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Potassium in PDB 1olx: Roles of HIS291-Alpha and HIS146-Beta' in the Reductive Acylation Reaction Catalyzed By Human Branched-Chain Alpha-Ketoacid Dehydrogenase

Enzymatic activity of Roles of HIS291-Alpha and HIS146-Beta' in the Reductive Acylation Reaction Catalyzed By Human Branched-Chain Alpha-Ketoacid Dehydrogenase

All present enzymatic activity of Roles of HIS291-Alpha and HIS146-Beta' in the Reductive Acylation Reaction Catalyzed By Human Branched-Chain Alpha-Ketoacid Dehydrogenase:
1.2.4.4;

Protein crystallography data

The structure of Roles of HIS291-Alpha and HIS146-Beta' in the Reductive Acylation Reaction Catalyzed By Human Branched-Chain Alpha-Ketoacid Dehydrogenase, PDB code: 1olx was solved by R.M.Wynn, M.Machius, J.L.Chuang, J.Li, D.R.Tomchick, D.T.Chuang, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 32.18 / 2.25
Space group P 31 2 1
Cell size a, b, c (Å), α, β, γ (°) 145.216, 145.216, 69.521, 90.00, 90.00, 120.00
R / Rfree (%) 16.1 / 21.4

Other elements in 1olx:

The structure of Roles of HIS291-Alpha and HIS146-Beta' in the Reductive Acylation Reaction Catalyzed By Human Branched-Chain Alpha-Ketoacid Dehydrogenase also contains other interesting chemical elements:

Manganese (Mn) 1 atom

Potassium Binding Sites:

The binding sites of Potassium atom in the Roles of HIS291-Alpha and HIS146-Beta' in the Reductive Acylation Reaction Catalyzed By Human Branched-Chain Alpha-Ketoacid Dehydrogenase (pdb code 1olx). This binding sites where shown within 5.0 Angstroms radius around Potassium atom.
In total 2 binding sites of Potassium where determined in the Roles of HIS291-Alpha and HIS146-Beta' in the Reductive Acylation Reaction Catalyzed By Human Branched-Chain Alpha-Ketoacid Dehydrogenase, PDB code: 1olx:
Jump to Potassium binding site number: 1; 2;

Potassium binding site 1 out of 2 in 1olx

Go back to Potassium Binding Sites List in 1olx
Potassium binding site 1 out of 2 in the Roles of HIS291-Alpha and HIS146-Beta' in the Reductive Acylation Reaction Catalyzed By Human Branched-Chain Alpha-Ketoacid Dehydrogenase


Mono view


Stereo pair view

A full contact list of Potassium with other atoms in the K binding site number 1 of Roles of HIS291-Alpha and HIS146-Beta' in the Reductive Acylation Reaction Catalyzed By Human Branched-Chain Alpha-Ketoacid Dehydrogenase within 5.0Å range:
probe atom residue distance (Å) B Occ
A:K501

b:28.6
occ:1.00
 O A:PRO163 2.7 7.9 1.0
O A:HOH2062 2.9 8.7 1.0
O A:SER161 3.0 11.5 1.0
OE1 A:GLN167 3.0 5.8 1.0
OG A:SER161 3.1 9.6 1.0
OG1 A:THR166 3.2 7.7 1.0
O A:HOH2064 3.3 29.6 1.0
C A:PRO163 3.8 12.0 1.0
C A:SER161 3.8 11.5 1.0
CD A:GLN167 4.0 8.8 1.0
O B:HOH2066 4.0 13.1 1.0
N A:GLN167 4.2 10.3 1.0
N A:SER161 4.2 12.4 1.0
N A:THR166 4.2 9.0 1.0
CB A:SER161 4.2 11.8 1.0
CA A:SER161 4.3 11.2 1.0
N A:PRO163 4.4 11.1 1.0
CB A:GLN167 4.4 10.0 1.0
O A:HOH2102 4.4 11.5 1.0
CB A:THR166 4.5 11.6 1.0
N A:ALA165 4.5 9.7 1.0
C A:SER162 4.6 11.9 1.0
CA A:PRO163 4.6 11.0 1.0
O A:HOH2065 4.6 14.4 1.0
O A:GLY111 4.6 13.7 1.0
N A:LEU164 4.7 11.6 1.0
CA A:LEU164 4.7 12.3 1.0
OE2 B:GLU113 4.7 15.3 1.0
NE2 A:GLN167 4.7 8.0 1.0
N A:SER162 4.7 10.3 1.0
CA A:THR166 4.8 10.5 1.0
C A:LEU164 4.8 12.0 1.0
CG A:GLN167 4.8 8.3 1.0
CD A:PRO163 4.8 10.9 1.0
O A:SER162 4.9 11.8 1.0
C A:THR166 4.9 10.6 1.0
CA A:GLN167 5.0 10.4 1.0

