


Stereo pair view

A full contact list of Potassium with other atoms in the K binding site number 1 of Structure of Thrombin in 400 Mm Potassium Chloride within 5.0Å range: probe atom residue distance (Å) B Occ B:K403 b:35.3 occ:1.00 O B:LYS224 2.5 18.1 1.0 O B:HOH434 2.5 20.1 1.0 O B:ARG221A 2.7 22.3 1.0 O B:HOH510 2.8 34.6 1.0 O B:HOH409 3.0 24.2 1.0 O B:HOH418 3.4 31.1 1.0 O B:TYR184A 3.4 18.1 1.0 C B:ARG221A 3.7 24.1 1.0 C B:LYS224 3.8 22.0 1.0 O B:HOH406 3.8 21.6 1.0 O B:HOH441 4.0 27.7 1.0 N B:ARG221A 4.1 23.9 1.0 N B:LYS224 4.2 21.7 1.0 CE1 B:TYR225 4.3 19.2 1.0 CD1 B:TYR225 4.4 19.5 1.0 N B:GLY223 4.4 22.1 1.0 N B:ASP222 4.5 19.5 1.0 CA B:ARG221A 4.6 25.6 1.0 C B:TYR184A 4.6 17.2 1.0 C B:ASP221 4.6 22.3 1.0 CA B:ASP222 4.6 21.4 1.0 CA B:LYS224 4.6 19.1 1.0 N B:TYR184A 4.7 18.1 1.0 N B:TYR225 4.7 22.6 1.0 C B:ASP222 4.8 21.9 1.0 CA B:TYR225 4.8 22.4 1.0 CA B:ASP221 4.8 22.6 1.0 OD1 B:ASP221 4.9 27.4 1.0

Potassium binding site 2 out of 2 in the Structure of Thrombin in 400 Mm Potassium Chloride


Mono view


Stereo pair view

A full contact list of Potassium with other atoms in the K binding site number 2 of Structure of Thrombin in 400 Mm Potassium Chloride within 5.0Å range: probe atom residue distance (Å) B Occ D:K404 b:33.1 occ:1.00 O D:HOH447 2.5 36.5 1.0 O B:HOH420 2.7 29.0 1.0 O D:HOH472 2.7 27.5 1.0 O D:GLY142 2.9 20.3 1.0 O D:ILE16 2.9 27.7 1.0 O B:ASP221 2.9 20.7 1.0 O B:HOH476 3.0 26.4 1.0 C D:GLY142 3.7 23.4 1.0 O B:HOH487 3.9 41.2 1.0 C B:ASP221 4.0 22.3 1.0 O B:CYS220 4.1 22.3 1.0 C D:ILE16 4.1 29.6 1.0 NH2 B:ARG187 4.2 22.8 1.0 CA D:GLY142 4.2 19.7 1.0 OD2 B:ASP221 4.4 22.9 1.0 CA D:VAL17 4.5 29.0 1.0 O D:TRP141 4.5 26.7 1.0 CB B:ASP221 4.5 19.6 1.0 O D:HOH429 4.5 23.0 1.0 CA B:ARG221A 4.7 25.6 1.0 N D:VAL17 4.7 27.8 1.0 N B:ARG221A 4.8 23.9 1.0 N D:ASN143 4.8 19.9 1.0 CG B:ASP221 4.8 23.6 1.0 CG2 D:VAL17 4.8 34.1 1.0 CZ B:ARG187 4.8 20.4 1.0 O B:HOH522 4.9 56.9 1.0 CA B:ASP221 4.9 22.6 1.0 CG B:ARG221A 4.9 33.0 1.0 NE B:ARG187 4.9 19.2 1.0

M.E.Papaconstantinou, C.J.Carrell, A.O.Pineda, K.M.Bobofchak, F.S.Mathews, C.S.Flordellis, M.E.Maragoudakis, N.E.Tsopanoglou, E.Di Cera. Thrombin Functions Through Its Rgd Sequence in A Non-Canonical Conformation. J.Biol.Chem. V. 280 29393 2005.
ISSN: ISSN 0021-9258
PubMed: 15998637
DOI: 10.1074/JBC.C500248200