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Potassium in PDB 1nf7: Ternary Complex of the Human Type II Inosine Monophosphate Dedhydrogenase with Ribavirin Monophosphate and C2- Mycophenolic Adenine Dinucleotide

Enzymatic activity of Ternary Complex of the Human Type II Inosine Monophosphate Dedhydrogenase with Ribavirin Monophosphate and C2- Mycophenolic Adenine Dinucleotide

All present enzymatic activity of Ternary Complex of the Human Type II Inosine Monophosphate Dedhydrogenase with Ribavirin Monophosphate and C2- Mycophenolic Adenine Dinucleotide:
1.1.1.205;

Protein crystallography data

The structure of Ternary Complex of the Human Type II Inosine Monophosphate Dedhydrogenase with Ribavirin Monophosphate and C2- Mycophenolic Adenine Dinucleotide, PDB code: 1nf7 was solved by D.Risal, M.D.Strickler, B.M.Goldstein, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 41.24 / 2.65
Space group I 4
Cell size a, b, c (Å), α, β, γ (°) 146.580, 146.580, 128.920, 90.00, 90.00, 90.00
R / Rfree (%) 23.8 / 27.7

Potassium Binding Sites:

The binding sites of Potassium atom in the Ternary Complex of the Human Type II Inosine Monophosphate Dedhydrogenase with Ribavirin Monophosphate and C2- Mycophenolic Adenine Dinucleotide (pdb code 1nf7). This binding sites where shown within 5.0 Angstroms radius around Potassium atom.
In total 2 binding sites of Potassium where determined in the Ternary Complex of the Human Type II Inosine Monophosphate Dedhydrogenase with Ribavirin Monophosphate and C2- Mycophenolic Adenine Dinucleotide, PDB code: 1nf7:
Jump to Potassium binding site number: 1; 2;

Potassium binding site 1 out of 2 in 1nf7

Go back to Potassium Binding Sites List in 1nf7
Potassium binding site 1 out of 2 in the Ternary Complex of the Human Type II Inosine Monophosphate Dedhydrogenase with Ribavirin Monophosphate and C2- Mycophenolic Adenine Dinucleotide


Mono view


Stereo pair view

A full contact list of Potassium with other atoms in the K binding site number 1 of Ternary Complex of the Human Type II Inosine Monophosphate Dedhydrogenase with Ribavirin Monophosphate and C2- Mycophenolic Adenine Dinucleotide within 5.0Å range:
probe atom residue distance (Å) B Occ
A:K902

b:0.8
occ:1.00
O A:CYS331 2.7 75.3 1.0
O A:GLY328 2.9 74.8 1.0
O A:HOH944 3.2 86.2 1.0
O A:GLY326 3.3 77.2 1.0
C A:GLY326 3.7 77.3 1.0
C A:SER327 3.7 95.9 1.0
O A:SER327 3.9 96.1 1.0
C A:CYS331 3.9 75.3 1.0
C A:GLY328 4.0 74.5 1.0
CA A:SER327 4.0 95.8 1.0
N A:SER327 4.1 95.8 1.0
N A:GLY328 4.1 75.2 1.0
CB A:CYS331 4.5 46.7 1.0
CA A:GLY326 4.6 77.0 1.0
CA A:CYS331 4.6 75.1 1.0
CA A:GLY328 4.6 74.8 1.0
NE2 A:GLN334 4.7 43.9 1.0
N A:CYS331 4.8 75.0 1.0
N A:ILE332 4.8 86.5 1.0
CA A:ILE332 4.9 86.6 1.0
N A:SER329 5.0 28.0 1.0

Potassium binding site 2 out of 2 in 1nf7

Go back to Potassium Binding Sites List in 1nf7
Potassium binding site 2 out of 2 in the Ternary Complex of the Human Type II Inosine Monophosphate Dedhydrogenase with Ribavirin Monophosphate and C2- Mycophenolic Adenine Dinucleotide


Mono view


Stereo pair view

A full contact list of Potassium with other atoms in the K binding site number 2 of Ternary Complex of the Human Type II Inosine Monophosphate Dedhydrogenase with Ribavirin Monophosphate and C2- Mycophenolic Adenine Dinucleotide within 5.0Å range:
probe atom residue distance (Å) B Occ
B:K901

b:0.7
occ:1.00
O B:CYS331 2.8 84.8 1.0
O B:GLY328 3.0 49.0 1.0
O B:HOH947 3.1 71.0 1.0
O B:GLY326 3.2 64.1 1.0
C B:GLY326 3.7 64.2 1.0
C B:SER327 3.7 81.7 1.0
O B:SER327 3.8 81.9 1.0
C B:CYS331 3.9 84.6 1.0
CA B:SER327 3.9 81.8 1.0
N B:SER327 4.0 81.8 1.0
C B:GLY328 4.0 48.9 1.0
N B:GLY328 4.1 49.5 1.0
CB B:CYS331 4.5 36.3 1.0
CA B:GLY326 4.6 64.0 1.0
CA B:GLY328 4.7 49.1 1.0
CA B:CYS331 4.7 84.3 1.0
N B:ILE332 4.8 71.0 1.0
N B:CYS331 4.8 84.2 1.0
CA B:ILE332 4.9 70.8 1.0

Reference:

D.Risal, M.D.Strickler, B.M.Goldstein. Crystal Structure of Human Inosine Monophosphate Dehydrogenase Type II Complexed with the Mpa/Nad Analog C2-Mad To Be Published.
Page generated: Sun Dec 13 22:53:58 2020

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