Potassium in PDB 1mxc: S-Adenosylmethionine Synthetase with 8-Br-Adp

All present enzymatic activity of S-Adenosylmethionine Synthetase with 8-Br-Adp:
2.5.1.6;

The structure of S-Adenosylmethionine Synthetase with 8-Br-Adp, PDB code: 1mxc was solved by F.Takusagawa, S.Kamitori, G.D.Markham, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	10.00 / 3.00
Space group	P 62 2 2
Cell size a, b, c (Å), α, β, γ (°)	128.900, 128.900, 139.800, 90.00, 90.00, 120.00
R / Rfree (%)	18.7 / 25.9

The structure of S-Adenosylmethionine Synthetase with 8-Br-Adp also contains other interesting chemical elements:

Magnesium	(Mg)	2 atoms
Bromine	(Br)	1 atom

The binding sites of Potassium atom in the S-Adenosylmethionine Synthetase with 8-Br-Adp (pdb code 1mxc). This binding sites where shown within 5.0 Angstroms radius around Potassium atom.
In total 2 binding sites of Potassium where determined in the S-Adenosylmethionine Synthetase with 8-Br-Adp, PDB code: 1mxc:
Jump to Potassium binding site number: 1; 2;

Potassium binding site 1 out of 2 in the S-Adenosylmethionine Synthetase with 8-Br-Adp


Mono view


Stereo pair view

A full contact list of Potassium with other atoms in the K binding site number 1 of S-Adenosylmethionine Synthetase with 8-Br-Adp within 5.0Å range: probe atom residue distance (Å) B Occ A:K413 b:77.7 occ:1.00 O A:SER263 2.6 20.8 1.0 OE1 A:GLU42 2.7 15.7 1.0 CD A:GLU42 3.1 12.3 1.0 OE2 A:GLU42 3.1 26.2 1.0 HG1 A:THR242 3.3 17.6 0.0 OG1 A:THR242 3.7 9.0 1.0 C A:SER263 3.8 14.8 1.0 O A:CYS41 3.8 20.1 1.0 CG A:LYS265 3.9 5.0 1.0 CE A:LYS265 4.1 12.9 1.0 CG A:GLU42 4.1 10.7 1.0 C A:GLY264 4.2 16.0 1.0 CA A:GLY264 4.2 15.8 1.0 O A:GLY264 4.4 22.1 1.0 C A:CYS41 4.4 16.3 1.0 N A:GLY264 4.5 16.4 1.0 N A:LYS265 4.5 11.9 1.0 CD A:LYS265 4.6 6.7 1.0 H A:LYS265 4.6 17.6 0.0 H A:CYS41 4.6 17.6 0.0 CA A:GLU42 4.7 7.0 1.0 N A:GLU42 4.8 13.3 1.0 CB A:THR242 4.8 5.6 1.0 N A:CYS41 4.8 12.9 1.0 CB A:GLU42 4.9 4.0 1.0 CB A:ALA261 4.9 8.8 1.0 CA A:SER263 5.0 12.5 1.0

Potassium binding site 2 out of 2 in the S-Adenosylmethionine Synthetase with 8-Br-Adp


Mono view


Stereo pair view

A full contact list of Potassium with other atoms in the K binding site number 2 of S-Adenosylmethionine Synthetase with 8-Br-Adp within 5.0Å range: probe atom residue distance (Å) B Occ A:K414 b:70.6 occ:1.00 O A:GLY243 2.5 14.0 1.0 CG2 A:ILE246 3.4 23.0 1.0 C A:GLY243 3.7 8.4 1.0 CB A:ILE246 4.0 15.6 1.0 CD A:ARG244 4.1 9.7 1.0 CA A:ARG244 4.1 12.4 1.0 CD1 A:ILE246 4.2 8.4 1.0 N A:ARG244 4.4 11.4 1.0 O A:ARG244 4.4 18.2 1.0 CG1 A:ILE246 4.5 9.1 1.0 H A:ILE246 4.5 17.6 0.0 C A:ARG244 4.6 16.6 1.0 CG A:ARG244 4.8 4.0 1.0 O A:GLY259 4.8 31.4 1.0 CA A:GLY243 4.9 10.4 1.0 CB A:ARG244 5.0 5.1 1.0 HE A:ARG244 5.0 17.6 0.0

F.Takusagawa, S.Kamitori, G.D.Markham. Structure and Function of S-Adenosylmethionine Synthetase: Crystal Structures of S-Adenosylmethionine Synthetase with Adp, Bradp, and Ppi at 28 Angstroms Resolution. Biochemistry V. 35 2586 1996.
ISSN: ISSN 0006-2960
PubMed: 8611562
DOI: 10.1021/BI952604Z