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Potassium in PDB 1xl6: Intermediate Gating Structure 2 of the Inwardly Rectifying K+ Channel KIRBAC3.1

Protein crystallography data

The structure of Intermediate Gating Structure 2 of the Inwardly Rectifying K+ Channel KIRBAC3.1, PDB code: 1xl6 was solved by J.M.Gulbis, A.Kuo, B.Smith, D.A.Doyle, A.Edwards, C.Arrowsmith, M.Sundstrom, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 10.00 / 2.85
Space group P 21 21 2
Cell size a, b, c (Å), α, β, γ (°) 105.756, 107.532, 89.654, 90.00, 90.00, 90.00
R / Rfree (%) 27 / 31

Other elements in 1xl6:

The structure of Intermediate Gating Structure 2 of the Inwardly Rectifying K+ Channel KIRBAC3.1 also contains other interesting chemical elements:

Magnesium (Mg) 1 atom

Potassium Binding Sites:

The binding sites of Potassium atom in the Intermediate Gating Structure 2 of the Inwardly Rectifying K+ Channel KIRBAC3.1 (pdb code 1xl6). This binding sites where shown within 5.0 Angstroms radius around Potassium atom.
In total 7 binding sites of Potassium where determined in the Intermediate Gating Structure 2 of the Inwardly Rectifying K+ Channel KIRBAC3.1, PDB code: 1xl6:
Jump to Potassium binding site number: 1; 2; 3; 4; 5; 6; 7;

Potassium binding site 1 out of 7 in 1xl6

Go back to Potassium Binding Sites List in 1xl6
Potassium binding site 1 out of 7 in the Intermediate Gating Structure 2 of the Inwardly Rectifying K+ Channel KIRBAC3.1


Mono view


Stereo pair view

A full contact list of Potassium with other atoms in the K binding site number 1 of Intermediate Gating Structure 2 of the Inwardly Rectifying K+ Channel KIRBAC3.1 within 5.0Å range:

Potassium binding site 2 out of 7 in 1xl6

Go back to Potassium Binding Sites List in 1xl6
Potassium binding site 2 out of 7 in the Intermediate Gating Structure 2 of the Inwardly Rectifying K+ Channel KIRBAC3.1


Mono view


Stereo pair view

A full contact list of Potassium with other atoms in the K binding site number 2 of Intermediate Gating Structure 2 of the Inwardly Rectifying K+ Channel KIRBAC3.1 within 5.0Å range:
probe atom residue distance (Å) B Occ
A:K1001

b:75.1
occ:0.50
 O A:TYR99 4.6 67.9 1.0
K A:K1002 4.6 46.0 0.5
O B:TYR99 4.6 61.0 1.0

Potassium binding site 3 out of 7 in 1xl6

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Potassium binding site 3 out of 7 in the Intermediate Gating Structure 2 of the Inwardly Rectifying K+ Channel KIRBAC3.1


Mono view


Stereo pair view

A full contact list of Potassium with other atoms in the K binding site number 3 of Intermediate Gating Structure 2 of the Inwardly Rectifying K+ Channel KIRBAC3.1 within 5.0Å range:
probe atom residue distance (Å) B Occ
A:K1002

b:46.0
occ:0.50
 O A:HOH2002 0.5 26.6 0.5
O A:TYR99 2.5 67.9 1.0
O B:TYR99 2.6 61.0 1.0
C A:TYR99 3.3 69.2 1.0
K A:K1004 3.3 36.2 0.5
C B:TYR99 3.4 63.4 1.0
O A:GLY98 3.6 60.5 1.0
O B:GLY98 3.6 54.7 1.0
CA A:TYR99 4.1 67.3 1.0
N A:GLY100 4.1 72.4 1.0
N B:GLY100 4.1 67.0 1.0
CA B:TYR99 4.1 61.7 1.0
CA A:GLY100 4.3 76.0 1.0
CA B:GLY100 4.3 71.0 1.0
C A:GLY98 4.6 61.6 1.0
K A:K1001 4.6 75.1 0.5
C B:GLY98 4.6 56.2 1.0
O B:HOH3002 4.7 55.3 0.5
N A:TYR99 4.9 63.8 1.0
N B:TYR99 4.9 58.2 1.0

Potassium binding site 4 out of 7 in 1xl6

Go back to Potassium Binding Sites List in 1xl6
Potassium binding site 4 out of 7 in the Intermediate Gating Structure 2 of the Inwardly Rectifying K+ Channel KIRBAC3.1


Mono view


Stereo pair view

A full contact list of Potassium with other atoms in the K binding site number 4 of Intermediate Gating Structure 2 of the Inwardly Rectifying K+ Channel KIRBAC3.1 within 5.0Å range:
probe atom residue distance (Å) B Occ
A:K1003

b:25.2
occ:0.50
 O A:HOH2003 0.8 62.5 0.5
MG A:MG2001 1.1 57.8 0.5
K A:K1006 2.7 16.0 0.5
O A:THR96 2.9 48.8 1.0
OG1 A:THR96 2.9 48.6 1.0
O B:THR96 3.0 45.5 1.0
OG1 B:THR96 3.1 48.0 1.0
K B:K1005 3.6 63.2 0.5
C B:THR96 3.8 47.0 1.0
CB A:THR96 3.9 48.0 1.0
C A:THR96 3.9 49.7 1.0
CB B:THR96 4.0 45.6 1.0
O B:ALA95 4.4 46.5 1.0
O A:ALA95 4.5 49.0 1.0
CA A:THR96 4.6 49.3 1.0
CA B:THR96 4.6 46.7 1.0
N B:ILE97 4.7 48.4 1.0
CA B:ILE97 4.8 50.5 1.0
N A:ILE97 4.8 51.4 1.0
CA A:ILE97 5.0 54.4 1.0

