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Potassium in PDB 1kee: Inactivation of the Amidotransferase Activity of Carbamoyl Phosphate Synthetase By the Antibiotic Acivicin

Enzymatic activity of Inactivation of the Amidotransferase Activity of Carbamoyl Phosphate Synthetase By the Antibiotic Acivicin

All present enzymatic activity of Inactivation of the Amidotransferase Activity of Carbamoyl Phosphate Synthetase By the Antibiotic Acivicin:
6.3.5.5;

Protein crystallography data

The structure of Inactivation of the Amidotransferase Activity of Carbamoyl Phosphate Synthetase By the Antibiotic Acivicin, PDB code: 1kee was solved by B.W.Miles, J.B.Thoden, H.M.Holden, F.M.Raushel, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 30.00 / 2.10
Space group P 21 21 21
Cell size a, b, c (Å), α, β, γ (°) 152.400, 164.400, 333.200, 90.00, 90.00, 90.00
R / Rfree (%) n/a / n/a

Other elements in 1kee:

The structure of Inactivation of the Amidotransferase Activity of Carbamoyl Phosphate Synthetase By the Antibiotic Acivicin also contains other interesting chemical elements:

Manganese (Mn) 12 atoms
Chlorine (Cl) 22 atoms

Potassium Binding Sites:

Pages:

>>> Page 1 <<< Page 2, Binding sites: 11 - 20; Page 3, Binding sites: 21 - 30; Page 4, Binding sites: 31 - 32;

Binding sites:

The binding sites of Potassium atom in the Inactivation of the Amidotransferase Activity of Carbamoyl Phosphate Synthetase By the Antibiotic Acivicin (pdb code 1kee). This binding sites where shown within 5.0 Angstroms radius around Potassium atom.
In total 32 binding sites of Potassium where determined in the Inactivation of the Amidotransferase Activity of Carbamoyl Phosphate Synthetase By the Antibiotic Acivicin, PDB code: 1kee:
Jump to Potassium binding site number: 1; 2; 3; 4; 5; 6; 7; 8; 9; 10;

Potassium binding site 1 out of 32 in 1kee

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Potassium binding site 1 out of 32 in the Inactivation of the Amidotransferase Activity of Carbamoyl Phosphate Synthetase By the Antibiotic Acivicin


Mono view


Stereo pair view

A full contact list of Potassium with other atoms in the K binding site number 1 of Inactivation of the Amidotransferase Activity of Carbamoyl Phosphate Synthetase By the Antibiotic Acivicin within 5.0Å range:
probe atom residue distance (Å) B Occ
A:K5004

b:24.3
occ:1.00
 O A:ILE242 2.6 23.7 1.0
OE2 A:GLU215 2.8 19.9 1.0
OG A:SER247 2.8 21.8 1.0
O A:ASP238 2.8 18.2 1.0
OD1 A:ASN236 2.9 23.5 1.0
O A:ALA239 2.9 22.8 1.0
C A:ALA239 3.6 27.7 1.0
C A:ASP238 3.6 25.4 1.0
CG A:ASN236 3.8 13.6 1.0
CB A:SER247 3.8 14.3 1.0
C A:ILE242 3.8 33.2 1.0
CD A:GLU215 3.8 31.7 1.0
CB A:ASN236 3.9 11.0 1.0
CB A:GLU215 4.0 16.5 1.0
N A:ALA239 4.2 20.0 1.0
O2' A:ADP2001 4.2 19.6 1.0
CA A:ALA239 4.3 24.9 1.0
CG A:GLU215 4.3 14.1 1.0
N A:MET240 4.3 16.9 1.0
CB A:ASP238 4.3 11.2 1.0
CB A:ILE242 4.4 21.1 1.0
C A:HIS243 4.4 27.5 1.0
N A:THR244 4.4 20.1 1.0
O A:HIS243 4.5 17.5 1.0
CA A:ILE242 4.5 19.1 1.0
N A:ILE242 4.5 22.9 1.0
CA A:ASP238 4.5 22.2 1.0
CA A:MET240 4.5 15.1 1.0
CA A:THR244 4.6 25.5 1.0
OE1 A:GLU215 4.7 28.5 1.0
CG2 A:ILE242 4.7 15.4 1.0
N A:HIS243 4.8 15.7 1.0
CG2 A:THR244 4.8 21.2 1.0
ND2 A:ASN236 5.0 19.1 1.0
CA A:HIS243 5.0 9.3 1.0

