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Potassium in PDB 1lrt: Crystal Structure of Ternary Complex of Tritrichomonas Foetus Inosine- 5'-Monophosphate Dehydrogenase: Structural Characterization of Nad+ Site in Microbial Enzyme

Enzymatic activity of Crystal Structure of Ternary Complex of Tritrichomonas Foetus Inosine- 5'-Monophosphate Dehydrogenase: Structural Characterization of Nad+ Site in Microbial Enzyme

All present enzymatic activity of Crystal Structure of Ternary Complex of Tritrichomonas Foetus Inosine- 5'-Monophosphate Dehydrogenase: Structural Characterization of Nad+ Site in Microbial Enzyme:
1.1.1.205;

Protein crystallography data

The structure of Crystal Structure of Ternary Complex of Tritrichomonas Foetus Inosine- 5'-Monophosphate Dehydrogenase: Structural Characterization of Nad+ Site in Microbial Enzyme, PDB code: 1lrt was solved by L.Gan, G.A.Petsko, L.Hedstrom, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 29.86 / 2.20
Space group P 21 21 21
Cell size a, b, c (Å), α, β, γ (°) 96.144, 112.369, 161.997, 90.00, 90.00, 90.00
R / Rfree (%) 21.2 / 24.6

Potassium Binding Sites:

The binding sites of Potassium atom in the Crystal Structure of Ternary Complex of Tritrichomonas Foetus Inosine- 5'-Monophosphate Dehydrogenase: Structural Characterization of Nad+ Site in Microbial Enzyme (pdb code 1lrt). This binding sites where shown within 5.0 Angstroms radius around Potassium atom.
In total 4 binding sites of Potassium where determined in the Crystal Structure of Ternary Complex of Tritrichomonas Foetus Inosine- 5'-Monophosphate Dehydrogenase: Structural Characterization of Nad+ Site in Microbial Enzyme, PDB code: 1lrt:
Jump to Potassium binding site number: 1; 2; 3; 4;

Potassium binding site 1 out of 4 in 1lrt

Go back to Potassium Binding Sites List in 1lrt
Potassium binding site 1 out of 4 in the Crystal Structure of Ternary Complex of Tritrichomonas Foetus Inosine- 5'-Monophosphate Dehydrogenase: Structural Characterization of Nad+ Site in Microbial Enzyme


Mono view


Stereo pair view

A full contact list of Potassium with other atoms in the K binding site number 1 of Crystal Structure of Ternary Complex of Tritrichomonas Foetus Inosine- 5'-Monophosphate Dehydrogenase: Structural Characterization of Nad+ Site in Microbial Enzyme within 5.0Å range:
probe atom residue distance (Å) B Occ
A:K1

b:33.6
occ:1.00
 O A:GLY20 2.3 23.8 1.0
OD2 D:ASP264 2.5 25.5 1.0
OG A:SER22 2.5 30.8 1.0
O D:PHE266 2.6 30.1 1.0
O A:ASN460 2.7 26.0 1.0
OD1 D:ASP264 2.9 27.0 1.0
CG D:ASP264 3.0 26.0 1.0
C A:GLY20 3.5 25.0 1.0
CB A:SER22 3.5 27.8 1.0
CB D:PHE266 3.6 25.3 1.0
N A:SER22 3.6 27.1 1.0
C A:ASN460 3.6 24.8 1.0
C D:PHE266 3.6 28.5 1.0
CB A:PRO19 3.9 25.8 1.0
N A:GLY20 3.9 23.6 1.0
CA A:ASN460 3.9 25.1 1.0
CA D:PHE266 4.1 27.4 1.0
CA A:SER22 4.1 28.4 1.0
C A:LEU21 4.2 26.8 1.0
CG D:PHE266 4.4 25.6 1.0
N A:LEU21 4.4 25.7 1.0
CA A:LEU21 4.4 24.7 1.0
CA A:GLY20 4.4 23.3 1.0
C A:PRO19 4.4 23.9 1.0
N D:PHE266 4.5 25.2 1.0
CB D:ASP264 4.5 24.3 1.0
O A:CYS459 4.5 28.6 1.0
CA A:PRO19 4.5 26.0 1.0
O D:HOH941 4.6 48.5 1.0
CB A:ASN460 4.7 25.3 1.0
N D:SER267 4.7 29.9 1.0
N A:CYS461 4.8 24.1 1.0
ND2 A:ASN460 4.9 25.3 1.0
O D:HOH923 4.9 19.1 1.0
O D:ASP264 4.9 21.5 1.0
CD2 D:PHE266 4.9 24.7 1.0
O A:LEU21 4.9 26.8 1.0

