Potassium in PDB 1x7z: Crystal Structure of the Human Mitochondrial Branched-Chain Alpha- Ketoacid Dehydrogenase

All present enzymatic activity of Crystal Structure of the Human Mitochondrial Branched-Chain Alpha- Ketoacid Dehydrogenase:
1.2.4.4;

The structure of Crystal Structure of the Human Mitochondrial Branched-Chain Alpha- Ketoacid Dehydrogenase, PDB code: 1x7z was solved by R.M.Wynn, M.Kato, M.Machius, J.L.Chuang, J.Li, D.R.Tomchick, D.T.Chuang, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	50.00 / 1.72
Space group	P 31 2 1
Cell size a, b, c (Å), α, β, γ (°)	145.310, 145.310, 69.322, 90.00, 90.00, 120.00
R / Rfree (%)	15.3 / 18.9

The structure of Crystal Structure of the Human Mitochondrial Branched-Chain Alpha- Ketoacid Dehydrogenase also contains other interesting chemical elements:

Manganese	(Mn)	1 atom
Chlorine	(Cl)	1 atom

The binding sites of Potassium atom in the Crystal Structure of the Human Mitochondrial Branched-Chain Alpha- Ketoacid Dehydrogenase (pdb code 1x7z). This binding sites where shown within 5.0 Angstroms radius around Potassium atom.
In total 2 binding sites of Potassium where determined in the Crystal Structure of the Human Mitochondrial Branched-Chain Alpha- Ketoacid Dehydrogenase, PDB code: 1x7z:
Jump to Potassium binding site number: 1; 2;

Potassium binding site 1 out of 2 in the Crystal Structure of the Human Mitochondrial Branched-Chain Alpha- Ketoacid Dehydrogenase


Mono view


Stereo pair view

A full contact list of Potassium with other atoms in the K binding site number 1 of Crystal Structure of the Human Mitochondrial Branched-Chain Alpha- Ketoacid Dehydrogenase within 5.0Å range: probe atom residue distance (Å) B Occ A:K701 b:14.3 occ:1.00 O A:PRO163 2.6 8.8 1.0 O A:HOH802 2.6 12.6 1.0 O A:SER161 2.8 6.5 1.0 OE1 A:GLN167 2.8 7.3 1.0 OG A:SER161 2.9 6.4 1.0 OE1 A:GLN112 3.0 2.0 0.5 OG1 A:THR166 3.0 8.1 1.0 C A:SER161 3.7 7.4 1.0 C A:PRO163 3.8 7.0 1.0 CD A:GLN112 3.8 8.6 0.5 CD A:GLN167 3.9 9.1 1.0 CB A:SER161 4.1 5.9 1.0 N A:SER161 4.1 7.0 1.0 O B:HOH916 4.1 13.8 1.0 CA A:SER161 4.1 6.3 1.0 N A:GLN167 4.2 6.5 1.0 N A:THR166 4.2 7.2 1.0 CB A:THR166 4.4 8.1 1.0 N A:PRO163 4.4 7.8 1.0 CB A:GLN167 4.5 5.2 1.0 CG A:GLN112 4.5 10.6 0.5 O A:HOH812 4.5 14.0 1.0 N A:ALA165 4.5 6.3 1.0 O A:GLY111 4.5 10.8 1.0 O A:HOH810 4.6 13.9 1.0 C A:SER162 4.6 7.9 1.0 CA A:PRO163 4.6 8.1 1.0 CA A:LEU164 4.6 5.7 1.0 NE2 A:GLN112 4.6 11.7 0.5 N A:LEU164 4.7 5.9 1.0 OE2 B:GLU113 4.7 13.3 1.0 N A:SER162 4.7 6.5 1.0 NE2 A:GLN167 4.7 6.7 1.0 C A:LEU164 4.7 5.3 1.0 CG A:GLN167 4.7 5.0 1.0 CD A:PRO163 4.7 7.7 1.0 CA A:THR166 4.8 6.7 1.0 CB A:GLN112 4.8 10.5 0.5 O A:SER162 4.9 8.9 1.0 C A:THR166 4.9 5.9 1.0

Potassium binding site 2 out of 2 in the Crystal Structure of the Human Mitochondrial Branched-Chain Alpha- Ketoacid Dehydrogenase


Mono view


Stereo pair view

A full contact list of Potassium with other atoms in the K binding site number 2 of Crystal Structure of the Human Mitochondrial Branched-Chain Alpha- Ketoacid Dehydrogenase within 5.0Å range: probe atom residue distance (Å) B Occ B:K702 b:15.3 occ:1.00 O B:ASN183 2.7 9.5 1.0 O B:GLY128 2.7 10.9 1.0 O B:CYS178 2.8 8.7 1.0 O B:ASP181 2.8 8.7 1.0 O B:LEU130 2.9 7.9 1.0 O B:HOH915 2.9 13.5 1.0 OG1 B:THR131 3.5 9.3 1.0 C B:ASN183 3.8 9.2 1.0 C B:LEU130 3.8 8.3 1.0 C B:ASP181 3.9 10.1 1.0 C B:GLY128 3.9 10.0 1.0 C B:CYS178 3.9 8.1 1.0 O B:ILE179 4.0 9.6 1.0 SG B:CYS185 4.0 11.7 1.0 O B:HOH1029 4.1 30.2 1.0 N B:ASN183 4.2 8.9 1.0 N B:LEU130 4.2 8.1 1.0 N B:CYS185 4.2 8.3 1.0 C B:SER129 4.3 8.3 1.0 C B:ILE179 4.3 8.5 1.0 CB B:ASP181 4.3 11.8 1.0 N B:ASP181 4.3 10.2 1.0 CB B:CYS185 4.3 9.2 1.0 CA B:SER129 4.4 8.0 1.0 CA B:ASP181 4.4 9.8 1.0 CA B:PRO184 4.5 8.3 1.0 N B:THR131 4.5 8.5 1.0 N B:PRO184 4.6 8.6 1.0 CA B:ILE179 4.6 8.3 1.0 CA B:LEU130 4.6 7.7 1.0 N B:SER129 4.6 7.6 1.0 CA B:ASN183 4.7 8.7 1.0 CB B:THR131 4.7 8.4 1.0 C B:PRO184 4.7 8.6 1.0 N B:ILE179 4.7 8.0 1.0 CA B:THR131 4.8 7.5 1.0 O B:SER129 4.8 8.2 1.0 N B:LYS182 4.9 8.3 1.0 OD2 B:ASP181 4.9 14.1 1.0 CA B:CYS178 4.9 8.5 1.0 CA B:GLY128 4.9 10.0 1.0 CA B:CYS185 5.0 9.5 1.0

R.M.Wynn, M.Kato, M.Machius, J.L.Chuang, J.Li, D.R.Tomchick, D.T.Chuang. Molecular Mechanism For Regulation of the Human Mitochondrial Branched-Chain Alpha-Ketoacid Dehydrogenase Complex By Phosphorylation Structure V. 12 2185 2004.
ISSN: ISSN 0969-2126
PubMed: 15576032
DOI: 10.1016/J.STR.2004.09.013