Potassium binding site 2 out of 32 in 1kee

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Potassium binding site 2 out of 32 in the Inactivation of the Amidotransferase Activity of Carbamoyl Phosphate Synthetase By the Antibiotic Acivicin


Mono view


Stereo pair view

A full contact list of Potassium with other atoms in the K binding site number 2 of Inactivation of the Amidotransferase Activity of Carbamoyl Phosphate Synthetase By the Antibiotic Acivicin within 5.0Å range:
probe atom residue distance (Å) B Occ
A:K5005

b:27.7
occ:1.00
 O A:MET300 2.6 23.4 1.0
OE1 A:GLU299 2.8 32.0 1.0
O A:HOH5128 2.9 30.8 1.0
OE1 A:GLU127 2.9 30.6 1.0
O A:HOH5129 3.0 24.9 1.0
O A:ALA126 3.3 33.3 1.0
OD1 A:ASN301 3.5 26.9 1.0
C A:MET300 3.7 26.9 1.0
CD A:GLU127 3.7 15.2 1.0
MN A:MN2002 3.8 31.8 1.0
CD A:GLU299 3.8 25.5 1.0
C A:ALA126 4.0 23.9 1.0
NH1 A:ARG129 4.1 21.2 1.0
N A:MET300 4.2 23.4 1.0
OE2 A:GLU127 4.3 37.2 1.0
CG A:ASN301 4.3 21.9 1.0
CB A:GLU299 4.3 15.2 1.0
CZ A:ARG129 4.4 0.0 1.0
CA A:GLU127 4.5 13.3 1.0
N A:ASN301 4.5 21.9 1.0
CA A:ASN301 4.5 33.7 1.0
NH2 A:ARG129 4.5 17.8 1.0
N A:GLU127 4.6 23.0 1.0
CA A:MET300 4.6 29.3 1.0
CG A:GLU299 4.6 18.9 1.0
OE2 A:GLU299 4.7 22.9 1.0
O A:HOH5096 4.7 26.8 1.0
CB A:ALA126 4.7 22.0 1.0
CG A:GLU127 4.8 17.4 1.0
CD A:PRO302 4.8 18.2 1.0
O A:HOH5130 4.9 27.8 1.0
O3B A:ADP2001 4.9 25.7 1.0
CA A:ALA126 4.9 23.1 1.0
CB A:ASN301 4.9 21.1 1.0

Potassium binding site 3 out of 32 in 1kee

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Potassium binding site 3 out of 32 in the Inactivation of the Amidotransferase Activity of Carbamoyl Phosphate Synthetase By the Antibiotic Acivicin


Mono view


Stereo pair view

A full contact list of Potassium with other atoms in the K binding site number 3 of Inactivation of the Amidotransferase Activity of Carbamoyl Phosphate Synthetase By the Antibiotic Acivicin within 5.0Å range:
probe atom residue distance (Å) B Occ
A:K5009