Potassium binding site 2 out of 4 in 1lrt

Go back to Potassium Binding Sites List in 1lrt
Potassium binding site 2 out of 4 in the Crystal Structure of Ternary Complex of Tritrichomonas Foetus Inosine- 5'-Monophosphate Dehydrogenase: Structural Characterization of Nad+ Site in Microbial Enzyme


Mono view


Stereo pair view

A full contact list of Potassium with other atoms in the K binding site number 2 of Crystal Structure of Ternary Complex of Tritrichomonas Foetus Inosine- 5'-Monophosphate Dehydrogenase: Structural Characterization of Nad+ Site in Microbial Enzyme within 5.0Å range:
probe atom residue distance (Å) B Occ
B:K1

b:39.4
occ:1.00
 O B:GLY20 2.3 23.3 1.0
OD2 A:ASP264 2.5 21.5 1.0
OG B:SER22 2.6 26.7 1.0
O A:PHE266 2.6 21.4 1.0
O B:ASN460 2.7 24.7 1.0
OD1 A:ASP264 2.9 18.5 1.0
CG A:ASP264 3.0 21.7 1.0
O3 A:TRS600 3.2 55.8 1.0
CB B:SER22 3.5 25.2 1.0
N B:SER22 3.5 24.1 1.0
C B:GLY20 3.6 23.5 1.0
C B:ASN460 3.6 24.8 1.0
C A:PHE266 3.6 21.4 1.0
CB A:PHE266 3.7 22.4 1.0
C3 A:TRS600 3.8 53.9 1.0
CA B:ASN460 3.8 25.3 1.0
CB B:PRO19 3.9 25.0 1.0
N B:GLY20 4.0 22.3 1.0
CA B:SER22 4.0 25.4 1.0
C B:LEU21 4.1 24.9 1.0
CA A:PHE266 4.2 21.5 1.0
CA B:LEU21 4.3 24.2 1.0
N B:LEU21 4.4 22.9 1.0
O B:CYS459 4.4 26.0 1.0
CA B:GLY20 4.5 22.7 1.0
N A:PHE266 4.5 20.7 1.0
CG A:PHE266 4.5 22.0 1.0
C B:PRO19 4.5 23.2 1.0
CB A:ASP264 4.5 20.9 1.0
CA B:PRO19 4.6 24.5 1.0
CB B:ASN460 4.6 25.8 1.0
N A:SER267 4.7 22.1 1.0
ND2 B:ASN460 4.8 25.8 1.0
N B:CYS461 4.8 25.1 1.0
O A:HOH943 4.9 20.6 1.0
O B:LEU21 4.9 26.5 1.0

Potassium binding site 3 out of 4 in 1lrt

Go back to Potassium Binding Sites List in 1lrt
Potassium binding site 3 out of 4 in the Crystal Structure of Ternary Complex of Tritrichomonas Foetus Inosine- 5'-Monophosphate Dehydrogenase: Structural Characterization of Nad+ Site in Microbial Enzyme


Mono view


Stereo pair view

A full contact list of Potassium with other atoms in the K binding site number 3 of Crystal Structure of Ternary Complex of Tritrichomonas Foetus Inosine- 5'-Monophosphate Dehydrogenase: Structural Characterization of Nad+ Site in Microbial Enzyme within 5.0Å range:
probe atom residue distance (Å) B Occ
C:K1

