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Potassium in PDB 1ols: Roles of HIS291-Alpha and HIS146-Beta' in the Reductive Acylation Reaction Catalyzed By Human Branched-Chain Alpha-Ketoacid Dehydrogenase

Enzymatic activity of Roles of HIS291-Alpha and HIS146-Beta' in the Reductive Acylation Reaction Catalyzed By Human Branched-Chain Alpha-Ketoacid Dehydrogenase

All present enzymatic activity of Roles of HIS291-Alpha and HIS146-Beta' in the Reductive Acylation Reaction Catalyzed By Human Branched-Chain Alpha-Ketoacid Dehydrogenase:
1.2.4.4;

Protein crystallography data

The structure of Roles of HIS291-Alpha and HIS146-Beta' in the Reductive Acylation Reaction Catalyzed By Human Branched-Chain Alpha-Ketoacid Dehydrogenase, PDB code: 1ols was solved by R.M.Wynn, M.Machius, J.L.Chuang, J.Li, D.R.Tomchick, D.T.Chuang, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 28.75 / 1.85
Space group P 31 2 1
Cell size a, b, c (Å), α, β, γ (°) 144.721, 144.721, 69.151, 90.00, 90.00, 120.00
R / Rfree (%) 17.2 / 19.9

Other elements in 1ols:

The structure of Roles of HIS291-Alpha and HIS146-Beta' in the Reductive Acylation Reaction Catalyzed By Human Branched-Chain Alpha-Ketoacid Dehydrogenase also contains other interesting chemical elements:

Manganese (Mn) 1 atom

Potassium Binding Sites:

The binding sites of Potassium atom in the Roles of HIS291-Alpha and HIS146-Beta' in the Reductive Acylation Reaction Catalyzed By Human Branched-Chain Alpha-Ketoacid Dehydrogenase (pdb code 1ols). This binding sites where shown within 5.0 Angstroms radius around Potassium atom.
In total 2 binding sites of Potassium where determined in the Roles of HIS291-Alpha and HIS146-Beta' in the Reductive Acylation Reaction Catalyzed By Human Branched-Chain Alpha-Ketoacid Dehydrogenase, PDB code: 1ols:
Jump to Potassium binding site number: 1; 2;

Potassium binding site 1 out of 2 in 1ols

Go back to Potassium Binding Sites List in 1ols
Potassium binding site 1 out of 2 in the Roles of HIS291-Alpha and HIS146-Beta' in the Reductive Acylation Reaction Catalyzed By Human Branched-Chain Alpha-Ketoacid Dehydrogenase


Mono view


Stereo pair view

A full contact list of Potassium with other atoms in the K binding site number 1 of Roles of HIS291-Alpha and HIS146-Beta' in the Reductive Acylation Reaction Catalyzed By Human Branched-Chain Alpha-Ketoacid Dehydrogenase within 5.0Å range:
probe atom residue distance (Å) B Occ
A:K501

b:26.5
occ:1.00
 O A:HOH2078 2.7 16.4 1.0
O A:PRO163 2.8 16.4 1.0
OG A:SER161 2.9 18.3 1.0
O A:SER161 2.9 19.2 1.0
OE1 A:GLN167 2.9 17.3 1.0
OE1 A:GLN112 3.0 26.4 1.0
OG1 A:THR166 3.1 18.1 1.0
C A:SER161 3.7 18.9 1.0
CD A:GLN112 3.8 27.6 1.0
C A:PRO163 3.8 19.6 1.0
CD A:GLN167 3.9 18.9 1.0
O A:HOH2130 4.0 16.4 1.0
N A:SER161 4.1 18.8 1.0
CB A:SER161 4.1 18.9 1.0
N A:GLN167 4.2 17.2 1.0
CA A:SER161 4.2 18.1 1.0
N A:THR166 4.2 14.8 1.0
CB A:THR166 4.4 17.9 1.0
CB A:GLN167 4.4 16.8 1.0
N A:PRO163 4.4 18.1 1.0
N A:ALA165 4.4 16.6 1.0
NE2 A:GLN112 4.5 32.7 1.0
CG A:GLN112 4.5 29.6 1.0
C A:SER162 4.6 19.1 1.0
CA A:LEU164 4.6 17.7 1.0
O A:HOH2129 4.6 18.8 1.0
O A:GLY111 4.6 20.8 1.0
N A:LEU164 4.6 17.8 1.0
CA A:PRO163 4.6 17.5 1.0
CG A:GLN167 4.7 15.7 1.0
C A:LEU164 4.7 17.5 1.0
O A:HOH2079 4.7 23.6 1.0
CA A:THR166 4.7 17.1 1.0
N A:SER162 4.7 18.0 1.0
NE2 A:GLN167 4.7 15.6 1.0
OE2 B:GLU113 4.8 18.6 1.0
CD A:PRO163 4.8 15.8 1.0
O A:SER162 4.9 19.3 1.0
C A:THR166 4.9 16.9 1.0
CA A:GLN167 4.9 17.2 1.0
CB A:GLN112 4.9 29.2 1.0