b:38.7
occ:1.00
 O2B A:ADP2007 2.3 35.7 1.0
OD1 A:ASN843 2.5 91.4 1.0
OE2 A:GLU841 2.7 24.7 1.0
OE1 A:GLU841 3.0 56.3 1.0
CD A:GLU841 3.2 27.3 1.0
O3B A:ADP2007 3.3 26.1 1.0
PB A:ADP2007 3.4 27.0 1.0
O A:HOH5666 3.4 45.6 1.0
O A:HOH5504 3.5 61.2 1.0
CG A:ASN843 3.5 34.3 1.0
O A:HOH5501 3.7 32.8 1.0
NH2 A:ARG845 3.9 0.0 1.0
ND2 A:ASN843 3.9 40.9 1.0
MN A:MN5008 4.0 28.5 1.0
O A:HOH5441 4.0 23.8 1.0
O A:HOH5442 4.0 37.5 1.0
O A:HOH5467 4.1 17.1 1.0
O1B A:ADP2007 4.4 31.2 1.0
O A:HOH5768 4.4 41.4 1.0
O3A A:ADP2007 4.5 28.8 1.0
OE1 A:GLU673 4.6 0.0 1.0
CG A:GLU841 4.7 24.8 1.0
O2A A:ADP2007 4.8 24.7 1.0
CB A:ASN843 4.8 28.5 1.0

Potassium binding site 4 out of 32 in 1kee

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Potassium binding site 4 out of 32 in the Inactivation of the Amidotransferase Activity of Carbamoyl Phosphate Synthetase By the Antibiotic Acivicin


Mono view


Stereo pair view

A full contact list of Potassium with other atoms in the K binding site number 4 of Inactivation of the Amidotransferase Activity of Carbamoyl Phosphate Synthetase By the Antibiotic Acivicin within 5.0Å range:
probe atom residue distance (Å) B Occ
A:K5010

b:24.4
occ:1.00
 OE2 A:GLU761 2.6 27.2 1.0
O A:VAL787 2.6 19.6 1.0
ND1 A:HIS781 2.7 31.4 1.0
O A:GLU783 2.8 26.5 1.0
O A:GLN784 2.8 24.7 1.0
OG A:SER792 2.9 29.1 1.0
C A:GLN784 3.5 37.2 1.0
CB A:GLU761 3.5 18.7 1.0
CD A:GLU761 3.6 26.8 1.0
CE1 A:HIS781 3.6 19.5 1.0
C A:GLU783 3.7 26.3 1.0
CG A:HIS781 3.7 22.4 1.0
C A:VAL787 3.8 24.0 1.0
CB A:SER792 3.8 13.5 1.0
CB A:HIS781 3.9 27.7 1.0
N A:ALA785 4.1 17.9 1.0
CG A:GLU761 4.1 27.6 1.0
CB A:VAL787 4.2 27.6 1.0
CA A:ALA785 4.2 18.7 1.0
O2' A:ADP2007 4.2 26.5 1.0
N A:VAL787 4.3 18.8 1.0
CA A:VAL787 4.4 20.3 1.0
CB A:GLU783 4.4 14.9 1.0
N A:GLN784 4.4 34.3 1.0
O A:HIS788 4.4 19.1 1.0
CA A:GLN784 4.4 21.4 1.0
OE1 A:GLU761 4.5 21.4 1.0
C A:HIS788 4.5 31.4 1.0
CG1 A:VAL787 4.6 15.5 1.0
N A:SER789 4.6 20.0 1.0
CA A:GLU783 4.6 24.3 1.0
CA A:SER789 4.6 17.2 1.0
O A:HOH5473 4.7 18.2 1.0
NE2 A:HIS781 4.8 18.0 1.0
N A:GLY786 4.8 21.9 1.0
C A:ALA785 4.9 23.7 1.0
CA A:GLU761 4.9 13.6 1.0
N A:HIS788 4.9 17.9 1.0
CD2 A:HIS781 4.9 17.6 1.0

Potassium binding site 5 out of 32 in 1kee

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Potassium binding site 5 out of 32 in the Inactivation of the Amidotransferase Activity of Carbamoyl Phosphate Synthetase By the Antibiotic Acivicin


