Potassium in PDB 1m6h: Human Glutathione-Dependent Formaldehyde Dehydrogenase

All present enzymatic activity of Human Glutathione-Dependent Formaldehyde Dehydrogenase:
1.1.1.1;

The structure of Human Glutathione-Dependent Formaldehyde Dehydrogenase, PDB code: 1m6h was solved by P.C.Sanghani, H.Robinson, W.F.Bosron, T.D.Hurley, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	30.00 / 2.00
Space group	P 43 21 2
Cell size a, b, c (Å), α, β, γ (°)	78.620, 78.620, 309.659, 90.00, 90.00, 90.00
R / Rfree (%)	18.5 / 21.8

The structure of Human Glutathione-Dependent Formaldehyde Dehydrogenase also contains other interesting chemical elements:

Zinc

(Zn)

4 atoms

The binding sites of Potassium atom in the Human Glutathione-Dependent Formaldehyde Dehydrogenase (pdb code 1m6h). This binding sites where shown within 5.0 Angstroms radius around Potassium atom.
In total 2 binding sites of Potassium where determined in the Human Glutathione-Dependent Formaldehyde Dehydrogenase, PDB code: 1m6h:
Jump to Potassium binding site number: 1; 2;

Potassium binding site 1 out of 2 in the Human Glutathione-Dependent Formaldehyde Dehydrogenase


Mono view


Stereo pair view

A full contact list of Potassium with other atoms in the K binding site number 1 of Human Glutathione-Dependent Formaldehyde Dehydrogenase within 5.0Å range: probe atom residue distance (Å) B Occ A:K2001 b:18.1 occ:1.00 O A:LYS187 2.8 16.2 1.0 O A:HOH3169 2.8 31.9 1.0 OH A:TYR263 2.8 10.7 1.0 O A:ALA186 2.9 16.4 1.0 OE2 A:GLU189 2.9 16.8 1.0 O A:HOH3246 2.9 20.3 1.0 O A:HOH3090 3.0 32.1 1.0 O A:HOH3331 3.1 46.9 1.0 C A:LYS187 3.6 16.0 1.0 CD A:GLU189 3.6 17.4 1.0 CB A:LYS187 3.8 19.7 1.0 CZ A:TYR263 3.9 12.4 1.0 OE1 A:GLU189 3.9 14.8 1.0 O A:HOH3013 4.0 11.9 1.0 C A:ALA186 4.0 16.0 1.0 O A:HOH3400 4.2 44.5 1.0 CE2 A:TYR263 4.2 13.6 1.0 CA A:LYS187 4.2 17.5 1.0 NZ B:LYS106 4.3 12.1 1.0 N A:LEU188 4.3 16.0 1.0 O B:HOH3030 4.4 16.3 1.0 O A:HOH3005 4.4 31.1 1.0 CA A:LEU188 4.5 18.1 1.0 O A:HOH3116 4.6 21.5 1.0 N A:LYS187 4.6 16.3 1.0 CG A:GLU189 4.7 15.6 1.0

Potassium binding site 2 out of 2 in the Human Glutathione-Dependent Formaldehyde Dehydrogenase


Mono view


Stereo pair view

A full contact list of Potassium with other atoms in the K binding site number 2 of Human Glutathione-Dependent Formaldehyde Dehydrogenase within 5.0Å range: probe atom residue distance (Å) B Occ B:K2002 b:20.3 occ:1.00 O B:LYS187 2.8 18.7 1.0 OH B:TYR263 2.8 15.3 1.0 OE2 B:GLU189 2.9 18.4 1.0 O A:HOH3354 2.9 27.2 1.0 O B:ALA186 2.9 18.3 1.0 O B:HOH3315 2.9 33.3 1.0 O B:HOH3279 3.0 22.6 1.0 C B:LYS187 3.5 18.6 1.0 CD B:GLU189 3.7 19.3 1.0 CB B:LYS187 3.8 21.7 1.0 CZ B:TYR263 3.9 14.5 1.0 O B:HOH3041 4.0 17.1 1.0 C B:ALA186 4.1 18.3 1.0 OE1 B:GLU189 4.1 16.7 1.0 NZ A:LYS106 4.1 16.0 1.0 CA B:LYS187 4.2 18.9 1.0 CE2 B:TYR263 4.2 14.8 1.0 N B:LEU188 4.4 17.5 1.0 O A:HOH3020 4.4 15.2 1.0 O B:HOH3132 4.4 25.3 1.0 O A:HOH3239 4.4 42.2 1.0 CA B:LEU188 4.6 18.5 1.0 N B:LYS187 4.6 16.4 1.0 CG B:GLU189 4.8 18.9 1.0

P.C.Sanghani, H.Robinson, W.F.Bosron, T.D.Hurley. Human Glutathione-Dependent Formaldehyde Dehydrogenase. Structures of Apo, Binary, and Inhibitory Ternary Complexes. Biochemistry V. 41 10778 2002.
ISSN: ISSN 0006-2960
PubMed: 12196016
DOI: 10.1021/BI0257639