Potassium binding site 2 out of 2 in 1olx

Go back to Potassium Binding Sites List in 1olx
Potassium binding site 2 out of 2 in the Roles of HIS291-Alpha and HIS146-Beta' in the Reductive Acylation Reaction Catalyzed By Human Branched-Chain Alpha-Ketoacid Dehydrogenase


Mono view


Stereo pair view

A full contact list of Potassium with other atoms in the K binding site number 2 of Roles of HIS291-Alpha and HIS146-Beta' in the Reductive Acylation Reaction Catalyzed By Human Branched-Chain Alpha-Ketoacid Dehydrogenase within 5.0Å range:
probe atom residue distance (Å) B Occ
B:K502

b:28.1
occ:1.00
 O B:GLY128 2.9 12.4 1.0
O B:CYS178 2.9 8.4 1.0
O B:ASN183 2.9 15.7 1.0
O B:LEU130 3.0 5.7 1.0
O B:HOH2078 3.0 11.2 1.0
O B:ASP181 3.2 17.6 1.0
OG1 B:THR131 3.3 13.9 1.0
C B:LEU130 3.7 10.6 1.0
N B:LEU130 3.9 11.8 1.0
C B:ASN183 3.9 15.6 1.0
C B:CYS178 4.0 10.9 1.0
C B:GLY128 4.0 11.0 1.0
C B:ASP181 4.1 19.6 1.0
SG B:CYS185 4.1 16.6 1.0
N B:CYS185 4.1 12.6 1.0
O B:ILE179 4.1 15.8 1.0
C B:SER129 4.2 11.4 1.0
CB B:CYS185 4.3 15.4 1.0
CA B:SER129 4.3 10.8 1.0
N B:ASN183 4.3 13.0 1.0
C B:ILE179 4.4 16.9 1.0
CB B:ASP181 4.4 22.9 1.0
CA B:LEU130 4.4 11.1 1.0
CA B:PRO184 4.4 13.4 1.0
N B:ASP181 4.4 20.8 1.0
N B:THR131 4.4 9.6 1.0
CA B:ILE179 4.5 13.8 1.0
CA B:ASP181 4.6 20.7 1.0
CB B:THR131 4.6 13.1 1.0
C B:PRO184 4.6 13.7 1.0
N B:PRO184 4.6 14.1 1.0
N B:SER129 4.7 10.4 1.0
CA B:THR131 4.7 10.6 1.0
N B:ILE179 4.7 11.6 1.0
CA B:ASN183 4.8 14.1 1.0
O B:SER129 4.8 11.5 1.0
CA B:CYS185 4.9 12.7 1.0
CA B:CYS178 5.0 11.7 1.0

Reference:

R.M.Wynn, M.Machius, J.L.Chuang, J.Li, D.R.Tomchick, D.T.Chuang. Roles of HIS291-Alpha and HIS146-Beta' in the Reductive Acylation Reaction Catalyzed By Human Branched-Chain Alpha-Ketoacid Dehydrogenase: Refined Phosphorylation Loop Structure in the Active Site. J.Biol.Chem. V. 278 43402 2003.
ISSN: ISSN 0021-9258
PubMed: 12902323
DOI: 10.1074/JBC.M306204200
Page generated: Mon Aug 12 05:07:44 2024

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