Mono view


Stereo pair view

A full contact list of Potassium with other atoms in the K binding site number 5 of Inactivation of the Amidotransferase Activity of Carbamoyl Phosphate Synthetase By the Antibiotic Acivicin within 5.0Å range:
probe atom residue distance (Å) B Occ
A:K5013

b:59.2
occ:1.00
 O A:HOH5134 2.5 29.0 1.0
OG1 A:THR143 3.0 36.6 1.0
O A:THR143 3.1 31.6 1.0
O A:ALA144 3.1 29.6 1.0
O A:HOH5820 3.3 69.0 1.0
O A:HOH5140 3.4 38.4 1.0
O A:HOH5139 3.5 54.3 1.0
C A:ALA144 3.6 18.9 1.0
C A:THR143 3.7 38.5 1.0
O A:HOH5168 3.8 55.1 1.0
CA A:ARG145 3.8 25.9 1.0
N A:ARG145 3.8 29.5 1.0
CB A:THR143 4.2 27.6 1.0
CA A:THR143 4.4 29.6 1.0
N A:ALA144 4.4 31.7 1.0
N A:SER146 4.4 35.1 1.0
CA A:ALA144 4.5 24.3 1.0
N A:THR143 4.6 32.2 1.0
C A:ARG145 4.6 35.7 1.0
OD2 A:ASP133 4.6 99.2 1.0
OG A:SER146 4.8 45.5 1.0
OD1 A:ASP133 4.8 0.0 1.0
O A:HOH5141 4.8 32.0 1.0
O A:HOH5611 4.8 35.8 1.0
CB A:ARG145 4.9 27.6 1.0

Potassium binding site 6 out of 32 in 1kee

Go back to Potassium Binding Sites List in 1kee
Potassium binding site 6 out of 32 in the Inactivation of the Amidotransferase Activity of Carbamoyl Phosphate Synthetase By the Antibiotic Acivicin


Mono view


Stereo pair view

A full contact list of Potassium with other atoms in the K binding site number 6 of Inactivation of the Amidotransferase Activity of Carbamoyl Phosphate Synthetase By the Antibiotic Acivicin within 5.0Å range:
probe atom residue distance (Å) B Occ
A:K5014

b:52.8
occ:1.00
 N A:GLU383 2.9 17.3 1.0
OD1 A:ASN602 3.1 24.0 1.0
O A:GLU383 3.2 25.0 1.0
OE2 A:GLU604 3.2 30.7 1.0
N A:ASN570 3.2 22.6 1.0
OD1 A:ASN570 3.3 45.3 1.0
CD A:GLU604 3.4 44.7 1.0
ND2 A:ASN602 3.4 24.1 1.0
CG A:ASN602 3.5 30.2 1.0
CA A:GLY382 3.6 15.0 1.0
CG A:ASN570 3.7 49.3 1.0
C A:GLY382 3.7 24.1 1.0
CG A:GLU604 3.7 24.2 1.0
OE1 A:GLU604 3.9 25.1 1.0
CB A:ASN570 3.9 23.2 1.0
CA A:GLU383 3.9 21.8 1.0
C A:GLU383 3.9 19.4 1.0
CG A:GLU383 4.0 25.2 1.0
CA A:PRO569 4.0 17.4 1.0
CA A:ASN570 4.1 19.7 1.0
C A:PRO569 4.1 23.2 1.0
CB A:GLU604 4.2 22.4 1.0
O A:ASN570 4.5 21.1 1.0
CB A:PRO569 4.5 11.8 1.0
ND2 A:ASN570 4.5 31.7 1.0
CB A:GLU383 4.6 20.2 1.0
CB A:ASN602 4.7 13.3 1.0
C A:ASN570 4.8 20.0 1.0
O A:GLY382 4.9 20.4 1.0
CD A:PRO603 4.9 16.3 1.0
N A:GLY382 5.0 31.0 1.0

Potassium binding site 7 out of 32 in 1kee

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Potassium binding site 7 out of 32 in the Inactivation of the Amidotransferase Activity of Carbamoyl Phosphate Synthetase By the Antibiotic Acivicin