Potassium binding site 2 out of 2 in 1ols

Go back to Potassium Binding Sites List in 1ols
Potassium binding site 2 out of 2 in the Roles of HIS291-Alpha and HIS146-Beta' in the Reductive Acylation Reaction Catalyzed By Human Branched-Chain Alpha-Ketoacid Dehydrogenase


Mono view


Stereo pair view

A full contact list of Potassium with other atoms in the K binding site number 2 of Roles of HIS291-Alpha and HIS146-Beta' in the Reductive Acylation Reaction Catalyzed By Human Branched-Chain Alpha-Ketoacid Dehydrogenase within 5.0Å range:
probe atom residue distance (Å) B Occ
B:K502

b:32.9
occ:1.00
 O B:GLY128 2.8 20.1 1.0
O B:ASN183 2.8 21.4 1.0
O B:CYS178 2.9 21.2 1.0
O B:ASP181 2.9 22.4 1.0
O B:HOH2117 2.9 23.4 1.0
O B:LEU130 3.0 18.4 1.0
OG1 B:THR131 3.5 20.7 1.0
C B:LEU130 3.8 18.6 1.0
C B:ASN183 3.8 20.1 1.0
C B:ASP181 3.9 23.4 1.0
C B:GLY128 4.0 19.6 1.0
N B:LEU130 4.0 19.5 1.0
O B:ILE179 4.0 21.4 1.0
C B:CYS178 4.0 21.6 1.0
SG B:CYS185 4.1 23.2 1.0
O B:HOH2123 4.1 42.6 1.0
C B:SER129 4.1 20.0 1.0
N B:CYS185 4.2 17.9 1.0
N B:ASN183 4.2 20.9 1.0
CA B:SER129 4.3 19.0 1.0
C B:ILE179 4.3 22.2 1.0
CB B:CYS185 4.4 19.4 1.0
CB B:ASP181 4.4 24.7 1.0
N B:ASP181 4.4 23.8 1.0
CA B:PRO184 4.5 18.2 1.0
CA B:ASP181 4.5 23.1 1.0
CA B:LEU130 4.5 17.7 1.0
N B:THR131 4.5 17.5 1.0
CA B:ILE179 4.6 20.9 1.0
N B:SER129 4.6 19.5 1.0
N B:PRO184 4.6 19.7 1.0
C B:PRO184 4.6 17.4 1.0
CB B:THR131 4.7 18.8 1.0
O B:SER129 4.7 19.9 1.0
CA B:THR131 4.7 18.7 1.0
CA B:ASN183 4.7 19.8 1.0
N B:ILE179 4.8 20.8 1.0
N B:LYS182 4.9 21.5 1.0
CA B:CYS185 4.9 18.5 1.0

Reference:

R.M.Wynn, M.Machius, J.L.Chuang, J.Li, D.R.Tomchick, D.T.Chuang. Roles of HIS291-Alpha and HIS146-Beta' in the Reductive Acylation Reaction Catalyzed By Human Branched-Chain Alpha-Ketoacid Dehydrogenase: Refined Phosphorylation Loop Structure in the Active Site. J.Biol.Chem. V. 278 43402 2003.
ISSN: ISSN 0021-9258
PubMed: 12902323
DOI: 10.1074/JBC.M306204200
Page generated: Mon Aug 12 05:07:42 2024

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