b:39.4
occ:1.00
 OD2 B:ASP264 2.3 24.7 1.0
O C:GLY20 2.4 23.5 1.0
OG C:SER22 2.5 25.1 1.0
O C:ASN460 2.6 26.0 1.0
OD1 B:ASP264 2.8 23.3 1.0
O B:PHE266 2.8 29.2 1.0
CG B:ASP264 2.9 25.9 1.0
CB C:SER22 3.5 26.2 1.0
C C:ASN460 3.5 25.2 1.0
C C:GLY20 3.6 26.6 1.0
N C:SER22 3.6 26.7 1.0
C B:PHE266 3.7 27.6 1.0
CB B:PHE266 3.8 23.1 1.0
CA C:ASN460 3.8 26.7 1.0
CB C:PRO19 3.9 27.0 1.0
N C:GLY20 3.9 25.5 1.0
CA C:SER22 4.2 27.7 1.0
CA B:PHE266 4.2 25.9 1.0
C C:LEU21 4.3 27.9 1.0
CB B:ASP264 4.4 25.0 1.0
O C:CYS459 4.4 26.7 1.0
N C:LEU21 4.4 28.5 1.0
CA C:GLY20 4.4 25.1 1.0
CA C:LEU21 4.5 27.6 1.0
C C:PRO19 4.5 25.7 1.0
CG B:PHE266 4.5 22.0 1.0
N B:PHE266 4.5 25.2 1.0
CA C:PRO19 4.5 25.6 1.0
CB C:ASN460 4.6 25.0 1.0
N C:CYS461 4.8 25.1 1.0
N B:SER267 4.8 28.9 1.0
CB B:SER267 4.8 31.9 1.0
ND2 C:ASN460 4.8 24.1 1.0
CD2 B:PHE266 4.9 20.8 1.0
O B:HOH917 4.9 22.1 1.0

Potassium binding site 4 out of 4 in 1lrt

Go back to Potassium Binding Sites List in 1lrt
Potassium binding site 4 out of 4 in the Crystal Structure of Ternary Complex of Tritrichomonas Foetus Inosine- 5'-Monophosphate Dehydrogenase: Structural Characterization of Nad+ Site in Microbial Enzyme


Mono view


Stereo pair view

A full contact list of Potassium with other atoms in the K binding site number 4 of Crystal Structure of Ternary Complex of Tritrichomonas Foetus Inosine- 5'-Monophosphate Dehydrogenase: Structural Characterization of Nad+ Site in Microbial Enzyme within 5.0Å range:
probe atom residue distance (Å) B Occ
D:K1

b:44.0
occ:1.00
 OD2 C:ASP264 2.4 24.8 1.0
O D:GLY20 2.5 20.5 1.0
OG D:SER22 2.6 27.9 1.0
O C:PHE266 2.7 25.4 1.0
O D:ASN460 2.7 24.0 1.0
OD1 C:ASP264 2.8 22.6 1.0
CG C:ASP264 2.9 24.4 1.0
CB D:SER22 3.5 25.7 1.0
C D:ASN460 3.6 24.1 1.0
C C:PHE266 3.7 24.7 1.0
N D:SER22 3.7 24.3 1.0
C D:GLY20 3.7 23.3 1.0
CB C:PHE266 3.7 22.9 1.0
CA D:ASN460 3.9 24.3 1.0
CB D:PRO19 3.9 24.9 1.0
N D:GLY20 4.0 24.0 1.0
CA D:SER22 4.2 26.2 1.0
CA C:PHE266 4.2 24.6 1.0
CB C:ASP264 4.4 22.1 1.0
C D:LEU21 4.4 24.4 1.0
O D:CYS459 4.4 27.1 1.0
N C:PHE266 4.5 22.1 1.0
CG C:PHE266 4.6 22.5 1.0
CA D:PRO19 4.6 25.3 1.0
CB D:ASN460 4.6 24.3 1.0
CA D:LEU21 4.6 23.2 1.0
CA D:GLY20 4.6 23.0 1.0
C D:PRO19 4.6 25.0 1.0
ND2 D:ASN460 4.6 22.1 1.0
N D:LEU21 4.6 23.6 1.0
O C:ASP264 4.7 22.2 1.0
N C:SER267 4.8 25.0 1.0
N D:CYS461 4.9 22.3 1.0
CB C:SER267 5.0 28.2 1.0
CG D:PRO19 5.0 24.5 1.0

Reference:

L.Gan, G.A.Petsko, L.Hedstrom. Crystal Structure of A Ternary Complex of Tritrichomonas Foetus Inosine 5'-Monophosphate Dehydrogenase: Nad+ Orients the Active Site Loop For Catalysis Biochemistry V. 41 13309 2003.
ISSN: ISSN 0006-2960
PubMed: 12403633
DOI: 10.1021/BI0203785
Page generated: Mon Aug 12 04:52:19 2024

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