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Potassium in PDB 1wci: Reactivity Modulation of Human Branched-Chain Alpha-Ketoacid Dehydrogenase By An Internal Molecular Switch

Enzymatic activity of Reactivity Modulation of Human Branched-Chain Alpha-Ketoacid Dehydrogenase By An Internal Molecular Switch

All present enzymatic activity of Reactivity Modulation of Human Branched-Chain Alpha-Ketoacid Dehydrogenase By An Internal Molecular Switch:
1.2.4.4;

Protein crystallography data

The structure of Reactivity Modulation of Human Branched-Chain Alpha-Ketoacid Dehydrogenase By An Internal Molecular Switch, PDB code: 1wci was solved by M.Machius, R.M.Wynn, J.L.Chuang, D.R.Tomchick, C.A.Brautigam, D.T.Chuang, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 30.00 / 1.84
Space group P 31 2 1
Cell size a, b, c (Å), α, β, γ (°) 145.044, 145.044, 69.510, 90.00, 90.00, 120.00
R / Rfree (%) 14.8 / 18.8

Other elements in 1wci:

The structure of Reactivity Modulation of Human Branched-Chain Alpha-Ketoacid Dehydrogenase By An Internal Molecular Switch also contains other interesting chemical elements:

Manganese (Mn) 1 atom
Chlorine (Cl) 2 atoms

Potassium Binding Sites:

The binding sites of Potassium atom in the Reactivity Modulation of Human Branched-Chain Alpha-Ketoacid Dehydrogenase By An Internal Molecular Switch (pdb code 1wci). This binding sites where shown within 5.0 Angstroms radius around Potassium atom.
In total 2 binding sites of Potassium where determined in the Reactivity Modulation of Human Branched-Chain Alpha-Ketoacid Dehydrogenase By An Internal Molecular Switch, PDB code: 1wci:
Jump to Potassium binding site number: 1; 2;

Potassium binding site 1 out of 2 in 1wci

Go back to Potassium Binding Sites List in 1wci
Potassium binding site 1 out of 2 in the Reactivity Modulation of Human Branched-Chain Alpha-Ketoacid Dehydrogenase By An Internal Molecular Switch


Mono view


Stereo pair view

A full contact list of Potassium with other atoms in the K binding site number 1 of Reactivity Modulation of Human Branched-Chain Alpha-Ketoacid Dehydrogenase By An Internal Molecular Switch within 5.0Å range:
probe atom residue distance (Å) B Occ
A:K1402

b:18.3
occ:1.00
O A:PRO163 2.6 12.2 1.0
O A:HOH2110 2.7 9.6 1.0
OE1 A:GLN167 2.8 10.5 1.0
O A:SER161 2.9 10.5 1.0
OG A:SER161 3.0 13.0 1.0
OG1 A:THR166 3.0 12.1 1.0
O A:HOH2112 3.1 14.1 1.0
C A:SER161 3.7 11.6 1.0
C A:PRO163 3.8 11.6 1.0
CD A:GLN167 3.8 12.0 1.0
O B:HOH2107 3.9 13.7 1.0
N A:SER161 4.1 10.0 1.0
CB A:SER161 4.2 11.6 1.0
N A:GLN167 4.2 10.3 1.0
CA A:SER161 4.2 10.5 1.0
N A:THR166 4.3 8.6 1.0
CB A:THR166 4.4 11.8 1.0
O A:HOH2171 4.4 11.7 1.0
N A:PRO163 4.4 10.3 1.0
CB A:GLN167 4.4 11.3 1.0
O A:GLY111 4.5 13.2 1.0
N A:ALA165 4.5 8.9 1.0
O A:HOH2113 4.5 10.7 1.0
C A:SER162 4.6 10.5 1.0
OE2 B:GLU113 4.6 12.4 1.0
CA A:PRO163 4.6 11.3 1.0
CG A:GLN167 4.6 9.2 1.0
NE2 A:GLN167 4.7 10.5 1.0
N A:SER162 4.7 9.9 1.0
CA A:LEU164 4.7 9.7 1.0
CA A:THR166 4.7 11.2 1.0
N A:LEU164 4.7 12.2 1.0
C A:LEU164 4.8 8.4 1.0
CD A:PRO163 4.8 9.1 1.0
O A:SER162 4.9 12.3 1.0
C A:THR166 4.9 10.9 1.0
CA A:GLN167 4.9 11.6 1.0
CB A:PRO163 4.9 12.4 1.0

Potassium binding site 2 out of 2 in 1wci

Go back to Potassium Binding Sites List in 1wci
Potassium binding site 2 out of 2 in the Reactivity Modulation of Human Branched-Chain Alpha-Ketoacid Dehydrogenase By An Internal Molecular Switch


Mono view


Stereo pair view

A full contact list of Potassium with other atoms in the K binding site number 2 of Reactivity Modulation of Human Branched-Chain Alpha-Ketoacid Dehydrogenase By An Internal Molecular Switch within 5.0Å range:
probe atom residue distance (Å) B Occ
B:K1346

b:20.9
occ:1.00
O B:ASN183 2.7 9.9 1.0
O B:GLY128 2.7 10.9 1.0
O B:CYS178 2.8 10.4 1.0
O B:ASP181 2.8 10.7 1.0
O B:LEU130 3.0 7.2 1.0
O B:HOH2122 3.1 13.4 1.0
OG1 B:THR131 3.5 9.1 1.0
C B:ASN183 3.7 9.8 1.0
C B:LEU130 3.8 8.3 1.0
C B:ASP181 3.8 10.5 1.0
C B:GLY128 3.9 10.7 1.0
C B:CYS178 4.0 10.8 1.0
O B:ILE179 4.0 9.7 1.0
SG B:CYS185 4.0 12.4 1.0
N B:ASN183 4.2 10.2 1.0
N B:LEU130 4.2 8.7 1.0
C B:SER129 4.3 7.8 1.0
N B:ASP181 4.3 10.7 1.0
N B:CYS185 4.3 9.7 1.0
O B:HOH2150 4.3 30.9 1.0
CA B:SER129 4.3 9.1 1.0
CB B:ASP181 4.3 11.7 1.0
C B:ILE179 4.4 9.5 1.0
CB B:CYS185 4.4 9.5 1.0
CA B:ASP181 4.4 10.2 1.0
CA B:PRO184 4.4 9.1 1.0
N B:PRO184 4.5 10.1 1.0
N B:THR131 4.5 9.0 1.0
N B:SER129 4.6 9.2 1.0
CA B:ILE179 4.6 10.0 1.0
CA B:LEU130 4.6 7.7 1.0
CA B:ASN183 4.7 8.5 1.0
C B:PRO184 4.7 9.8 1.0
CB B:THR131 4.7 8.8 1.0
CA B:THR131 4.8 7.7 1.0
N B:ILE179 4.8 9.3 1.0
O B:SER129 4.8 9.0 1.0
N B:LYS182 4.9 8.8 1.0
CA B:GLY128 5.0 10.7 1.0
OD2 B:ASP181 5.0 13.9 1.0
CA B:CYS185 5.0 10.3 1.0

Reference:

M.Machius, R.M.Wynn, J.L.Chuang, J.Li, R.Kluger, D.Yu, D.R.Tomchick, C.A.Brautigam, D.T.Chuang. A Versatile Conformational Switch Regulates Reactivity in Human Branched-Chain Alpha-Ketoacid Dehydrogenase. Structure V. 14 287 2006.
ISSN: ISSN 0969-2126
PubMed: 16472748
DOI: 10.1016/J.STR.2005.10.009
Page generated: Sun Dec 13 23:04:40 2020

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