Mono view


Stereo pair view

A full contact list of Potassium with other atoms in the K binding site number 7 of Inactivation of the Amidotransferase Activity of Carbamoyl Phosphate Synthetase By the Antibiotic Acivicin within 5.0Å range:
probe atom residue distance (Å) B Occ
A:K5015

b:54.3
occ:1.00
 O A:GLY112 2.7 37.1 1.0
O A:HOH5026 2.8 47.9 1.0
O A:ASP84 3.0 41.9 1.0
OG1 A:THR114 3.0 53.2 1.0
C A:ASP84 3.8 41.4 1.0
C A:GLY112 3.8 62.9 1.0
O A:HOH5025 3.8 77.0 1.0
N A:THR114 3.9 33.4 1.0
CB A:THR114 3.9 35.6 1.0
CA A:ASP84 4.1 31.7 1.0
CB A:ASP84 4.3 76.7 1.0
OD2 A:ASP84 4.3 67.4 1.0
CA A:VAL113 4.5 39.1 1.0
C A:VAL113 4.5 27.8 1.0
N A:VAL113 4.6 61.5 1.0
CA A:THR114 4.6 52.4 1.0
O A:HOH5088 4.8 56.2 1.0
CA A:GLY112 4.8 61.8 1.0
CG A:ASP84 4.9 0.0 1.0
N A:ALA85 5.0 38.6 1.0
O A:ASP6 5.0 50.9 1.0

Potassium binding site 8 out of 32 in 1kee

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Potassium binding site 8 out of 32 in the Inactivation of the Amidotransferase Activity of Carbamoyl Phosphate Synthetase By the Antibiotic Acivicin


Mono view


Stereo pair view

A full contact list of Potassium with other atoms in the K binding site number 8 of Inactivation of the Amidotransferase Activity of Carbamoyl Phosphate Synthetase By the Antibiotic Acivicin within 5.0Å range:
probe atom residue distance (Å) B Occ
B:K5016

b:45.1
occ:1.00
 O B:HIS16 2.7 27.7 1.0
O B:ASP112 2.8 20.9 1.0
O B:HOH5068 2.9 46.4 1.0
O A:HOH5421 3.0 31.4 1.0
O A:HOH5422 3.3 26.8 1.0
C B:HIS16 3.9 24.8 1.0
C B:ASP112 4.0 29.3 1.0
O A:HOH5420 4.3 36.7 1.0
CA B:GLY17 4.4 18.8 1.0
NH2 A:ARG494 4.4 38.2 1.0
CL B:CL5021 4.5 33.8 1.0
CA B:ILE113 4.5 25.2 1.0
O B:HOH5069 4.6 26.3 1.0
N B:GLY17 4.6 36.5 1.0
N B:ILE113 4.7 29.3 1.0
CB B:ASP112 4.7 18.3 1.0
CZ A:ARG494 4.8 40.0 1.0
CG2 B:ILE113 4.8 24.2 1.0
NH1 A:ARG494 4.9 24.8 1.0
CA B:HIS16 5.0 23.9 1.0

Potassium binding site 9 out of 32 in 1kee

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Potassium binding site 9 out of 32 in the Inactivation of the Amidotransferase Activity of Carbamoyl Phosphate Synthetase By the Antibiotic Acivicin


Mono view


Stereo pair view

A full contact list of Potassium with other atoms in the K binding site number 9 of Inactivation of the Amidotransferase Activity of Carbamoyl Phosphate Synthetase By the Antibiotic Acivicin within 5.0Å range:
probe atom residue distance (Å) B Occ
C:K5026