Potassium binding site 5 out of 7 in 1xl6

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Potassium binding site 5 out of 7 in the Intermediate Gating Structure 2 of the Inwardly Rectifying K+ Channel KIRBAC3.1


Mono view


Stereo pair view

A full contact list of Potassium with other atoms in the K binding site number 5 of Intermediate Gating Structure 2 of the Inwardly Rectifying K+ Channel KIRBAC3.1 within 5.0Å range:
probe atom residue distance (Å) B Occ
A:K1004

b:36.2
occ:0.50
 O B:HOH3002 1.4 55.3 0.5
O A:GLY98 2.6 60.5 1.0
O B:GLY98 2.7 54.7 1.0
O A:HOH2002 2.9 26.6 0.5
O B:ILE97 3.1 52.3 1.0
O A:ILE97 3.1 55.9 1.0
K B:K1005 3.3 63.2 0.5
K A:K1002 3.3 46.0 0.5
C A:GLY98 3.6 61.6 1.0
C B:GLY98 3.6 56.2 1.0
K A:K1006 4.2 16.0 0.5
C B:ILE97 4.3 52.0 1.0
C A:ILE97 4.3 55.8 1.0
N B:TYR99 4.4 58.2 1.0
CA A:GLY98 4.4 60.1 1.0
N A:TYR99 4.4 63.8 1.0
CA B:GLY98 4.4 55.6 1.0
CA A:TYR99 4.5 67.3 1.0
CA B:TYR99 4.5 61.7 1.0
C B:TYR99 4.7 63.4 1.0
C A:TYR99 4.7 69.2 1.0
O B:TYR99 4.7 61.0 1.0
O A:TYR99 4.7 67.9 1.0
N B:GLY98 4.8 53.1 1.0
N A:GLY98 4.9 56.8 1.0

Potassium binding site 6 out of 7 in 1xl6

Go back to Potassium Binding Sites List in 1xl6
Potassium binding site 6 out of 7 in the Intermediate Gating Structure 2 of the Inwardly Rectifying K+ Channel KIRBAC3.1


Mono view


Stereo pair view

A full contact list of Potassium with other atoms in the K binding site number 6 of Intermediate Gating Structure 2 of the Inwardly Rectifying K+ Channel KIRBAC3.1 within 5.0Å range:
probe atom residue distance (Å) B Occ
A:K1006

b:16.0
occ:0.50
 K B:K1005 0.9 63.2 0.5
O A:HOH2003 1.9 62.5 0.5
O B:THR96 2.7 45.5 1.0
O A:THR96 2.7 48.8 1.0
K A:K1003 2.7 25.2 0.5
O B:HOH3002 2.8 55.3 0.5
O B:ILE97 3.0 52.3 1.0
O A:ILE97 3.1 55.9 1.0
C B:ILE97 3.7 52.0 1.0
CA B:ILE97 3.8 50.5 1.0
C B:THR96 3.8 47.0 1.0
C A:ILE97 3.8 55.8 1.0
C A:THR96 3.8 49.7 1.0
MG A:MG2001 3.9 57.8 0.5
CA A:ILE97 3.9 54.4 1.0
K A:K1004 4.2 36.2 0.5
N B:ILE97 4.3 48.4 1.0
N A:ILE97 4.4 51.4 1.0
OG1 A:THR96 4.7 48.6 1.0
OG1 B:THR96 4.9 48.0 1.0
N B:GLY98 4.9 53.1 1.0

Potassium binding site 7 out of 7 in 1xl6

Go back to Potassium Binding Sites List in 1xl6
Potassium binding site 7 out of 7 in the Intermediate Gating Structure 2 of the Inwardly Rectifying K+ Channel KIRBAC3.1


Mono view


Stereo pair view

A full contact list of Potassium with other atoms in the K binding site number 7 of Intermediate Gating Structure 2 of the Inwardly Rectifying K+ Channel KIRBAC3.1 within 5.0Å range:
probe atom residue distance (Å) B Occ
B:K1005

b:63.2
occ:0.50
 K A:K1006 0.9 16.0 0.5
O B:HOH3002 1.9 55.3 0.5
O B:ILE97 2.5 52.3 1.0
O A:ILE97 2.6 55.9 1.0
O A:HOH2003 2.7 62.5 0.5
O B:THR96 3.2 45.5 1.0
O A:THR96 3.2 48.8 1.0
K A:K1004 3.3 36.2 0.5
C B:ILE97 3.4 52.0 1.0
C A:ILE97 3.6 55.8 1.0
K A:K1003 3.6 25.2 0.5
CA B:ILE97 3.8 50.5 1.0
CA A:ILE97 4.0 54.4 1.0
C B:THR96 4.2 47.0 1.0
C A:THR96 4.2 49.7 1.0
N B:ILE97 4.5 48.4 1.0
N A:ILE97 4.6 51.4 1.0
N B:GLY98 4.6 53.1 1.0
N A:GLY98 4.7 56.8 1.0
MG A:MG2001 4.7 57.8 0.5
O A:GLY98 4.8 60.5 1.0
O B:GLY98 4.8 54.7 1.0

Reference:

J.M.Gulbis, A.Kuo, B.Smith, D.A.Doyle, A.Edwards, C.Arrowsmith, M.Sundstrom. Two Intermediate Gating State Crystal Structures of the KIRBAC3.1 K+ Channel To Be Published.
Page generated: Mon Aug 12 05:46:27 2024

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