b:18.5
occ:1.00
 OE2 C:GLU215 2.6 21.0 1.0
O C:ASP238 2.6 32.4 1.0
O C:ILE242 2.7 21.3 1.0
O C:ALA239 2.8 17.3 1.0
OG C:SER247 2.8 23.7 1.0
OD1 C:ASN236 2.9 37.6 1.0
C C:ALA239 3.5 23.5 1.0
C C:ASP238 3.6 25.5 1.0
CD C:GLU215 3.6 18.9 1.0
CG C:ASN236 3.7 18.4 1.0
CB C:ASN236 3.8 14.1 1.0
C C:ILE242 3.8 14.9 1.0
CB C:SER247 3.9 17.4 1.0
CB C:GLU215 4.0 8.6 1.0
CG C:GLU215 4.1 11.9 1.0
O2' C:ADP2023 4.2 18.1 1.0
N C:ALA239 4.3 15.6 1.0
CA C:ALA239 4.3 15.4 1.0
N C:MET240 4.3 22.8 1.0
C C:HIS243 4.3 19.5 1.0
CB C:ASP238 4.4 16.1 1.0
N C:THR244 4.4 24.1 1.0
O C:HIS243 4.4 24.5 1.0
N C:ILE242 4.4 20.4 1.0
CB C:ILE242 4.4 14.7 1.0
CA C:ILE242 4.5 18.2 1.0
CA C:THR244 4.5 15.4 1.0
CA C:ASP238 4.5 18.5 1.0
OE1 C:GLU215 4.5 22.1 1.0
CA C:MET240 4.6 28.6 1.0
N C:HIS243 4.8 22.4 1.0
ND2 C:ASN236 4.9 17.5 1.0
CG2 C:ILE242 5.0 12.4 1.0
CA C:HIS243 5.0 13.0 1.0

Potassium binding site 10 out of 32 in 1kee

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Potassium binding site 10 out of 32 in the Inactivation of the Amidotransferase Activity of Carbamoyl Phosphate Synthetase By the Antibiotic Acivicin


Mono view


Stereo pair view

A full contact list of Potassium with other atoms in the K binding site number 10 of Inactivation of the Amidotransferase Activity of Carbamoyl Phosphate Synthetase By the Antibiotic Acivicin within 5.0Å range:
probe atom residue distance (Å) B Occ
C:K5027

b:29.0
occ:1.00
 OE1 C:GLU299 2.6 22.7 1.0
O C:MET300 2.7 21.9 1.0
O C:HOH5150 2.8 28.9 1.0
OE1 C:GLU127 2.9 31.6 1.0
O C:HOH5618 3.0 41.5 1.0
O C:HOH5151 3.2 24.9 1.0
O C:ALA126 3.4 25.3 1.0
OD1 C:ASN301 3.5 27.8 1.0
CD C:GLU299 3.7 30.1 1.0
MN C:MN2024 3.7 28.3 1.0
C C:MET300 3.8 25.2 1.0
CD C:GLU127 3.8 61.8 1.0
C C:ALA126 4.1 21.3 1.0
N C:MET300 4.1 18.1 1.0
OE2 C:GLU127 4.2 33.8 1.0
CB C:GLU299 4.3 14.2 1.0
CG C:ASN301 4.3 18.0 1.0
NH1 C:ARG129 4.3 32.0 1.0
CA C:GLU127 4.4 18.5 1.0
CA C:ASN301 4.5 20.8 1.0
N C:ASN301 4.5 21.3 1.0
CG C:GLU299 4.5 8.0 1.0
N C:GLU127 4.5 30.1 1.0
CA C:MET300 4.6 15.8 1.0
OE2 C:GLU299 4.6 25.9 1.0
CZ C:ARG129 4.6 38.2 1.0
NH2 C:ARG129 4.6 26.4 1.0
O C:HOH5118 4.7 19.9 1.0
O3B C:ADP2023 4.7 26.1 1.0
CD C:PRO302 4.8 23.3 1.0
CG C:GLU127 4.9 23.3 1.0
CB C:ALA126 4.9 18.8 1.0
O C:HOH5152 4.9 30.0 1.0
CB C:ASN301 4.9 17.8 1.0

Reference:

B.W.Miles, J.B.Thoden, H.M.Holden, F.M.Raushel. Inactivation of the Amidotransferase Activity of Carbamoyl Phosphate Synthetase By the Antibiotic Acivicin. J.Biol.Chem. V. 277 4368 2002.
ISSN: ISSN 0021-9258
PubMed: 11729189
DOI: 10.1074/JBC.M108582200
Page generated: Mon Aug 12 04:46:41 2024

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